Protein Alignment Cc2d2a and CC2D2B

DIOPT Version :10

• Sequence 1: NP_611229.2
• Gene: Cc2d2a / 36982
• FlyBaseID: FBgn0263113
• Length: 1336
• Species: Drosophila melanogaster
• Sequence 2: NP_001335937.1
• Gene: CC2D2B / 387707
• HGNCID: 31666
• Length: 1437
• Species: Homo sapiens
• Alignment Length: 1551
• Identity: 341/1551 - (21%)
• Similarity: 615/1551 - (39%)
• Gaps: 369/1551 - (23%)

  Fly     1 MEAALSRKTAKKKRKTHTTRGYRKREQEVQKLIR----ATEGRISGPEHDMEAL----------S 51
            ::|..::..||      |.||..:.:.::.|:.:    :||..|....|....|          |
Human    34 LDAEENQNVAK------TLRGKVREKLKISKINKGEKSSTEQLIDSEIHQRSKLSPQTEVSLDES 92

  Fly    52 LQFF--HGFEG-------EMQQEN---------DFAVEDCQESDEDSGGELAEEPTDSPSQTFIH 98
            |.||  .|.||       |.:..|         ...:::..||:|:   |..:|        ||.
Human    93 LSFFILSGEEGSALGKSSEQRPVNRSYPKCFSLGVNLQNVAESEEE---EFMKE--------FIL 146

  Fly    99 IDLHDPPLA-----WGQLFKQRHYYDESLLYRPSNTLHFQLHLSDLSEL-KDSQIRML------- 150
            .|:.....|     ..|:.||:     :.::.||::     .:.:..:| ||...|:|
Human   147 TDILKVKAADYEDDQEQIKKQK-----ANIFVPSSS-----PVVNQRKLPKDMMPRILEDEGFYI 201

  Fly   151 NRYQEQSKSKSGKLGSDLI------------GQLSG----------------QKPASFLMGKHLY 187
            .|..|..|....|:.:.|:            |::..                ::|.:.|: |.:|
Human   202 QRKPEIYKKTCNKMENRLLKLEEGKCWFGESGEIMSLPTPIKQSWNFRLNVRKEPLNPLL-KTIY 265

  Fly   188 RSVCHRRFQSVFFPPMPPSELKGLPSRRCLKLCLKQLRFSLHPQLLEEHRLAQQLEDLFDVYSQQ 252
            |........|.|.     ::::|......|.|.:..|:||.|....:|..|..:|..|::.:..:
Human   266 RKAVKYDLGSSFM-----NKMEGSREIYQLDLNIVGLQFSHHHLFNQEQVLCARLLQLYECFQDR 325

  Fly   253 RKQRICRKLREELEIARQVALKLLASAGQDQTAEVKRQLKLTRQLRQRYY-----------AESA 306
            ::|.:.:.|.|:|: |...|.||     .::.:|:.   :|||:..|.||           .|..
Human   326 QQQNVSQLLYEKLK-ALTDATKL-----SNENSEIN---QLTRKSLQDYYWQISNTKQMYDLERG 381

  Fly   307 AQRNLLQRLLKEWAKLKELRRQQRFQCTRFQLGLRVVHPPDLEASYCAWKESFETDLAEVYREH- 370
            ...:||..:|:.|.::|.||..|.|..|..:|.::     .::.:.|..:|.. ::::|..:::
Human   382 KDLSLLHSILRTWKQIKSLRHGQGFTSTPIKLQVQ-----RIKMNKCDEQEQI-SEMSETEKKNE 440

  Fly   371 ---------LE-LFYTRLRLWTDQKSHSRTATGHSKP-PRKPQ--FDRIMASLRKEYDKTFKDPE 422
                     || |.|    |.:|:....|.     || ..:||  |...:.||.|
Human   441 GKELKNGKKLESLSY----LASDETEIERI-----KPITLRPQLSFTAELTSLSK---------- 486

  Fly   423 EPYVEVFRLHADEATARLSIPGGDQLPKARNYFLKIFLDGQFVGQSRTYRLEPDLQISINECIGV 487
                  ..||..:..|::         :...||:|||.:.:.|..:....|:.|.::...:...:
Human   487 ------CSLHEQKRRAKI---------QKLKYFIKIFYNNKQVSCTSVSPLQFDFKVMFQQIFNI 536

  Fly   488 LLERSLPENLNIWLYEKSTLTPKSRRLAQISTPL----VLSSKDDAVQ------EKLSFQALSST 542
            .| ...||.:.:.:||||   .::..||::..||    .|..| .|:|      :||...|  ..
Human   537 QL-MYWPEVICLEVYEKS---KRTSLLAKLYIPLPNYTELKGK-TALQYVEFSSDKLVMPA--DG 594

  Fly   543 QLAGDVYLYYEYRSTE----------GWGSALHLDD----VQRLPDALRQTLL-------PQSLP 586
            ::..:|....|...||          .:..:..||:    :..:|.:||.:..       .:|:|
Human   595 EVGSNVPFLLEGNGTEELCLLTSGKLSYSLSWSLDENGLPLIPMPQSLRSSYCSMLRNVDARSVP 659

  Fly   587 ALP----------QASKELVTPRPPS----------GRIKKSQLPSLIFAEQ---QLQFCGLDVL 628
            .:|          .|::..:.|..|.          .|:|...:|.....||   :..|...:.:
Human   660 GIPWLMNEQKLFEWANEVRIDPNNPEYSDLMESVTYMRLKGQDIPKYFRLEQLQDEFNFVSEEEM 724

  Fly   629 LDNRRFQLLHSRH---------QQRNLHTKQLRFVPAL---------EQEISEEEPLPDGRGTVQ 675
            ..::|||||..|:         ||..||..:   :|.|         |:|:|..:.
Human   725 AKSKRFQLLQLRNAGQLDNFLLQQMPLHDTE---IPDLVFQEYESQKEKEVSVSDV--------- 777

  Fly   676 LLEPGTYWNPIDLHKHRGRKFLQLLYEVIASQSARRAKALQTPLPLLLLAEDSDRSSGTGWTALW 740
                    |.|...:.....||:.:..:|..:..:.:|.     .|..:..|.:....|  :.|.
Human   778 --------NSITAQRINSANFLKKVRRLIMKRIVKISKC-----NLSDIVNDYEEIVST--SQLT 827

  Fly   741 RAFCSVFQGQRNSLP-REPSGWSGHQSAPDLFKSFCVSLHVVRATGVPVRSRHILNLNERRSSAG 804
            .|.|...:.:|...| |:.......|:..|  ....:.:.:|||..:|.|...|        :..
Human   828 DAVCKFVEPRRKLKPQRKERKKVTAQAISD--GDIKILVRIVRAYNIPTRKTTI--------NGS 882

  Fly   805 GDMST----------------SLFVTQTLMYSNVRPFVTLSYGQRLCRSRTAEGSNPTWNEQLQL 853
            .||.|                |:...:||....|.|||.:|:...:.::.||.||:|.|||::::
Human   883 LDMPTCLKSSISCLRHRETIKSVASDETLHEDTVHPFVEVSFQHTVYKTNTASGSHPCWNEEIKV 947

  Fly   854 QIQSQFGD--------LRDDLKISLFDELIEQQYSD---EASDVYQRVQCNWLGEFRVPINSLLA 907
            ...|...|        ::|::.|::|||::.:::.|   ::...:..::.||||....|.::||.
Human   948 DFVSPGHDYSFSSLSKIKDNIYINIFDEMMTEKHEDHCLKSCSGHSYIRKNWLGCIVFPFSALLQ 1012

  Fly   908 SRTFEGCIELAMPKVLVGYKRPLIDSVTNMPTDQYPE-------FKEAVHLWFYLSIEPGGGDLA 965
            .....|..::.:|.||:||        |...|..:|:       .||...|..:.:|||
Human  1013 QSEISGTFQVTIPPVLLGY--------TWSNTYVFPKEDSNEQNLKECTFLNIFATIEP------ 1063

  Fly   966 PLHSCALACAEKPELQQYLDERR-LELQQLLPQ------PQRYVEPLVCTAQGKRVCLTR----L 1019
              ....:.|  .|.|.::||:.. |:..|:..:      |.|.:...|...:|.:..:||    |
Human  1064 --QISYVTC--NPTLDKFLDQTEVLQRAQIFKKNCKAMFPNRRIVTTVFNDEGIQFLVTRYIKAL 1124

  Fly  1020 MDPVPLPPAAVPSGENPLEICIRYVSLLSHLRSYDPCQGFRGVWLDNQSLLDSTWCSVKDLGVLL 1084
            ..|..|....:.:.....::..|:|||:..:.:.........:|:.::..:.....:.::..:||
Human  1125 NPPQQLLDIFLHNSNATFDLIARFVSLIPFVPNTPDENDGSDIWMTSEHCISLAIGNKEEHAILL 1189

  Fly  1085 CNYMLSLGLECWLILGVSCPHGECSFVLFRQPETAELFLVSPATGKRYQLQDVHCPLRRIYCVVG 1149
            ||:.|..|.:..::||.|...|..::|:.:  ||.|..|.:|:||:.|:..|..|||:.:.|:..
Human  1190 CNFFLYFGKKALVLLGTSVLEGHVAYVVTQ--ETNEYLLWNPSTGQCYKQFDPFCPLKSVDCLFD 1252

  Fly  1150 KQNIYFNIQTETRVSMTHFNLQDGACWFPLFRRRVPAPQ-SGVQKLDYAYKRSYE--LSQLQKHI 1211
            .:|::||||.........|:....:.|..|..:.|...: ..:|..:..|..:.:  :..|:..|
Human  1253 DRNVWFNIQQNNTPMAVFFDYSKESFWKQLLPKNVQGTKIQSIQPEEIIYFETDKSMVEDLRNRI 1317

  Fly  1212 ERKIMKKISAWRTTRKTIWNRAFQPRLHKILCDMEDLSTFSRGRYDEPIFSEQLEREFPNYRLYG 1276
            ||.:..|:..||....|.|||.....|.:||..:|    |..|.:.......:.||....|.:.|
Human  1318 ERTLKSKVMEWRPKHPTHWNRQCTFILRQILPKLE----FGIGSFVSSEGDNEFERILQFYWVTG 1378

  Fly  1277 FTLNFAYTNLAAISERIRTSCIHYNHDASVEFCVAVHLHAHANDVLSVWLFLLSMV 1332
            |.:...|.::.:|.:.:..:.||.......||.:||::|.:.|::||||::|.|:|
Human  1379 FPIQMPYIDVQSIIDAVYQTGIHSAEFPQTEFALAVYIHPYPNNILSVWVYLASLV 1434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cc2d2a	NP_611229.2	COG4913	<231..>352	CDD:443941	31/131 (24%)
		CC2D2AN-C2	421..>545	CDD:464780	29/133 (22%)
		C2	<824..917	CDD:425499	28/103 (27%)
CC2D2B	NP_001335937.1	DUF5523	22..267	CDD:465443	50/260 (19%)
		CC2D2AN-C2	470..637	CDD:464780	41/198 (21%)
		C2	900..>945	CDD:472691	16/44 (36%)