Protein Alignment Cc2d2a and Cc2d2a

DIOPT Version :10

• Sequence 1: NP_611229.2
• Gene: Cc2d2a / 36982
• FlyBaseID: FBgn0263113
• Length: 1336
• Species: Drosophila melanogaster
• Sequence 2: XP_036020946.1
• Gene: Cc2d2a / 231214
• MGIID: 1924487
• Length: 1656
• Species: Mus musculus
• Alignment Length: 1487
• Identity: 363/1487 - (24%)
• Similarity: 634/1487 - (42%)
• Gaps: 300/1487 - (20%)

  Fly    57 GFEGEMQQENDFAVEDCQESDEDSGGELAEE---PTDSPSQTFIHIDLHDPPLAWGQLFKQRHYY 118
            |.||...||.....|:    :|...|:.||:   ..|..:..|:.:...:...|..||.|::
Mouse   256 GEEGTQAQERAKKTEE----EELLNGKDAEDFLLGLDPTAHDFVAVRAAEYKSARIQLQKEK--- 313

  Fly   119 DESLLYRPSNTLHFQLHLSDLSELKDS-QIRML-------NRYQEQSKSKSGKLGSDLIGQLSG- 174
              .:|:.||     :|.:....:|.:: |.|.|       ....|.:::....:.:.|:.|..|
Mouse   314 --EILFTPS-----RLTVPTYKKLPENIQPRFLEDEGLYIGARPEVARTNENIMENRLLIQEPGS 371

  Fly   175 -----------------------------QKPASFLMGKHLYRSV---CHRRFQSVFFPPMPPSE 207
                                         |.|.:.|  :.||:..   .|.| |.:.....||..
Mouse   372 KWFGDDGRILALPSPIKPFPSRPSLTTREQSPKAGL--ETLYKKAEKYVHSR-QHMIGSGDPPGN 433

  Fly   208 LKGLPSRRCLKLCLKQLRFSLHPQLLEEHRLAQQLEDLFDVYSQQRKQRICRKLREELEIARQVA 272
            .:       |.:.:..|.|:.||....||.||.:|..|:|.|..::::...:.|.::|:..|:..
Mouse   434 FQ-------LDIDISGLIFTHHPCFSREHVLASKLAQLYDQYLARQQRNKTKFLTDKLQALRKAV 491

  Fly   273 LKLL--------ASAGQDQTAEVKRQLKLTRQLRQRYYAESAAQRNLLQRLLKEWAKLKELRRQQ 329
            ...|        ....|....|.|.:::.||:||.   ||....|.||:.::|.|.::|.||..|
Mouse   492 QTSLNPEKPHQSLDTTQKTINEYKSEIRQTRKLRD---AEQEKDRTLLKTIIKVWKEMKSLREFQ 553

  Fly   330 RFQCTRFQLGLRVVH-PPDLEASYCAWKESFETDLAEVYREHLELFYTRLRLWTDQKSHS----- 388
            ||..|..:|.||... .|.|:..  |::...:.::.|:..||:|.:.|::..:  :.||.
Mouse   554 RFTNTPLKLVLRKEKVDPKLDED--AYEAEIQAEIHELLEEHMEEYATKMEEY--RTSHQQWKAW 614

  Fly   389 RTATGHSKPPRKPQFDRIMASLRKEYDKTF----------KDPEEPYVEVFRLHADEATAR---- 439
            |.|....|..:|...:..:.  .:|.:::|          .:|.:|.|...::....|.:|
Mouse   615 RKAQRAKKKKKKQTTEEHLE--EEEAEESFPEEEVTKPIPPEPTDPAVIEQQVRERAAHSRRRPG 677

  Fly   440 -------LSIPG----GDQLPKA----------RNYFLKIFLDGQFVGQSRTYRLEPDLQISINE 483
                   ||:.|    .||.|:.          |:.:||:..:.:.|.::.:..|..|.::...:
Mouse   678 EPTLIPELSLAGNVTPNDQCPRVEVSRREDVRRRSVYLKVVFNSKEVSRTVSRPLGADFRVHFGQ 742

  Fly   484 CIGVLLERSLPENLNIWLYEK-----STLTPKSRRLAQISTPL---VLSSKDDAVQE-------- 532
            ...:.: .:.||:|.:.:||.     :||      ||::..|:   .|.:....::|
Mouse   743 IFNLQI-FNWPESLMLQVYETIGHSGTTL------LAEVFLPIPETTLVTGRAPIEEVEFSSNQH 800

  Fly   533 ------------KLSFQALSSTQL----AGDVYLYYEYRSTE--------------GWGSALH-- 565
                        ..||:|..|.||    :|.|.....:...|              |:.|||.
Mouse   801 VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAVGENGIPLIPPLSQQNIGFRSALRRA 865

  Fly   566 ----------LDDVQRLPDALRQTLL----PQSLPALPQASKELVTPRPPSGRIKKSQLPSLIFA 616
                      |.|:::|.....::.|    |...|.:     :|::. ..||   :|.:|.....
Mouse   866 DAISSIGTSGLTDMKKLAKWAAESKLDPNDPNHAPLM-----QLISV-ATSG---ESYVPDFFRL 921

  Fly   617 E---QQLQFCGLDVLLDNRRFQLLHSRHQQ----RNLHTKQLRFVPALEQEISE------EEPLP 668
            |   |:..|...:.|..::||:|||.|.|:    ||.  ||   :||.::||.|      |:.|.
Mouse   922 EQLQQEFNFVSEEELNRSKRFRLLHLRSQEVPEFRNY--KQ---IPAYDREIMEKVFQDYEKRLR 981

  Fly   669 DGRGTVQLLEPGTYWNPIDLHKHRGRKFLQLLYEVIASQ--SARRAKALQTPLPLLLLAEDSDRS 731
            | |..::..:      .:|:|:....|:||.:.|.:.::  :|:....|..    |::.|:....
Mouse   982 D-RNVIETKD------HLDMHRATVAKYLQQVREAVVNRFLTAKHHFLLTD----LVVEEEVPNI 1035

  Fly   732 SGTGWTALWRAFCSVFQGQRNSLPREPSGWSGHQ--SAPDLFK-SFCVSLHVVRATGVPVR---- 789
            |..|...|..:...:.:.:|...||.    .|.:  :|.:|.. ...:.::::||..:|||
Mouse  1036 SSEGSGILGLSLFKLAEQKRPLRPRR----KGRKKVTAQNLSDGDIKLLVNIIRAYDIPVRKPVV 1096

  Fly   790 ------SRHILNLNERRSSAGGDMSTSLFVTQTLMYSNVRPFVTLSYGQRLCRSRTAEGSNPTWN 848
                  ||.....:|:::::....|........|....|||||.:|:.:.:|.:.||||.||:||
Mouse  1097 SKFQQPSRSSRTFSEKQTASPSTHSPLHNADYPLGQVLVRPFVEVSFQRTICHTTTAEGPNPSWN 1161

  Fly   849 EQLQLQIQSQFGD--------LRDDLKISLFDELIEQQYSDE---ASDVYQRVQCNWLGEFRVPI 902
            |:|:|..::..||        ::||:.|::|||::.....|:   .|.::.|::.:|||..::|.
Mouse  1162 EELELPFRAPNGDYSTASLQSVKDDVYINIFDEVLYDILEDDRERGSGIHTRIERHWLGCVKIPF 1226

  Fly   903 NSLLASRTFEGCIELAMPKVLVGYKRPLIDSVTNMPTDQYPEFKEAVHLWFYLSIEPGGGDLAPL 967
            :::......:|..::.:|.||:||.:.. :.:.....|......|..::..:::|||   .|.|
Mouse  1227 STIYFQARIDGTFKIDIPPVLLGYSKER-NIIMERAFDSARSLSEGSYITLFITIEP---QLVP- 1286

  Fly   968 HSCALACAEKPELQQYLDERRLELQQ------LLPQPQRYVEPLVCTAQGKRVCLTRLMDPVPLP 1026
               .....||.:.|:  ||:.|:..:      .|..|||.....|....||.|.:||.:.|:. |
Mouse  1287 ---GEPMREKFDTQE--DEKLLQATEKFQAECALKFPQRQCLTTVTDMTGKTVFITRYLKPLN-P 1345

  Fly  1027 PAAV----PSGENP---LEICIRYVSLLSHLRSYDPCQGFRGVWLDNQSLLDSTWCSVKDLGVLL 1084
            |..:    |:  ||   .|:..|||||:..|.......|...:|..:...||......::..|||
Mouse  1346 PQELLHVYPN--NPQATAELVARYVSLIPFLPDSVSFAGVCDLWSTSDQFLDLLAGDEEEHAVLL 1408

  Fly  1085 CNYMLSLGLECWLILGVSCPHGECSFVLFRQPETAELFLV-SPATGKRYQLQDVHCPLRRIYCVV 1148
            |||.|.||.:.||::|.:.|.|..::||..:   ...:|: :|.:|..|...|..|||:.:.|::
Mouse  1409 CNYFLFLGKKAWLVMGSAIPEGPTAYVLTWE---KNYYLIWNPCSGHCYGQFDAFCPLKSVGCLI 1470

  Fly  1149 GKQNIYFNIQTETRVSMTHFNLQDGACWFPLFRRRVPAP-QSGVQ--KLDYAYKRSYELSQLQKH 1210
            |..||:||||........:|::.....|...|.|.:|.| .|.||  :|.|.:......::||..
Mouse  1471 GPDNIWFNIQHHDSPLRINFDVTKPKLWKSFFSRSLPYPGLSSVQPEELIYQHTDKAVAAELQDR 1535

  Fly  1211 IERKIMKKISAWRTTRKTIWNRAFQPRLHKILCDMEDLSTFSRGRYDEPIFSEQLEREFPNYRLY 1275
            ||:.:.:||..||....|.|||.....|...|..:|.    |:|...|.....:|.::..:||..
Mouse  1536 IEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLER----SQGEDIEDDHRAELLKQLGDYRFS 1596

  Fly  1276 GFTLNFAYTNLAAISERIRTSCIHYNHDASVEFCVAVHLHAHANDVLSVWLFLLSMV 1332
            ||.|:..|:.:..:.|.:.::.:|.....:|||.:||::|.:..:|||||:::.|:|
Mouse  1597 GFPLHMPYSEVKPLVEAVYSTGVHNIDLPNVEFALAVYIHPYPKNVLSVWIYVASLV 1653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cc2d2a	NP_611229.2	COG4913	<231..>352	CDD:443941	38/129 (29%)
		CC2D2AN-C2	421..>545	CDD:464780	35/180 (19%)
		C2	<824..917	CDD:425499	32/103 (31%)
Cc2d2a	XP_036020946.1	DUF5523	137..413	CDD:465443	38/200 (19%)
		CC2D2AN-C2	676..850	CDD:464780	50/242 (21%)
		C2	<1133..>1171	CDD:472691	7/37 (19%)