Protein Alignment Cc2d2a and Cc2d2a

DIOPT Version :10

• Sequence 1: NP_611229.2
• Gene: Cc2d2a / 36982
• FlyBaseID: FBgn0263113
• Length: 1336
• Species: Drosophila melanogaster
• Sequence 2: XP_061511225.1
• Gene: Cc2d2a / 1279229
• VectorBaseID: AGAMI1_005029
• Length: 1451
• Species: Anopheles gambiae
• Alignment Length: 1497
• Identity: 432/1497 - (28%)
• Similarity: 675/1497 - (45%)
• Gaps: 259/1497 - (17%)

  Fly     2 EAALSRKTAKKKRKTHTTRGYRKREQEV------QKLIRATEGRISGP-EHDMEALSLQFFHGFE 59
            :|::..:...|.||......:.:.|:||      .|:....:|..|.| .|:::...|    .|.
Mosquito    47 DASVRAERDHKPRKAKVDPRFLQEEREVIASLERLKVTSDVDGANSKPLLHEIDRAIL----FFT 107

  Fly    60 GEMQQENDFAVEDCQ----------------ESDEDSGGELAEEPTDSPSQTFIHIDLHDPPLAW 108
            ..:..|..|..||.:                .|...|....|:.||...|..|...|.....:.|
Mosquito   108 DVLPDEEFFDAEDTEPEAALPIGADEVLQKTPSPRSSSSNEADTPTHLASSYFQAEDGTPVVVPW 172

  Fly   109 GQLFKQRHYYDESLL-YRPSNTLH------FQLHLSDLS-ELKD-----------------SQIR 148
              ..::..:.||.|| |||:.||.      .|:.:.|.: |..|                 ::.|
Mosquito   173 --KLQKYTFCDEDLLYYRPAATLPESRATLEQVCVIDPNVETSDMEGDCARRIEKPPVSVANKNR 235

  Fly   149 MLNRYQEQSKSKSGKLGSDLIGQLSGQKPASFLMGKHLYRSVCHRRFQSVFFPPMPPSE-LKGLP 212
            |:||..|:.:.:    ..|..|:|...:  .::..:...|..|.:.|...|..|||.:: |:.||
Mosquito   236 MMNRLLEEEQEE----WFDASGELVDFR--CYIESQTRVRGFCSKTFVPFFVEPMPLAKTLERLP 294

  Fly   213 SRRCLKLCLKQLRFSLHPQLLEEHRLAQQLEDLFDVYSQQRKQRICRKLREELEIARQVALKLLA 277
            ..|.:|:.:.::||..||.|.|..||..::.:|:..|.:.||..     |:|   |.|..|..|.
Mosquito   295 MERTVKILIGRVRFDAHPSLEEVVRLRLRIVELYKQYYRIRKLN-----RKE---ALQAKLDELR 351

  Fly   278 SAGQDQTAEVKR--------QLKLT-RQLRQRYYAESAAQRNLLQRLLKEWAKLKELRRQQRFQC 333
            ....|...|::.        :.|:| |:.|...|.|...:|:|.:::|:.|   :||:.:.:..|
Mosquito   352 DGSGDAGEELQEPEEPIDSYEKKMTRREYRNLLYQEIRTERHLAKQILELW---EELKAKHQDGC 413

  Fly   334 TRFQLGLRV-VHPPDLEASY--CAWKESFETDLAEVYREHLELF---------YTRLRLWTDQKS 386
                 ||:: |:..|.:...  ..|:|.:|.:|.|...|..||:         |.|     |...
Mosquito   414 -----GLKMSVNSQDTDEDRDGSDWQERYELELRETLEEEQELYQRDKQEYKAYLR-----DLAL 468

  Fly   387 HSRTATGHSKP----PRKPQFDRIMASLRKEYDKTFKDPEEPYVEVFRLHADEATARLSIPGGDQ 447
            ..||....|.|    |:||...:|....|..:|:||:.|.||.|::. |..|:  .|.|.|.|
Mosquito   469 EHRTDINESVPSMQKPKKPDVGKIKKEFRVLFDETFRAPGEPLVDIV-LRRDQ--ERRSDPSG-- 528

  Fly   448 LPKARN--YFLKIFLDGQFVGQSRT--YRLEPDLQISINECIGVLLERSLPENLNIWLYEKSTLT 508
            :|..|:  :.:|:|:|...|..:|.  :..|....|..|....:.|...:||.:.:.||||:.:.
Mosquito   529 VPSGRDLLFKMKLFIDNNHVASTRARHFETEDRTMIDFNTSFSIKLTTKIPETIALHLYEKNRMM 593

  Fly   509 PKSRRLAQISTPLVLSSKDDAVQEK--LSFQALSSTQLAGDVYLYYEYRSTEGW-----GSALHL 566
            .||:| |::..|  |.|.|:..::.  :.:|..|........|.........||     ||....
Mosquito   594 MKSKR-AELFLP--LPSSDELYEDMDFVDYQFSSGKPYQAQTYTNGTVELRIGWMEPSDGSFPSP 655

  Fly   567 DDVQRLPDALRQTLLPQSL---------------------PALPQASKEL--VTPRPPSGRIKK- 607
            ...:.:|   ::.::|:.|                     .||.:|..|.  .|.:....|..|
Mosquito   656 SQRRTVP---KRVVVPRELLRRWIDDRALDSENEPNAGTDAALLRALNETEPTTSQERDRRRSKD 717

  Fly   608 -------SQLPSLIFAEQQLQFCGLDVLLDNRRFQLLHSRHQQRNLHTKQLRFVPALEQEIS--- 662
                   |.....:|.|..|.||..:.:..|.|..:| |:..|.:|..:..:|:|..|:|::
Mosquito   718 STQAADESDETEFLFNEDLLAFCSEETIEQNERLNML-SKRFQCSLKYRDAKFIPQTERELAVDG 781

  Fly   663 -EEEPLPDGRGTVQLLEPGTYWNPIDLHKHRGRKFLQLLYEVIASQSARRAKALQTPLPLLLLAE 726
             ||:       ::::::.....:||||.:|||::.||.:|:.| |...|.....:.....||:..
Mosquito   782 IEEQ-------SMKIIDETLGTDPIDLQRHRGKRHLQKVYDTI-SNHCRVLNQDKVNNANLLVGG 838

  Fly   727 DSDRSSGTGWTALWRAFCSVFQGQRNSLPREPSGWSGHQSA----PDLFKSFCVSLHVVRATGVP 787
            |...|.|    :|..||..:|..:|   |.:||..|.:..|    .|:.: |.:.:.:|||.|:|
Mosquito   839 DQVPSFG----SLSLAFLEIFGPRR---PLKPSRRSPNSRASVRVSDVTR-FKIIVTIVRAFGIP 895

  Fly   788 VRSRH-----ILNLNERRSSAGGDMSTSLFVTQTLMYSNVRPFVTLSYGQRLCRSRTAEGSNPTW 847
            :|...     :...|...||:.|..|   |.|     |||||::.:|...|:.|:.||:|:.|||
Mosquito   896 MRMEDYQTGAVGRRNSNMSSSNGRFS---FRT-----SNVRPYIAVSLKDRIFRTSTADGTAPTW 952

  Fly   848 NEQLQLQIQSQFGDLRDDLKISLFDELIEQQYSDE---ASDVYQRVQCNWLGEFRVPINSLLASR 909
            ||||::.:......:|..|.|.|:||.:|....|:   .::||||:...|||:.|:||:::..::
Mosquito   953 NEQLEVPLDCSTDQIRKHLHIDLYDEYMEDLLEDDRTRPTEVYQRISSRWLGQLRIPISTIYLNQ 1017

  Fly   910 TFEGCIELAMPKVLVGYKRPLIDSVTNMPTDQY------------------PEFKEAVHLWFYLS 956
            ..||..|:..|.:|.||.|.:.|..|....|.|                  |:.:|..|:..::|
Mosquito  1018 RLEGTFEIKTPPILFGYDRQMQDHPTTELVDNYGNPIGLLGGGVGTGVSGLPDMRELTHVTLFIS 1082

  Fly   957 IEP---------GGGDLAPLHSCALACAE----KPELQQYLDERRLELQQLLPQPQR-YVEPLVC 1007
            :||         ||          |.|.|    |..:..:.:|.|.|.      |.| .|.|:|.
Mosquito  1083 LEPLIERPSLDTGG----------LECVELERIKTRIYLWYEEYRHEF------PSRAVVPPMVT 1131

  Fly  1008 TAQGKRVCLTRLMDPVPLPPAAVPSGENPLEICIRYVSLLSHLRSYDPCQGFRGVWLDNQSLLDS 1072
            ...|||:|.|||:.|:|:|   .|..|....:..|||||:....|.|||....||||.|:.:|..
Mosquito  1132 LLGGKRICATRLLGPLPIP---FPIDELAETMIRRYVSLIPVHYSVDPCSQLSGVWLTNKEILTM 1193

  Fly  1073 TWCSVKDLGVLLCNYMLSLGLECWLILGVSCPHGECSFVLFRQPETAELFLVSPATGKRYQLQDV 1137
            ...|.|||||||..:.|.||.|.|||.|.|...|:.:|||..  :..|.|:|.|.:||||...|.
Mosquito  1194 MCGSPKDLGVLLACFYLQLGYEVWLIFGNSVLMGDTTFVLLL--DGGEFFVVDPCSGKRYSSTDT 1256

  Fly  1138 HCPLRRIYCVVGKQNIYFNIQTETRVSMTHFNLQDGACWFPLFRRRVPAPQSGVQKLDYAYKRSY 1202
            :|||.|||.:||..|::.|||.|.||.:|..:::....|..||.|....|...||:..:.::.:.
Mosquito  1257 YCPLNRIYLIVGPDNVWGNIQKENRVFLTQLDVRKSGYWRALFNRFHEPPVGCVQEASFPFREAL 1321

  Fly  1203 ELSQLQKHIERKIMKKISAWRTTRKTIWNRAFQPRLHKILCDME-DLSTFSRGRYDEPIFSEQLE 1266
            ...:||:.||||:|:||::|||.|||:|||.....|...|..:| |....:........||:.
Mosquito  1322 PAKELQRAIERKLMRKIASWRTQRKTVWNRFISDHLRSTLISLERDTCLQANTERHAEAFSQM-- 1384

  Fly  1267 REFPNYRLYGFTLNFAYTNLAAISERIRTSCIHYNHDASVEFCVAVHLHAHANDVLSVWLFLLSM 1331
              |.:|::.||.:|..|.||:.|...::.:.||.|.:|:|||.:.||:..:..:|.|||:||:|:
Mosquito  1385 --FISYKVNGFPINLPYNNLSTIVAHVKGTGIHLNSEAAVEFALGVHIKDYPCNVYSVWIFLMSL 1447

  Fly  1332 VP 1333
            ||
Mosquito  1448 VP 1449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cc2d2a	NP_611229.2	COG4913	<231..>352	CDD:443941	33/130 (25%)
		CC2D2AN-C2	421..>545	CDD:464780	37/129 (29%)
		C2	<824..917	CDD:425499	34/95 (36%)
Cc2d2a	XP_061511225.1	None