DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3b and eif3ba

DIOPT Version :9

Sequence 1:	NP_611228.1	Gene:	eIF3b / 36981	FlyBaseID:	FBgn0034237	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_001277022.1	Gene:	eif3ba / 796380	ZFINID:	ZDB-GENE-030131-2748	Length:	681	Species:	Danio rerio

Alignment Length:	677	Identity:	345/677 - (50%)
Similarity:	472/677 - (69%)	Gaps:	23/677 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DYQEEPNFDDPPGFVDNISDEDLLGDMLAQRPSEADGVESVVVVDNIPKVEPVRLEKLKLVINKL 82
            |.:|||:|.||..|.|:|||::||||:|..:|.||||::||:||||:|:|.|.||||||.||:|:
Zfish    14 DDEEEPSFSDPEDFDDDISDQELLGDVLRDKPQEADGIDSVIVVDNVPQVGPDRLEKLKNVIHKI 78

  Fly    83 FSNYGEIVNVVYPVDEEGKTKGYAFMEYKQARQAEEAVKKLNNHRLDKNHTFAVNLFTDFQKYEN 147
            ||.:|:|.|..|| |.:||||||.|:||.....|.||||..:.::|||.|||.|||||||.||.:
Zfish    79 FSKFGKITNEFYP-DADGKTKGYIFLEYSAPSHAHEAVKNADGYKLDKQHTFRVNLFTDFDKYMS 142

  Fly   148 IPEKWEPPTVQTFKVQSDLYNFINDPDTYDQYCVAAETAPNCVQVGFWQNVLPEPFELETRERFT 212
            |.::||.|..|.||...:|.:::.|||..|||.|..::..   :.|.:.|.:.||.|:|.|.|:|
Zfish   143 ICDEWEAPEKQPFKDFGNLRHWMEDPDCRDQYSVIYDSGE---RTGIFANDVKEPIEVEERARWT 204

  Fly   213 DTFVKWSPLGTYVVTFHKPGVAIWGGSSFQKIQKFPHPGTQFVEFSPCENYLVTYGP----TPTG 273
            :|:|:|||.|||:.|||:.|:|:|||..|::||:|.|.|.|.::|||||.|:||:.|    ....
Zfish   205 ETYVRWSPKGTYLATFHQRGIALWGGEKFKQIQRFSHQGVQLIDFSPCERYVVTFSPLMDTKDDP 269

  Fly   274 QKIIIWDIRTGAEKRSFVADGMSVLSMFRWSHDDKFVARMGENSIHIYETPSFYLLDLKSIKIPG 338
            |.|||||:.||.:||.|..:..:...:|:||.|.||.|||.::.:.||||||..||:.||:||.|
Zfish   270 QAIIIWDVLTGQKKRGFHCESSAHWPIFKWSPDGKFFARMTQDMLSIYETPSMGLLEKKSLKING 334

  Fly   339 IRGFSWSPTDNVIAYWVEEQNQIPARVTLMEIPKKREIRNKNLFHVADCKLHWQKSGDYLCVKVD 403
            |:.|||||.||:||:||.|...||||||||:.|.:.|:|.:|||:|.||||||||:|||||||||
Zfish   335 IKDFSWSPGDNIIAFWVPEDKDIPARVTLMQFPSRNEMRVRNLFNVVDCKLHWQKNGDYLCVKVD 399

  Fly   404 RYSKLKKDKKDLDVKFLGMFYNFEIFHMREKEIPVDSVEIRELILAFAWEPVGNKFSIIHGETNS 468
            |..|..:          |:..|||||.||||::|||.||:::.|:||||||.|:||:::|||:..
Zfish   400 RTPKGTQ----------GVVTNFEIFRMREKQVPVDVVEMKDSIIAFAWEPNGSKFAVLHGESPR 454

  Fly   469 SNVSFYEVNKGVKPSLVKRLEKKSCTHLFWSPRGQFIVMANLTM--GTFEFVDSTNDYIITASPD 531
            .|.|||.|....|..|:|..:|:....:||||:|||:|:|.|..  |...||| |:|..:....:
Zfish   455 INSSFYHVKSNGKIDLIKMFDKQQANSIFWSPQGQFLVLAGLRSMNGALAFVD-TSDCTMMNIAE 518

  Fly   532 HFRASEVEWDPTGRYVVTGVSSWKVKEDTGFNMYTFQGRIIKRTILKNFVQFLWRPRPPTLLSEE 596
            |:.||:||||||||:|||.||.|..|.|..|.::|||||::::...:.|.|.|||||||:||::|
Zfish   519 HYMASDVEWDPTGRFVVTSVSWWSHKVDNAFWLWTFQGRLLQKNNKERFCQLLWRPRPPSLLTQE 583

  Fly   597 KQKEIKKNLKKYYAAFEQKDRLRLTRASKELLEKRSQLRETFMEYRNKRIAEWAEQKSRRIMLRG 661
            :.|.|||:||||...|||||||..::|||||::||..:.|.:.::|.:.:..:.||:..|:.|||
Zfish   584 QIKLIKKDLKKYSKIFEQKDRLSQSKASKELVDKRRTMMEEYRKHRKRAMDMYQEQRPLRLELRG 648

  Fly   662 HVDTDNLET--DEVDEEIVEFLVKEEV 686
            .||||.|::  |:.:||.:||.:.||:
Zfish   649 GVDTDELDSNVDDWEEETIEFFINEEI 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3b	NP_611228.1	WD40	<216..352	CDD:295369	72/139 (52%)
		WD40 repeat	216..248	CDD:293791	18/31 (58%)
		WD40 repeat	297..321	CDD:293791	9/23 (39%)
		RRM_eIF3B	56..137	CDD:240724	46/80 (58%)
		COG5354	194..690	CDD:227657	252/501 (50%)
eif3ba	NP_001277022.1	RRM_eIF3B	52..132	CDD:240724	46/80 (58%)
		COG5354	176..673	CDD:227657	252/510 (49%)
		WD40	206..447	CDD:295369	137/250 (55%)
		WD40 repeat	208..239	CDD:293791	18/30 (60%)
		WD40 repeat	244..291	CDD:293791	21/46 (46%)
		WD40 repeat	297..331	CDD:293791	19/33 (58%)
		WD40 repeat	373..413	CDD:293791	26/49 (53%)
		WD40 repeat	424..473	CDD:293791	24/48 (50%)
		WD40 repeat	480..515	CDD:293791	16/35 (46%)
		WD40 repeat	522..552	CDD:293791	19/29 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591963
Domainoid	1	1.000	265	1.000	Domainoid score	I1860
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2780
Inparanoid	1	1.050	702	1.000	Inparanoid score	I645
OMA	1	1.010	-	-		QHG54076
OrthoDB	1	1.010	-	-		D1194797at2759
OrthoFinder	1	1.000	-	-		FOG0003562
OrthoInspector	1	1.000	-	-		otm26319
orthoMCL	1	0.900	-	-		OOG6_101924
Panther	1	1.100	-	-	O	PTHR14068
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2436
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910