Protein Alignment eIF3b and CG7414

DIOPT Version :9

• Sequence 1: NP_611228.1
• Gene: eIF3b / 36981
• FlyBaseID: FBgn0034237
• Length: 690
• Species: Drosophila melanogaster
• Sequence 2: NP_001137996.2
• Gene: CG7414 / 40431
• FlyBaseID: FBgn0037135
• Length: 638
• Species: Drosophila melanogaster
• Alignment Length: 571
• Identity: 119/571 - (20%)
• Similarity: 206/571 - (36%)
• Gaps: 140/571 - (24%)

  Fly   190 VQVGFWQNV-LPEPFE----LETRERFTDTFVKWSPLGTYVVTFHKPGVAIWGGS-----SFQKI 244
            |.|..|.:. ..:|||    |...|..:...:.:|..|.|....:...|.:...|     |:..|
  Fly    18 VAVELWSSAGSKQPFEHKPHLPREETKSSRSICFSSNGRYFAYSNGQEVKVLQASRDSAASWPVI 82

  Fly   245 QKFPHPGTQFVEFSPCENYLVT---YGPT---PTGQ-KIIIWDIRTGAEKRSFV----ADGMSVL 298
            ...|.|...:::|||..:||.|   |..|   |.|. .::::::.||.|..:.|    ||...
  Fly    83 CVLPRPKAFYLQFSPRGSYLCTWEHYAITKDRPEGSPNLLVYEVATGVEVFAIVQKNQADWQP-- 145

  Fly   299 SMFRWSHDDKFVA----------RMGENSIHIYETPSFYLLDLKSIKIPGIRG--FSWSPTD--N 349
               .||.|:...|          .:||.:...:.|        .|.||.|.||  .|..|.:  .
  Fly   146 ---SWSADESIFALVVGGEALFYDLGEGAEKGFAT--------TSRKIGGSRGGMLSLGPGNCPP 199

  Fly   350 VIAYWVEEQNQIPARVTLMEIP---KKREIRNKNLFHVADCKLHWQKSGDYLCVKVDRYSKLKKD 411
            .:|::.......|:...|.:.|   :.:.:..|:.|.....::.|.|.|..|.:    .:..:.|
  Fly   200 FLAFYTPGAKGAPSMCKLYKYPALGQNQTVACKSFFQADRVEMLWNKRGSGLLL----LTSTEVD 260

  Fly   412 KKDLDVKFLGMFYNFEIFHMR-----------EKEIPVDSVEIRELILAFAWEPVGNKFSIIHGE 465
            |..      ..:|..:..|..           .||.||..|:         |.|...:|.:::|.
  Fly   261 KSG------ASYYGNQAVHFMATKGDTCSVPLSKEGPVHCVK---------WSPKATEFVVVYGF 310

  Fly   466 TNSSNVSF-------YEVNKGVKPSLVKRLEKKSCTHLFWSPRGQFIVMA---NLTMGTFEFVDS 520
            ..|....:       ::..:|          .::|.  :::|.|..|.:|   ||. |..|..|.
  Fly   311 MPSKAALYNLKCDVVFDFGEG----------PRNCA--YFNPFGNLIALAGFGNLP-GAVEVWDV 362

  Fly   521 TNDYIITASPDHFRASEV---EWDPTGRYVVTGVSSWKVKEDTGFNMYTFQGRIIKRTILKNFVQ 582
            :....:.    :.:.::.   ||.|.|.:.||..::.:::...||.:|.:.|.::..|:.....:
  Fly   363 SKREKLA----NLKCADTTVFEWHPNGEWFVTATTAPRLRISNGFKVYHYSGALLHETMWPQGQE 423

  Fly   583 FL---WRPRPPTLLSEEKQKEIK---------KNLKKYYAAFEQKDRLRLTRASKELLEKRSQ-- 633
            .|   |:.......||.|..:.|         :..||.|.    ...|||.:..|...:...|
  Fly   424 LLGIEWQQFADKTFSEPKITKAKHEGIKSSQPEASKKAYT----PPHLRLLKEGKNPEKYLPQPS 484

  Fly   634 ---LRETFM------EYRNKRIAEWAEQKSRRIMLRGHVDTDNLETDEVDE 675
               |..|..      ..||.:..:.:.:|...::..|  |.|:..|:.||:
  Fly   485 IPGLAPTAAAGGVNGNKRNNKNKQRSARKDVNVVNGG--DADSAPTEVVDQ 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3b	NP_611228.1	WD40	<216..352	CDD:295369	40/165 (24%)
		WD40 repeat	216..248	CDD:293791	7/36 (19%)
		WD40 repeat	297..321	CDD:293791	6/33 (18%)
		RRM_eIF3B	56..137	CDD:240724
		COG5354	194..690	CDD:227657	117/567 (21%)
CG7414	NP_001137996.2	eIF2A	232..419	CDD:285825	42/222 (19%)
		WD40	<289..391	CDD:295369	25/127 (20%)
		WD40 repeat	292..327	CDD:293791	7/43 (16%)
		WD40 repeat	334..371	CDD:293791	10/43 (23%)
		WD40 repeat	376..399	CDD:293791	6/22 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5354
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D262412at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.820