Protein Alignment eIF3b and Eif2a

DIOPT Version :9

• Sequence 1: NP_611228.1
• Gene: eIF3b / 36981
• FlyBaseID: FBgn0034237
• Length: 690
• Species: Drosophila melanogaster
• Sequence 2: NP_001005509.1
• Gene: Eif2a / 229317
• MGIID: 1098684
• Length: 581
• Species: Mus musculus
• Alignment Length: 559
• Identity: 113/559 - (20%)
• Similarity: 208/559 - (37%)
• Gaps: 118/559 - (21%)

  Fly   211 FTDTFV--KWSPLGTYVVTFHKPGVAIWGGSSFQKI-----------QKFPHPGTQFVEFSPCEN 262
            ||::.|  :.|.....|.||.|.| .::..|:.:|:           ..|..|....:||||...
Mouse    25 FTESTVLPRESGRNCKVYTFSKDG-TLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNT 88

  Fly   263 YLVTYGPTPTGQ-------KIIIWDIRTGAEKRSFVADGMSVLSMFRWSHDDKFVARMGENSIHI 320
            .|.|:.|..|.:       .:.::|::|||..:||:...|..... .||.|:...||...|.:|.
Mouse    89 VLATWQPYTTSKDGTAGTPNLQLYDMKTGACLKSFIQKKMQNWCP-SWSDDEIICARNVNNEVHF 152

  Fly   321 YETPSFYLLDLKSIKIPGIRGFSWSPTDN--VIAYWVEEQNQIPARVTLMEIPK----KREIRNK 379
            :|..:|..:..| :.:..:..|:.||...  .:|.:|......|:.|.|.:.|.    :..:.||
Mouse   153 FENNNFNTIANK-LHLQKVNDFNLSPGTQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANK 216

  Fly   380 NLFHVADCKLHWQKSGDYLCVKVDRYSKLKKDKKDLDVKFLGMFYNFEIFH--MREKEIPVDSVE 442
            :.|......:.|.|....:.|    .:..:.||..      ..:|..:..|  ....|..|..:.
Mouse   217 SFFKADKVTMLWNKKATAVLV----IASTEVDKTG------ASYYGEQTLHYIATNGESAVVQLP 271

  Fly   443 IRELILAFAWEPVGNKFSIIHGETNSSNVSF-------YEVNKGVKPSLVKRLEKKSCTHLFWSP 500
            ....|....|.....:|..::|...:....|       ::...|.:.:            .|:||
Mouse   272 KNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNA------------AFYSP 324

  Fly   501 RGQFIVMA---NLTMGTFEFVDSTNDYIITASPDHFRASEVEWDPTGRYVVTGVSSWKVKEDTGF 562
            .|..:|:|   || .|..|..|..| |.:.:.|....::...|.|.|.:::|...:.:::.:.|:
Mouse   325 HGHILVLAGFGNL-RGQMEVWDVKN-YKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGY 387

  Fly   563 NMYTFQGRII-KRTILKN--FVQFLWRP-------------------------------RPPTLL 593
            .::.:.|.:: |..:..|  ..|..|:|                               |||.|.
Mouse   388 KIWHYTGSLLHKYDVPSNGELWQVSWQPFLDGIFPAKTIKYQAVPSEVPSEEPKVATAYRPPALR 452

  Fly   594 ------SEEKQKEIKKNLKKYYAAFEQKDRLRLTRASKELLEKRSQLRETFMEYRNKRIAEWAEQ 652
                  |:..::|..:|:|.:..:.:...:..|....|...:|.::     .|.|:........|
Mouse   453 NKPVTNSKLHEEEPPQNMKPHPGSDKPLSKTALKNQRKHEAKKAAK-----QEARSDAAPTPVPQ 512

  Fly   653 KSRRIMLRGHVDTDNLETD-EVDEEIVEFLVKEEVTLLE 690
            .:.|     :..|.:...| |||::|..  :|:::..:|
Mouse   513 SAPR-----NTVTQSASGDPEVDKKIKN--LKKKLKAIE 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3b	NP_611228.1	WD40	<216..352	CDD:295369	39/157 (25%)
		WD40 repeat	216..248	CDD:293791	9/44 (20%)
		WD40 repeat	297..321	CDD:293791	7/23 (30%)
		RRM_eIF3B	56..137	CDD:240724
		COG5354	194..690	CDD:227657	112/557 (20%)
Eif2a	NP_001005509.1	WD 1	23..63		11/38 (29%)
		WD40	<41..143	CDD:295369	27/103 (26%)
		WD 2	125..163		10/38 (26%)
		eIF2A	216..411	CDD:285825	39/218 (18%)
		WD 3	356..401		7/44 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..533		20/110 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810