Protein Alignment eIF3b and eif-3.B

DIOPT Version :10

• Sequence 1: NP_611228.1
• Gene: eIF3b / 36981
• FlyBaseID: FBgn0034237
• Length: 690
• Species: Drosophila melanogaster
• Sequence 2: NP_001022469.2
• Gene: eif-3.B / 175138
• WormBaseID: WBGene00001225
• Length: 725
• Species: Caenorhabditis elegans
• Alignment Length: 714
• Identity: 238/714 - (33%)
• Similarity: 378/714 - (52%)
• Gaps: 65/714 - (9%)

  Fly    16 DSDYQEEPNFDDPPGFVDNISDEDLLGDMLAQRPSEADGVESVVVVDNIPKVEPVRLEKLKLVIN 80
            |.:.:.|.:|.|||||||:::|:.|:.|:|.::|:..:..::.|.:..||.|...||.||:.|:.
 Worm     5 DFNKENEEDFSDPPGFVDDVTDDVLVPDVLHKKPTIDEFEDNCVFIAGIPVVGADRLGKLQSVLK 69

  Fly    81 KLFSNYGEIVNVVYPVDEEGKTKGYAFMEYKQARQAEEAVKKLNNHRLDKNHTFAVNLFTDFQKY 145
            |:.......|.:..|...||...|....|:...|.|:.|||.||.:..||||||....|.|.::.
 Worm    70 KVLERLDPAVKLYIPPSPEGGCLGVLLTEWADQRSAQFAVKSLNGYAFDKNHTFTARSFKDMKQL 134

  Fly   146 ENIPEKWEPPTVQTFKVQSDLYNFINDPDTYDQYCVAAET--APNCVQVGFWQNVLPEPFEL--- 205
            |...:.|..|..|.:....||:.::.:....||:.::.:.  .|.   ||.:.|:.....||
 Worm   135 EAPSDHWTTPEKQAYNDVGDLWWWLQNERCRDQFAISHDKLGVPT---VGVFTNMKGNDPELAGD 196

  Fly   206 ---ETRERFTDTFVKWSPLGTYVVTFHKPGVAIWGGSSFQKIQKFPHPGTQFVEFSPCENYLVTY 267
               ..|..:|:|...|||.|:|:.|.||.|:.:|||..:.:..:|.|...|:::|||||.|||||
 Worm   197 ADKAERANWTETVFTWSPHGSYLSTIHKQGIILWGGKDYARAHRFAHTNVQYIDFSPCETYLVTY 261

  Fly   268 -GPTPTG-------QKIIIWDIRTGAEKRSFVA---DGMSVL---SMFRWSHDDKFVARMGE--- 315
             .|..:.       ..:.|||:|||..|::|..   .|.:.|   ..||||.|:|:.|.:..
 Worm   262 AAPEESNSWGDCEKDSLRIWDVRTGELKKAFSTFELTGRTQLPTWPFFRWSFDEKYFACLKAPEK 326

  Fly   316 ---------NSIHIYETPSFYLLDLKSIKIPGIRGFSWSPTDNVIAYWVEEQNQIPARVTLMEIP 371
                     |.|.|:|:..|.|.:.:.:.|..|:.|.||||..|:||:.|..:.:||...|:::|
 Worm   327 DKLEREQKINGISIFESEKFELYEGRPVNIENIKQFEWSPTSTVLAYYSECTDAVPAEFGLLQVP 391

  Fly   372 KKREIRNKNLFHVADCKLHWQKSGDYLCVKVDRYSKLKKDKKDLDVKFL-GMFYNFEIFHMREKE 435
            ..:.:|:..:.:|||.::.|||||..|.....|:.| |:.::..:||:: |..|:.:||.:.:|:
 Worm   392 SMQRLRSARVHNVADAQMFWQKSGKRLAFYTMRFKK-KEYRETGEVKYVGGCQYHVDIFEIDKKD 455

  Fly   436 IPVDSVEIRELILAFAWEPVGNKFSIIHGETNSSNVSFYEVN-KGVKPSLVKRLEKKSCTH---L 496
            :.:.::.:.|..:.|.|:|.|:||.::.|.|..:....|::. ....|.||.:|:  :..|   :
 Worm   456 VSLMNLPLSEPFIHFDWDPEGDKFCVLVGNTAKATPQVYKIEANSHAPKLVSKLD--AGVHFNEV 518

  Fly   497 FWSPRGQFI-VMANLTM-GTFEFVDSTNDYIITASPDHFRASEVE--------WDPTGRYVVT-G 550
            .::|:|.:: |:|.::. |...|:|       |:..:..|.:.:|        |||||||.|| .
 Worm   519 QFAPKGGWLAVLAKVSAGGNVYFID-------TSLSEAKRTNVIEHPLFNKGYWDPTGRYFVTCS 576

  Fly   551 VSSWKVKEDTGFNMYTFQGRIIKRTILKNFVQFLWRPRPPTLLSEEKQKEIKKNLKKYYAAFEQK 615
            ....:...|.|:.::|||||.:.|..|....||.||||||..|||:||:||||||||..|.|.::
 Worm   577 TLGGRAGADLGYRIFTFQGRELCRKNLDRLAQFKWRPRPPVKLSEQKQREIKKNLKKTAAKFIKQ 641

  Fly   616 DRLRLTRASKELLEKRSQLRETFMEYRNKRIAEWAEQKSRRIMLRGHVDTD-NLETDE-VDEEI 677
            |.....|||:|::|||.::...|...|::...:....:..||.||..|||: .|:.|| |||||
 Worm   642 DDDEKCRASQEVVEKRRKIMAAFDIIRSRNREQLDATRDERISLRNGVDTEAQLDEDEFVDEEI 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3b	NP_611228.1	RRM_eIF3B	56..137	CDD:409720	29/80 (36%)
		COG5354	194..690	CDD:227657	181/534 (34%)
eif-3.B	NP_001022469.2	RRM_SF	45..126	CDD:473069	29/80 (36%)
		COG5354	166..658	CDD:227657	168/504 (33%)
		WD40 repeat	208..241	CDD:293791	13/32 (41%)