DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3b and eif-3.B

DIOPT Version :9

Sequence 1:	NP_611228.1	Gene:	eIF3b / 36981	FlyBaseID:	FBgn0034237	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_001022469.2	Gene:	eif-3.B / 175138	WormBaseID:	WBGene00001225	Length:	725	Species:	Caenorhabditis elegans

Alignment Length:	714	Identity:	238/714 - (33%)
Similarity:	378/714 - (52%)	Gaps:	65/714 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DSDYQEEPNFDDPPGFVDNISDEDLLGDMLAQRPSEADGVESVVVVDNIPKVEPVRLEKLKLVIN 80
            |.:.:.|.:|.|||||||:::|:.|:.|:|.::|:..:..::.|.:..||.|...||.||:.|:.
Worm     5 DFNKENEEDFSDPPGFVDDVTDDVLVPDVLHKKPTIDEFEDNCVFIAGIPVVGADRLGKLQSVLK 69

  Fly    81 KLFSNYGEIVNVVYPVDEEGKTKGYAFMEYKQARQAEEAVKKLNNHRLDKNHTFAVNLFTDFQKY 145
            |:.......|.:..|...||...|....|:...|.|:.|||.||.:..||||||....|.|.::.
Worm    70 KVLERLDPAVKLYIPPSPEGGCLGVLLTEWADQRSAQFAVKSLNGYAFDKNHTFTARSFKDMKQL 134

  Fly   146 ENIPEKWEPPTVQTFKVQSDLYNFINDPDTYDQYCVAAET--APNCVQVGFWQNVLPEPFEL--- 205
            |...:.|..|..|.:....||:.::.:....||:.::.:.  .|.   ||.:.|:.....||
Worm   135 EAPSDHWTTPEKQAYNDVGDLWWWLQNERCRDQFAISHDKLGVPT---VGVFTNMKGNDPELAGD 196

  Fly   206 ---ETRERFTDTFVKWSPLGTYVVTFHKPGVAIWGGSSFQKIQKFPHPGTQFVEFSPCENYLVTY 267
               ..|..:|:|...|||.|:|:.|.||.|:.:|||..:.:..:|.|...|:::|||||.|||||
Worm   197 ADKAERANWTETVFTWSPHGSYLSTIHKQGIILWGGKDYARAHRFAHTNVQYIDFSPCETYLVTY 261

  Fly   268 -GPTPTG-------QKIIIWDIRTGAEKRSFVA---DGMSVL---SMFRWSHDDKFVARMGE--- 315
             .|..:.       ..:.|||:|||..|::|..   .|.:.|   ..||||.|:|:.|.:..
Worm   262 AAPEESNSWGDCEKDSLRIWDVRTGELKKAFSTFELTGRTQLPTWPFFRWSFDEKYFACLKAPEK 326

  Fly   316 ---------NSIHIYETPSFYLLDLKSIKIPGIRGFSWSPTDNVIAYWVEEQNQIPARVTLMEIP 371
                     |.|.|:|:..|.|.:.:.:.|..|:.|.||||..|:||:.|..:.:||...|:::|
Worm   327 DKLEREQKINGISIFESEKFELYEGRPVNIENIKQFEWSPTSTVLAYYSECTDAVPAEFGLLQVP 391

  Fly   372 KKREIRNKNLFHVADCKLHWQKSGDYLCVKVDRYSKLKKDKKDLDVKFL-GMFYNFEIFHMREKE 435
            ..:.:|:..:.:|||.::.|||||..|.....|:.| |:.::..:||:: |..|:.:||.:.:|:
Worm   392 SMQRLRSARVHNVADAQMFWQKSGKRLAFYTMRFKK-KEYRETGEVKYVGGCQYHVDIFEIDKKD 455

  Fly   436 IPVDSVEIRELILAFAWEPVGNKFSIIHGETNSSNVSFYEVN-KGVKPSLVKRLEKKSCTH---L 496
            :.:.::.:.|..:.|.|:|.|:||.::.|.|..:....|::. ....|.||.:|:  :..|   :
Worm   456 VSLMNLPLSEPFIHFDWDPEGDKFCVLVGNTAKATPQVYKIEANSHAPKLVSKLD--AGVHFNEV 518

  Fly   497 FWSPRGQFI-VMANLTM-GTFEFVDSTNDYIITASPDHFRASEVE--------WDPTGRYVVT-G 550
            .::|:|.:: |:|.::. |...|:|       |:..:..|.:.:|        |||||||.|| .
Worm   519 QFAPKGGWLAVLAKVSAGGNVYFID-------TSLSEAKRTNVIEHPLFNKGYWDPTGRYFVTCS 576

  Fly   551 VSSWKVKEDTGFNMYTFQGRIIKRTILKNFVQFLWRPRPPTLLSEEKQKEIKKNLKKYYAAFEQK 615
            ....:...|.|:.::|||||.:.|..|....||.||||||..|||:||:||||||||..|.|.::
Worm   577 TLGGRAGADLGYRIFTFQGRELCRKNLDRLAQFKWRPRPPVKLSEQKQREIKKNLKKTAAKFIKQ 641

  Fly   616 DRLRLTRASKELLEKRSQLRETFMEYRNKRIAEWAEQKSRRIMLRGHVDTD-NLETDE-VDEEI 677
            |.....|||:|::|||.::...|...|::...:....:..||.||..|||: .|:.|| |||||
Worm   642 DDDEKCRASQEVVEKRRKIMAAFDIIRSRNREQLDATRDERISLRNGVDTEAQLDEDEFVDEEI 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3b	NP_611228.1	WD40	<216..352	CDD:295369	57/161 (35%)
		WD40 repeat	216..248	CDD:293791	12/31 (39%)
		WD40 repeat	297..321	CDD:293791	10/38 (26%)
		RRM_eIF3B	56..137	CDD:240724	29/80 (36%)
		COG5354	194..690	CDD:227657	181/534 (34%)
eif-3.B	NP_001022469.2	RRM_eIF3B	45..126	CDD:240724	29/80 (36%)
		WD40 repeat	208..241	CDD:293791	13/32 (41%)
		WD40	<211..>296	CDD:295369	34/84 (40%)
		eIF2A	403..609	CDD:285825	62/215 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164178
Domainoid	1	1.000	151	1.000	Domainoid score	I2694
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	381	1.000	Inparanoid score	I1187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54076
OrthoDB	1	1.010	-	-		D1194797at2759
OrthoFinder	1	1.000	-	-		FOG0003562
OrthoInspector	1	1.000	-	-		oto18486
orthoMCL	1	0.900	-	-		OOG6_101924
Panther	1	1.100	-	-	LDO	PTHR14068
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R377
SonicParanoid	1	1.000	-	-		X2436
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.940