Protein Alignment Patronin and Camsap3

DIOPT Version :10

• Sequence 1: NP_001261051.1
• Gene: Patronin / 36978
• FlyBaseID: FBgn0263197
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_001350168.1
• Gene: Camsap3 / 69697
• MGIID: 1916947
• Length: 1280
• Species: Mus musculus
• Alignment Length: 1845
• Identity: 402/1845 - (21%)
• Similarity: 612/1845 - (33%)
• Gaps: 759/1845 - (41%)

  Fly     3 VETQEIRQARQRASVKWLLSKAFN--NRVPDNLKEPFYRDHENQERLKPQIIVELGNATLYC--- 62
            ::..:..:|:..||:.|:|..||.  ..||..|.||||.|...||.:||.:...|.:|.|||
Mouse    24 LDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPFYTDQYAQEHVKPPVTRLLLSAELYCRAW 88

  Fly    63 -QTLANLYSDPNYQSMNHWSIIQTLARKGVPVAESADMPITETVLIQTNPLRINAHMSVIESLMV 126
             |.|..|...|:..     :::..|||:|. |....:.|:.|..| :..|:.:.||::||::|||
Mouse    89 RQALPQLEPSPSPS-----ALLALLARRGT-VPSLPEHPVREADL-KHQPILMGAHLAVIDALMV 146

  Fly   127 LYAKE----------ISSGDR-----VMAAIRRISGNNYQAPTGQSYEQALLG------------ 164
            .::.|          :||.:.     |...:||:.....|....::...|.|.
Mouse   147 AFSFEWTKTLPGPLALSSLEHKLLFWVDTTVRRLQEKTEQEAAQRASPAAPLDGASPAQPSCPTR 211

  Fly   165 --W--ISHACA-ALKKRIIKEVDAGLPDDNGSRLQTPDIPPVRDFQDLCDGICLALLISYYCPKV 224
              |  :.||.| .||:...|........|.....:.|..|.|...|||..|..||..|..|||::
Mouse   212 WYWKLVPHAIAFCLKESGNKPPMIRYRKDRAIARRAPCFPNVTTLQDLASGAALAATIHCYCPQL 276

  Fly   225 VPWTSVRINYLPAVEDSIHNILLVCNFSQKHLPYTVMHMTPEDVTYMRGSMKLNLVVLLTDLFNL 289
            :....|.:....:|.||::|:.||.:|...||| ....::.||:.|:...:|:||||||.:::..
Mouse   277 LRLEEVCLKDPMSVADSLYNLQLVQDFCASHLP-RGCPLSLEDLLYVPPPLKVNLVVLLAEMYMC 340

  Fly   290 FEIHPAKCVCYPGM-DGQVPHSNSFGGGLNRRSTPPNEYQTVQSNNFDGNHAEAFVVHKS----- 348
            ||:.....|....: ||.|             :..|...:||.|.|..|:.:..|.....
Mouse   341 FEVLKPDFVQAKDLPDGHV-------------AVSPRNTETVPSQNNSGSSSPVFNFRHPLLSPG 392

  Fly   349 ------RGIT-TLASMHSQQQQQLHQQQQHQQQYHQQPLQQHPS-------QSQLQIQQQEPLVP 399
                  ||.| :|.|..|....:...:..::|.  .:||.|..|       .|.:.:...:|::
Mouse   393 GPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQL--SRPLSQAVSFSTPFGLDSDVDVVMGDPVL- 454

  Fly   400 ARLRQAKEKTNVESKADERGDFVAAGRPSNWEQSRRPSFAGRRSRRNSSSEDSQL-TIENF---- 459
              ||.....              :.|.|       ||.....|:....:.|...| |||..
Mouse   455 --LRSVSSD--------------SLGPP-------RPVSTSSRNSAQPAPESGDLPTIEEALQII 496

  Fly   460 ---------GGSQDQLNTLGRYERDRERKLSNTSVGSYPVEPAVAVRSSIADARGTLQLGYDTDS 515
                     .|:.|     |.:.......||...:..||.|
Mouse   497 HSAEPRLLPDGAAD-----GSFYLHSPEGLSKPPLSPYPPE------------------------ 532

  Fly   516 GSEK--QDRETEKYSMRRQVSVDNVPTVSSH--NLSNA----------------GSPLPVARHKQ 560
            |:.|  .||            ::..|...||  |.|.:                |||..||
Mouse   533 GASKPLSDR------------LNKAPIYISHPENPSKSSPCSTGEILKPPPPSEGSPKAVA---- 581

  Fly   561 HSSDKDYSSNSGMTPDAYN-----DSRSTSGY-DPESTPVRKSSTSSMPASPAAWQLDVGDDDMR 619
             ||....:|...||..|..     .:.:.||. .|.||||...:.|
Mouse   582 -SSPAANNSEVKMTSFAERKKQLVKAEAESGLGSPTSTPVAPEALS------------------- 626

  Fly   620 SLENASKLSTIRMKLEEKRRRIEQDKRKIEMALLRH---------------------QEKEDLES 663
                 |::|.:..:||||||.||..||:||....:|                     :|:.:|.|
Mouse   627 -----SEMSELGARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREAAGEAEEEAELGS 686

  Fly   664 CP--DVMKWETMSNESKR------TPDMDPV---DLDKYQQSIAIMNMNLQDIQQDIHRLATQQS 717
            .|  :....|.....|.|      :||:.||   .|..|.::::.::..|..:|:|:.||..||.
Mouse   687 VPGGERPAGEGQGEPSLRHKSVTFSPDLGPVPPEGLGDYNRAVSKLSAALSSLQRDMQRLTDQQQ 751

  Fly   718 QMQAQHLQAQQLMQAQQIANMLNQQQTYGSQQHLADHHYQQQRPMQQSFGSSPHLPQAYNAPVSA 782
            ::.|
Mouse   752 RLLA------------------------------------------------------------- 755

  Fly   783 YSSRPPSRDPYQQQLHHQQQQPMPMPQPMQYVNEHGQYMSPPQPAHYMPQQAQQPQSIYSDNGAA 847
                ||             :.|.|.|.|..:|               :|..|..|::
Mouse   756 ----PP-------------EAPGPAPPPAAWV---------------IPGPATGPKA-------- 780

  Fly   848 YNHSNHSPYGGTPQYRSSVVYDDYGQPTNHFYLHESSPQPQAHQHPQRRTWAHSAAAAAYEQQQQ 912
                                               :||.|           |..|.||
Mouse   781 -----------------------------------ASPSP-----------ARRAPAA------- 792

  Fly   913 IQPSLVDVNAWQTQQHQKQKQTWMNRPPSSAGAPSPGSFMLHQNGGGGGGGGGGGELQHLFQVQA 977
                                    .|.|....:|:|                            .
Mouse   793 ------------------------RRSPGPGPSPTP----------------------------R 805

  Fly   978 SPQHGQRQVSGSNGVQRQQSLTNLRDNRSPKAPQNMGMPMGMPMQQEDMMAPQSICFIGDEEDVD 1042
            ||:|.:                          |..:.:   .|:.:  ::.|        ..|||
Mouse   806 SPKHAR--------------------------PAELKL---APLTR--VLTP--------PHDVD 831

  Fly  1043 ELERNIIESMQSTHISDFVHQQQQQHQHQQQLQQQQRLQGHSGRGSSSEDYDSGEMISNKLNITS 1107
            .|          .|:..|
Mouse   832 SL----------PHLRKF----------------------------------------------- 839

  Fly  1108 GNLTYRIPSPSRPSIQANSFQDPRAMAAASGGEDQPPEKGFYISFDDEQPKRPKPPLRAKRSPKK 1172
                    |||:..:|..|        :....|..|||:      ...:|...:.||.:...|..
Mouse   840 --------SPSQVPVQTRS--------SILLSEGTPPEE------PTTKPALIEIPLASLGEPAA 882

  Fly  1173 E-----SPPGSRDSVDNQATLKRESLSHLHNNNNIGFGNDDVNSKPVTRHSIHGLNNSNSVKSPG 1232
            :     ||||:.||::.:|:.:.|..|      .:||
Mouse   883 DEEGDGSPPGAEDSLEEEASSEGEPRS------GLGF---------------------------- 913

  Fly  1233 NATYNKYTDEPPIQLRQLAVSGAMSPTSNERHHLDDVSNQSPQQTQQPMSPTRLQQSSNNAEAAK 1297
               :.|..|:|.
Mouse   914 ---FYKDEDKPE----------------------------------------------------- 922

  Fly  1298 NKALVIGADSTNLDPESVDEMERRKEKIMLLSLQRRQQQ-EEAKARKEIEASQKREKEREKEEER 1361
                              |||.:::..:    |:|:|:: |||:.||:   .|:.||| :|.||.
Mouse   923 ------------------DEMAQKRASL----LERQQRRVEEARRRKQ---WQEAEKE-QKREEA 961

  Fly  1362 ARKKEEQ---------MARRAAILEQHRLKKAIEEAEREG------------------KTLDRPD 1399
            ||..:|.         :|..|.:.......:|:..||.|.                  |.:|  |
Mouse   962 ARLAQEAPGLAFTTPVVASAAPVATLAPTTRAMAPAEEEVGPRRGDFTRLEYERRAQLKLMD--D 1024

  Fly  1400 LHVKLQSHSSTSTTPRLRQQRTTRPRPKTIHVDDASVDISEASSISSRGKKGSS-SNLTGYGQLS 1463
            |...|:..:|.:..|....:|.||||...  .||:::..|.|     ||..||. |.:.....||
Mouse  1025 LDKVLRPRASGTGGPGRGGRRATRPRSGC--CDDSALARSPA-----RGLLGSRLSKVYSQSTLS 1082

  Fly  1464 SNSMKRDYYRGSQDSLTVKDSGLGRATPPRRAPSPGMGMGASGRHMPSPSG-PGSLPPGLISKRR 1527
            .:::..:           ..:.||...|..|||||      ||  :.|||. ||       |:.|
Mouse  1083 LSTVANE-----------APNNLGVKRPTSRAPSP------SG--LMSPSRLPG-------SRER 1121

  Fly  1528 GFDDGSSDFSLTPNLNMEYSGPKLYKQPAAKSNRGIILNAVEYCVFPGVVNREAKQKVLEKIARS 1592
            .:::||:  :.:|....||:||:|||:|:||||:.||.||:.:|...|.||...|.::||:|.:|
Mouse  1122 DWENGSN--ASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKS 1184

  Fly  1593 EAKHFLVLFRDAGCQFRALYSYQPETDQVTKLYGTGPSQVEEVMFDKFFKYNSGGKCFSQVHTKH 1657
            :|.|||:||||:.|||||||:...||:::::|.|.||..|...|.:..:||||..|.|:|:..|.
Mouse  1185 KANHFLILFRDSSCQFRALYTLSGETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKT 1249

  Fly  1658 LTVTIDAFTIHNSLWQGKRVQLPSK 1682
            :::::|||||...|||.|:...|.|
Mouse  1250 MSMSVDAFTIQGHLWQSKKPTTPKK 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Patronin	NP_001261051.1	CAMSAP_CH	189..272	CDD:432229	27/82 (33%)
		CAMSAP_CC1	612..679	CDD:465344	21/89 (24%)
		PRK10263	<741..>898	CDD:236669	13/156 (8%)
		tolA_full	1271..>1391	CDD:274303	26/129 (20%)
		CAMSAP_CKK	1548..1676	CDD:198119	62/127 (49%)
Camsap3	NP_001350168.1	CAMSAP_CH	241..323	CDD:432229	27/82 (33%)
		CAMSAP_CC1	615..672	CDD:465344	21/80 (26%)
		PRK02224	<922..>1020	CDD:179385	27/176 (15%)
		CAMSAP_CKK	1140..1268	CDD:198119	62/127 (49%)