Protein Alignment Patronin and Camsap2

DIOPT Version :10

• Sequence 1: NP_001261051.1
• Gene: Patronin / 36978
• FlyBaseID: FBgn0263197
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: XP_006529895.1
• Gene: Camsap2 / 67886
• MGIID: 1922434
• Length: 1481
• Species: Mus musculus
• Alignment Length: 1846
• Identity: 424/1846 - (22%)
• Similarity: 699/1846 - (37%)
• Gaps: 566/1846 - (30%)

  Fly     7 EIRQARQRASVKWLLSKAF-NNRVPDNLKEPFYRDHENQERLKPQIIVELGNATLYCQT-LANLY 69
            :..:|:...::.||::||| ...||:.|.:|||.|..:||.:||.::..|.:|.|||:. ...|.
Mouse    26 DFSRAKIACNLAWLVAKAFGTENVPEELGDPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILK 90

  Fly    70 SDPNYQSMNHWSIIQTLARKGVPVAESADMPITETVLIQTNPLRINAHMSVIESLMVLYAKEISS 134
            ||.....:.|.::||.||:||:.|.:...: :||..| ...|::::||:::|::||:.|..|:.|
Mouse    91 SDAAKPLLGHDAVIQALAQKGLYVTDQEKL-VTERDL-HKKPIQMSAHLAMIDTLMMAYTVEMIS 153

  Fly   135 GDRVMAAIRRISGNNYQAPTGQSY--EQALLGWISHACAALK----------------------- 174
            .::|:|..::.|. .:|| |...|  |.|::.|::.....||
Mouse   154 IEKVIACAQQYSA-FFQA-TDLPYDIEDAVMYWMNKVNEHLKDIMEQEQKSKEHHPAEAPGGQKS 216

  Fly   175 --KRIIKEVDAGLPDDNGSRLQTPDIPPVRD-FQDLCDGICLALLISYYCPKVVPWTSVRINYLP 236
              |...|.|.|....:.....|.|.||.|.: .:|..||..||.||.:|||.||....:.:....
Mouse   217 PSKWFWKLVPARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPAVVRLEDICLKETM 281

  Fly   237 AVEDSIHNILLVCNFSQKHLPYTVMHMTPEDVTYMRGSMKLNLVVLLTDLFNLFEI--------- 292
            ::.||::|:.|:..|.|::|.: ..|.:.||:.|...|:|.|.:|.:.:||..||:
Mouse   282 SLADSLYNLQLIQEFCQEYLNH-CCHFSLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPR 345

  Fly   293 -------HPAKCVCYPGMDGQVP---------------------------HSNSFGGGLNRRS-- 321
                   .|||.|      ..||                           || |..||:.|.|
Mouse   346 VVRPQGAEPAKDV------PSVPVLNAAKRNIRDSSSSSDFSSRYTRPQTHS-SASGGIRRSSSM 403

  Fly   322 --------TPPNEYQT-VQSNNFD-----GNHAEAFVVHK-------SRGIT---TLASMHSQQQ 362
                    |.|.|.:| |...:||     .:.|::...::       :.|:|   :.||.|.::.
Mouse   404 SYVDGFIGTWPKEKRTSVHGVSFDISFDKEDSAQSSTPNRGIIRSVSNEGLTLNNSRASKHIRKN 468

  Fly   363 QQLHQQQQHQQQYHQQPLQQHPSQSQLQIQQQEPLVPARLRQAKEKTN-------VESKA--DER 418
            .........:::..::.|...|..   .:|...||....| .:.|.|:       ::::.  ||.
Mouse   469 LSFKPVNGEEEESIEEELHVDPHG---DLQSPMPLNTNEL-NSNESTHYKLPNGALQNRVLLDEF 529

  Fly   419 GDFVAAGRPSNWE------QSRRPSFAGR--------------RSRRNSSSEDSQLTIENFGGSQ 463
            |:.:..  ||..|      .:.||....|              .|..||:.:.:|.:.:|...::
Mouse   530 GNQIET--PSIEEALQIIHDTERPPHTPRPDQIANGFFLHGQDLSILNSNIKLNQSSPDNLTDTK 592

  Fly   464 DQLNTLGRYERDRERKLSNTSVGSYPVEPAVAVRSSIADARGTLQLGYDTDSGSE-KQDRETEKY 527
            ..|:.:    .|.....:...|.|..:...:...||:.|.  |:.|..|.|..|: .||     |
Mouse   593 GALSPI----TDTTEVDTGIHVPSEDIPETMDEDSSLRDY--TVSLDSDMDDASKLLQD-----Y 646

  Fly   528 SMRRQVSVDNVPTVSSHNLSNAGSPLP--VARHKQHSSDKDYSSNSGMTPDAYNDSRSTSGYDPE 590
            .:|            :.|...|.||.|  ::...|..|....||...||..|....|..:..|.:
Mouse   647 DLR------------ASNPREALSPCPSTISTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGK 699

  Fly   591 STPVRKSSTSSMPASPAAWQLDV-----------------GDDDMRSLENASKLSTIRMKLEEKR 638
            |     |.:||...:|...:|::                 |.|..:.|  ||::..:||:|||||
Mouse   700 S-----SGSSSQKTTPEGSELNIPHVVSWAQIPEEAGVAPGRDTTQLL--ASEMVHLRMRLEEKR 757

  Fly   639 RRIEQDKRKIEMALLRHQEKEDLESCPDVMKWETMSNESKRTPDMDPVDLDKYQQSIAIMNMNLQ 703
            |.||..|:|:|.|..:.::|....:...|:|        |:...:.|:     ::..|    ..:
Mouse   758 RAIEAQKKKMEAAFTKQRQKMGRTAFLTVVK--------KKGEGISPL-----REEAA----GAE 805

  Fly   704 DIQQDIHRLATQQSQ-MQAQHLQAQQLMQAQQIANMLNQQQTYGSQQHLA-------DHHYQQQR 760
            |.:....|...::|| |..|        :::.:|::....:|...:...:       :..:....
Mouse   806 DEKVYTDRAKERESQKMDGQ--------RSKSLADIKESMETPPGRWLKSPTTPVDPERQWNLTS 862

  Fly   761 PMQQSFGSSPHLPQAYNAPVSAYSSRPPSRDPYQQQLHHQQQQPMPMPQPMQYVNEHGQYMSPPQ 825
            |.:::......|  .|...:...:|.........|:|..||:..|.|.:...:|      :||||
Mouse   863 PSEETLNEGEIL--EYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQAWV------ISPPQ 919

  Fly   826 PAHYMPQQAQQPQSIYSDNGAAYNHSNHSPYGGTPQYRSSVVYDDYGQPTNHFYLHESSPQPQAH 890
            |                                                         |||.|..
Mouse   920 P---------------------------------------------------------SPQKQIR 927

  Fly   891 QHPQRRTWAHSAAAAAYEQQQQIQPSLVDVNAWQTQQHQKQKQTWMNRPPSSAGAPSPGSFMLHQ 955
            ....|:....||||                                   |.|:.:|.|
Mouse   928 DFKPRQAGLSSAAA-----------------------------------PFSSDSPRP------- 950

  Fly   956 NGGGGGGGGGGGELQHLFQVQASPQHGQRQVSGSNGVQRQQSLTNLRDNRSPKAPQNMGMPMGMP 1020
                               ...|||...|: |.|..|:.|         |:|:..:....|:
Mouse   951 -------------------THPSPQSSTRK-SASFSVKNQ---------RTPRPNELKITPL--- 983

  Fly  1021 MQQEDMMAPQSICFIGDEEDVDELERNIIESMQSTHISDFVHQQQQQHQHQQQLQQQQRLQGHSG 1085
              ...:..|:|         ||.|.|
Mouse   984 --NRTLTPPRS---------VDSLPR--------------------------------------- 998

  Fly  1086 RGSSSEDYDSGEMISNKLNITSGNLTYRIPSPSRPSIQANSFQDPRAMAAASGGEDQPPEKGFYI 1150
                                      .|..|||:..||..||        ...|:|..|:
Mouse   999 --------------------------LRRFSPSQVPIQTRSF--------VCFGDDGEPQ----- 1024

  Fly  1151 SFDDEQPKRPKPPLRAKRSPKK--------ESPPGSRDSVDNQATLKRESLSHLHNNNNIGFGND 1207
                   |.||.....|:.|.:        :..||.::....::|:                  .
Mouse  1025 -------KEPKQKEEIKKEPSECKGTLGPCDHNPGEKEIKPVESTV------------------S 1064

  Fly  1208 DVNSKPVTRHSIHGLNNSNSVKSPGNATYNKYTDEPPIQLRQLAVSGAMSPTSNERHHLDDV--S 1270
            :|.|:|:| .::....|.:.:..|        |:.||        .....||:.:..:|.:|  |
Mouse  1065 EVLSQPIT-ETVCVTPNEDQLSQP--------TEPPP--------KPVFPPTAPKNVNLIEVSLS 1112

  Fly  1271 NQSPQQTQQPMSPTRLQQSSNNAEAAKNKALVIGADSTNLDPESVDEMERRKEKIMLLSLQRRQQ 1335
            :..|.: :..:|..:|...|:..:...::.:..|....: |.::.::|..::..::...|:|.::
Mouse  1113 DLKPPE-KADVSVEKLDGESDKEQFDDDQKVCCGFFFKD-DQKAENDMAMKRAALLEKRLRREKE 1175

  Fly  1336 QEEAKARKEIEASQKREKEREKEEERARKKEEQMARRAAILEQHRLKKAIEEAEREGKTLDRPDL 1400
            .:..|.:.|.|...|:|:.|.|.||..:|||::.|||..|.:::..:|
Mouse  1176 TQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRK----------------- 1223

  Fly  1401 HVKLQSHSSTSTTPRLRQQRTTRPRPKTIHVDDASVDISEASSISSRGKKGSS-SNLTGYGQLSS 1464
            .:||.....|...||.:..:..:.|||:||.|..     |:.....:|..||. |.:.....||.
Mouse  1224 QLKLMEDMDTVIKPRPQAAKQKKQRPKSIHRDHI-----ESPKTPIKGPPGSRISRVFSVSSLSL 1283

  Fly  1465 NSMKRDYYRGSQDSLTVKDSGLGRATPPRRAPSPGMGMGASGRHMPSPSGPGSLPPGLISKRRG- 1528
            .|:      .:.||.:|..   |:.||                  .|.|..|.|.|.....|.|
Mouse  1284 ASL------NTGDSESVHS---GKRTP------------------RSESVEGFLSPSRCGSRNGE 1321

  Fly  1529 --FDDGSSDFSLTPNLNMEYSGPKLYKQPAAKSNRGIILNAVEYCVFPGVVNREAKQKVLEKIAR 1591
              :::.|:..|:..  ..||:||||||:|:||||:.||.||:.:|...|.||...|:|:||::.:
Mouse  1322 KDWENASTTSSVAS--GTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEEMEK 1384

  Fly  1592 SEAKHFLVLFRDAGCQFRALYSYQPETDQVTKLYGTGPSQVEEVMFDKFFKYNSGGKCFSQVHTK 1656
            |:|.:||:||||:|||||:||:|.|||:::.||.|.||..:.:.|.:..:||||..|.||.:..|
Mouse  1385 SDANNFLILFRDSGCQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSDRKQFSHIPAK 1449

  Fly  1657 HLTVTIDAFTIHNSLWQGKRVQLPSK 1682
            .|:.::||.|||:.|||.||...|.|
Mouse  1450 TLSASVDAITIHSHLWQTKRPVTPKK 1475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Patronin	NP_001261051.1	CAMSAP_CH	189..272	CDD:432229	28/83 (34%)
		CAMSAP_CC1	612..679	CDD:465344	22/83 (27%)
		PRK10263	<741..>898	CDD:236669	22/163 (13%)
		tolA_full	1271..>1391	CDD:274303	26/119 (22%)
		CAMSAP_CKK	1548..1676	CDD:198119	65/127 (51%)
Camsap2	XP_006529895.1	CAMSAP_CH	237..315	CDD:432229	27/78 (35%)
		CAMSAP_CC1	733..789	CDD:465344	22/65 (34%)
		PHA03247	<917..1028	CDD:223021	46/337 (14%)
		CAMSAP_CKK	1341..1469	CDD:198119	65/127 (51%)