Protein Alignment Patronin and CAMSAP3

DIOPT Version :9

• Sequence 1: NP_001261051.1
• Gene: Patronin / 36978
• FlyBaseID: FBgn0263197
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_001073898.1
• Gene: CAMSAP3 / 57662
• HGNCID: 29307
• Length: 1276
• Species: Homo sapiens
• Alignment Length: 1839
• Identity: 397/1839 - (21%)
• Similarity: 616/1839 - (33%)
• Gaps: 751/1839 - (40%)

  Fly     3 VETQEIRQARQRASVKWLLSKAFN--NRVPDNLKEPFYRDHENQERLKPQIIVELGNATLYC--- 62
            ::..:..:|:..||:.|:|..||.  ..||..|.||||.|...||.:||.:...|.:|.|||
Human    24 LDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPFYTDQYAQEHVKPPVTRLLLSAELYCRAW 88

  Fly    63 -QTLANLYSDPNYQSMNHWSIIQTLARKGVPVAESADMPITETVLIQTNPLRINAHMSVIESLMV 126
             |.|..|.:.||..     :::..|||:|. |....:.|:.|..| :..|:.:.||::||::||.
Human    89 RQALPQLETPPNPS-----ALLALLARRGT-VPALPERPVREADL-RHQPILMGAHLAVIDALMA 146

  Fly   127 LYAKEISSGDRVMAAIRRISGNNYQAPTG-QSYEQALLGWISHACAALKKRIIKE---------- 180
            .:|.|.:         :.:.|     |.. .|.|..||.|:......|:::..:|
Human   147 AFAFEWT---------KTLPG-----PLALTSLEHKLLFWVDTTVRRLQEKTEQEAAQRASPAAP 197

  Fly   181 VDAGLP----------------------DDNGSR-------------LQTPDIPPVRDFQDLCDG 210
            .|...|                      .::||:             .:.|..|.|...|||..|
Human   198 ADGAAPAQPSCPTRWYWKLVPHAIAFCLKESGSKPPMIRYRKDRVVARRAPCFPTVTSLQDLASG 262

  Fly   211 ICLALLISYYCPKVVPWTSVRINYLPAVEDSIHNILLVCNFSQKHLPYTVMHMTPEDVTYMRGSM 275
            ..||..|..|||:::....|.:....:|.||::|:.||.:|....|| ....::.||:.|:...:
Human   263 AALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASRLP-RGCPLSLEDLLYVPPPL 326

  Fly   276 KLNLVVLLTDLFNLFEIHPAKCVCYPGM-DGQVPHSNSFGGGLNRRSTPPNEYQTVQSNNFDGNH 339
            |:||||:|.:||..||:.....|....: ||   |:.|..|   ..::||      |:|:  |:.
Human   327 KVNLVVMLAELFMCFEVLKPDFVQVKDLPDG---HAASPRG---TEASPP------QNNS--GSS 377

  Fly   340 AEAFVVHKS-----------RGIT-TLASMHSQQQQQLHQQQQHQQQYHQQPLQQHPS------- 385
            :..|.....           ||.| :|.|..|....:...:..::|.  .:||.|..|
Human   378 SPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQL--SRPLSQAVSFSTPFGL 440

  Fly   386 QSQLQIQQQEPLVPARLRQAKEKTNVESKADERGDFVAAGRPSNWEQSRRPSFAGRRSRRNSSSE 450
            .|.:.:...:|::   ||...            .|.:...||           |..|:......|
Human   441 DSDVDVVMGDPVL---LRSVS------------SDSLGPPRP-----------APARTPTQPPPE 479

  Fly   451 DSQL-TIENFGGSQDQLNTLGRYERDRERKL--SNTSVGSY-------PVEPAVAVRSSIADARG 505
            ...| |||      :.|..:    ...|.:|  ...:.||:       |.:|::|   |.....|
Human   480 PGDLPTIE------EALQII----HSAEPRLLPDGAADGSFYLHSPEGPSKPSLA---SPYLPEG 531

  Fly   506 TLQLGYDTDSGSEKQDRETEKYSMRRQVSVDNVPT------VSSHNLSNAGSPLPVARHKQHSSD 564
            |         .....||.|:...........:.|:      .|.....:.|||..||     ||.
Human   532 T---------SKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVA-----SSP 582

  Fly   565 KDYSSNSGMTPDAYNDSRSTSGYDPESTPVRKSSTSSMPASPAAWQLDVGDDDMRSLENASKLST 629
            ...:|...||..|....:....    .......|.:|.||.|.|.              :|::|.
Human   583 AATNSEVKMTSFAERKKQLVKA----EAEAGAGSPTSTPAPPEAL--------------SSEMSE 629

  Fly   630 IRMKLEEKRRRIEQDKRKIEMALLRHQ----------------------EKEDLESCPDVMKWET 672
            :..:||||||.||..||:||....:|:                      |.|:.:|.| |...|.
Human   630 LSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGP-VPGGER 693

  Fly   673 MSNESKR-----------TPDMDPV---DLDKYQQSIAIMNMNLQDIQQDIHRLATQQSQMQAQH 723
            .:.|.:.           :||:.||   .|.:|.::::.::..|..:|:|:.||..||.::.|.
Human   694 PAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAP- 757

  Fly   724 LQAQQLMQAQQIANMLNQQQTYGSQQHLADHHYQQQRPMQQSFGSSPHLPQAYNAPVSAYSSRPP 788
                                                             |:   ||.||
Human   758 -------------------------------------------------PE---APGSA------ 764

  Fly   789 SRDPYQQQLHHQQQQPMPMPQPMQYVNEHGQYMSPPQPAHYMPQQAQQPQSIYSDNGAAYNHSNH 853
                                              ||..|..:|.....|::
Human   765 ----------------------------------PPPAAWVIPGPTTGPKA-------------- 781

  Fly   854 SPYGGTPQYRSSVVYDDYGQPTNHFYLHESSPQPQAHQHPQRRTWAHSAAAAAYEQQQQIQPSLV 918
                                         :||.|
Human   782 -----------------------------ASPSP------------------------------- 786

  Fly   919 DVNAWQTQQHQKQKQTWMNRPPSSAGAPSPGSFMLHQNGGGGGGGGGGGELQHLFQVQASPQHGQ 983
                             ..|.|::..:|.||
Human   787 -----------------ARRVPATRRSPGPG---------------------------------- 800

  Fly   984 RQVSGSNGVQRQQSLTNLRDNRSPKAPQNMGMPMGMPMQQEDMMAPQSICFIGDEEDVDELERNI 1048
                               .::||::|::       ....|..:||.: ..:....|||.|
Human   801 -------------------PSQSPRSPKH-------TRPAELRLAPLT-RVLTPPHDVDSL---- 834

  Fly  1049 IESMQSTHISDFVHQQQQQHQHQQQLQQQQRLQGHSGRGSSSEDYDSGEMISNKLNITSGNLTYR 1113
                  .|:..|
Human   835 ------PHLRKF----------------------------------------------------- 840

  Fly  1114 IPSPSRPSIQANSFQDPRAMAAASGGEDQPPEKGFYISFDDEQPKRP---KPPLRAKRSPKKE-- 1173
              |||:..:|..|     ::..|   |:.|||         |...||   :.||.:...|..|
Human   841 --SPSQVPVQTRS-----SILLA---EETPPE---------EPAARPGLIEIPLGSLADPAAEDE 886

  Fly  1174 ---SPPGSRDSVDNQATLKRESLSHLHNNNNIGFGNDDVNSKPVTRHSIHGLNNSNSVKSPGNAT 1235
               ||.|:.||::.:|:.:.|.        .:|.|                             .
Human   887 GDGSPAGAEDSLEEEASSEGEP--------RVGLG-----------------------------F 914

  Fly  1236 YNKYTDEPPIQLRQLAVSGAMSPTSNERHHLDDVSNQSPQQTQQPMSPTRLQQSSNNAEAAKNKA 1300
            :.|..|:|.
Human   915 FYKDEDKPE-------------------------------------------------------- 923

  Fly  1301 LVIGADSTNLDPESVDEMERRKEKIMLLSLQRRQQQ-EEAKARK---EIEASQKREK-EREKEEE 1360
                           |||.:::..:    |:|:|:: |||:.||   |:|..|:||: .|..:||
Human   924 ---------------DEMAQKRASL----LERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEE 969

  Fly  1361 --------------------RARKKEEQMARRAAILEQHRLKKAIEEAEREGKTLDRPDLHVKLQ 1405
                                ||..:||...|:.....|        |.||..:.....||...|:
Human   970 APGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQ--------EYERRAQLKLMDDLDKVLR 1026

  Fly  1406 SHSSTSTTPRLRQQRTTRPRPKTIHVDDASVDISEASSISSRGKKGSS-SNLTGYGQLSSNSMKR 1469
            ..::.|..|....:|.||||...  .||:::..|.|     ||..||. |.:.....||.:::..
Human  1027 PRAAGSGGPGRGGRRATRPRSGC--CDDSALARSPA-----RGLLGSRLSKIYSQSTLSLSTVAN 1084

  Fly  1470 DYYRGSQDSLTVKDSGLGRATPPRRAPSPGMGMGASGRHMPSPSG-PGSLPPGLISKRRGFDDGS 1533
            :.:           :.||...|..|||||      ||  :.|||. ||       |:.|.:::||
Human  1085 EAH-----------NNLGVKRPTSRAPSP------SG--LMSPSRLPG-------SRERDWENGS 1123

  Fly  1534 SDFSLTPNLNMEYSGPKLYKQPAAKSNRGIILNAVEYCVFPGVVNREAKQKVLEKIARSEAKHFL 1598
            :  :.:|....||:||:|||:|:||||:.||.||:.:|...|.||...|.::||:|.:|:|.|||
Human  1124 N--ASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFL 1186

  Fly  1599 VLFRDAGCQFRALYSYQPETDQVTKLYGTGPSQVEEVMFDKFFKYNSGGKCFSQVHTKHLTVTID 1663
            :||||:.|||||||:...||:::::|.|.||..|...|.:..:||||..|.|:|:..|.:::::|
Human  1187 ILFRDSSCQFRALYTLSGETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVD 1251

  Fly  1664 AFTIHNSLWQGKRVQLPSK 1682
            ||||...|||||:...|.|
Human  1252 AFTIQGHLWQGKKPTTPKK 1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Patronin	NP_001261051.1	CAMSAP_CH	189..272	CDD:288798	28/95 (29%)
		CAMSAP_CC1	612..679	CDD:293700	22/88 (25%)
		tolA_full	1271..>1391	CDD:274303	27/144 (19%)
		CAMSAP_CKK	1549..1667	CDD:285846	56/117 (48%)
CAMSAP3	NP_001073898.1	CAMSAP_CH	244..323	CDD:288798	26/79 (33%)
		CAMSAP_CC1	613..670	CDD:293700	20/70 (29%)
		CAMSAP_CKK	1137..1255	CDD:285846	56/117 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150787
Domainoid	1	1.000	133	1.000	Domainoid score	I5067
eggNOG	1	0.900	-	-		E1_KOG3654
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47141
OrthoDB	1	1.010	-	-		D324856at33208
OrthoFinder	1	1.000	-	-		FOG0001093
OrthoInspector	1	1.000	-	-		otm41258
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21595
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3368
SonicParanoid	1	1.000	-	-		X931
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.940