Protein Alignment Patronin and camsap2b

DIOPT Version :10

• Sequence 1: NP_001261051.1
• Gene: Patronin / 36978
• FlyBaseID: FBgn0263197
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: XP_073785966.1
• Gene: camsap2b / 558673
• ZFINID: ZDB-GENE-070912-80
• Length: 1429
• Species: Danio rerio
• Alignment Length: 1850
• Identity: 395/1850 - (21%)
• Similarity: 665/1850 - (35%)
• Gaps: 631/1850 - (34%)

  Fly     7 EIRQARQRASVKWLLSKAF-NNRVPDNLKEPFYRDHENQERLKPQIIVELGNATLYCQT-LANLY 69
            :..:|:...|:.||::||| ::.||..|::|||||..:||.:||.::..|.:|.|||:. ...|.
Zfish    35 DFSRAKISCSLTWLIAKAFGSDCVPVELEDPFYRDQYDQEHVKPPVVSLLLSAELYCRAGSLILR 99

  Fly    70 SDPNYQSMNHWSIIQTLARKGVPVAESADMPITETVLIQTNPLRINAHMSVIESLMVLYAKEISS 134
            ||.....:.|.::||.||:|.:.|.:...: :||..|.:| |:::::|:::|::||:.|..|:.|
Zfish   100 SDAAKPLLGHNAVIQALAQKALYVTDQERL-VTERDLCKT-PIQMSSHLAMIDTLMMAYTVEMVS 162

  Fly   135 GDRVMAAIRRISGNNYQAPTGQSYEQALLGWISHACAALKKRIIKE-----------VDAGLPDD 188
            .:||::.|::.:....:.......|:|:..||:.....|::.:.:|           |..|....
Zfish   163 VERVLSCIQKFTPFLPEEDFPYDAEEAVTTWINKVNEHLRELLTQEQRGPDIGETCAVQKGRYRK 227

  Fly   189 NGSRLQTPDIPPVRD--FQDLCDGICLALLISYYCPKVVPWTSVRINYLPAVEDSIHNILLVCNF 251
            :.|::::....|:.|  .:|..||..|..|:.:|||..||...|.|....::.||::|:.|:..|
Zfish   228 DDSKIRSALCVPLVDSLMKDNTDGCALGALLHFYCPDAVPLEDVCIKETMSLADSLYNLQLIQEF 292

  Fly   252 SQKHLPYTVMHMTPEDVTYMRGSMKLNLVVLLTDLFNLFE-IHPA----KCVCYPGMDGQVPHSN 311
            .:::| ....|.|.||:.|...::|.|.:|.:.:||...| :.|:    :.|.....|..  .||
Zfish   293 CRENL-NNCCHFTLEDMLYASSTIKSNYLVFMAELFWWCEVVKPSFVQPRTVNTKASDSS--QSN 354

  Fly   312 SF------------GGGLNRRSTPPNEYQTV--QSNNF---DG------------NHAEAF---- 343
            ..            |.....||.|.|:...|  :|::.   ||            .|..:|
Zfish   355 KMAPITKQNLIHRPGSPEQSRSQPNNDSSAVIRRSSSMSYVDGCVGTWPKEKRSSAHGISFEIPL 419

  Fly   344 ------------------------VVHKSRGI---TTLASMHSQQQQQLHQQQQHQQQYHQQPLQ 381
                                    |.|.:||:   .:...::.....::|::.....   .:|:.
Zfish   420 DDRTSSSSGRGLSRSVSTEGLGFKVHHAARGMRRNLSFQPVNGNAHSKIHEEDGEDS---NRPIS 481

  Fly   382 QH----------------PSQSQLQIQQQEPLVPARLR----QAKEKTNVESKADERGDFV---- 422
            :|                || .....|...|.:...|:    ..:.::::...:.:...|:
Zfish   482 RHRLGTYTGYTNGVSTGNPS-PPYDAQPSTPSIEEALKIIHDSERPQSSLPPPSGDSAFFLHNPS 545

  Fly   423 ---AAGRPSNWEQSRRPSFAGRRSRRNSSSEDSQLTI----ENFGGSQDQLNTLGRY---ERDRE 477
               :|..|:..|.|...:.|. .:..||:|.|....|    |:....||:.::|..|   ::|.|
Zfish   546 SSNSASDPNEPEDSLNKARAD-DADLNSTSTDMDTGIHVRTEDIQDGQDEDSSLKDYSDMDQDYE 609

  Fly   478 RK---LSNTSVGSYPVEPAVAVRSSIADARGTLQLGYDTDSGSEKQDRETEKYSMRRQVSVDNVP 539
            .:   |.:||  ..|....:..||.......:|.......|.:|::.|:......|...|..|.|
Zfish   610 ARSCPLPDTS--GNPCPSLLGTRSLATSMASSLGSAIRMTSFAEQKFRKLNHGDGRSSGSGGNTP 672

  Fly   540 TVSSHNLSNAGSPLPVARHKQHSSDKDYSSNSGMTPDAYNDSRSTSGYDPESTPVRKSSTSSMPA 604
            ..:..|.:..|:               |.:...:|||.::.:|.||..||
Zfish   673 ETAELNATTPGA---------------YGTVRSVTPDTHSPARITSPRDP--------------- 707

  Fly   605 SPAAWQLDVGDDDMRSLENASKLSTIRMKLEEKRRRIEQDKRKIEMALLRHQE------------ 657
                           |...||::..::||||||||.||..|:|:|.|..||::
Zfish   708 ---------------SHLLASEMVQLKMKLEEKRRAIEAQKKKVEAAFTRHRQRMGRTAFLNVVR 757

  Fly   658 -----------------KEDLESCPDVMKWETMSNES-----KRTPDMDP-----------VDLD 689
                             :|...:.|:..|.....|:|     :..||..|           |||.
Zfish   758 RKGVVSPLGGSSEGPDGREKTTNDPEPQKSPLTLNDSNARLERCRPDGAPPKSPLEDAGVEVDLT 822

  Fly   690 KYQQSIAIMNMNLQDIQQDIHRLATQQSQMQAQHLQAQQLMQAQQIANMLNQQQTYGSQQHLADH 754
            :|.:||..:|.:|..:|.::.|||.||          :::||
Zfish   823 EYTRSIERLNTSLGFLQSEMQRLAQQQ----------ERIMQ----------------------- 854

  Fly   755 HYQQQRPMQQSFGSSPHLPQAYNAPVSAYSSRPPSRDPYQQQLHHQQQQPMPMPQPMQYVNEHGQ 819
                                                                       :.||..
Zfish   855 -----------------------------------------------------------MREHQS 860

  Fly   820 Y-MSPPQPAHYMPQQAQQPQSIYSDNGAAYNHSNHSPYGGTPQYRSSVVYDDYGQPTNHFYLHES 883
            : :|||.|                           ||.....:.|||.|.
Zfish   861 WVISPPDP---------------------------SPRKQFRELRSSSVV--------------- 883

  Fly   884 SPQPQAHQHPQRRTWAHSAAAAAYEQQQQIQPSLVDVNAWQTQQHQKQKQTWMNRPPSSAGAPSP 948
                                                                             
Zfish   884 ----------------------------------------------------------------- 883

  Fly   949 GSFMLHQNGGGGGGGGGGGELQHLFQVQASPQHGQRQVSGSNGVQRQQSLTNLRDNRSPKAPQNM 1013
                         |.|..|.|..:.....||:...|..|   .::|:.:..:.|..|:|: |.::
Zfish   884 -------------GRGSVGSLSPILSSTGSPRTTHRSPS---TIKRKSASFHARTPRTPR-PNDL 931

  Fly  1014 GMPMGMPMQQEDMMAPQSICFIGDEEDVDELERNIIESMQSTHISDFVHQQQQQHQHQQQLQQQQ 1078
            .:.....|    :..|||         ||.|.|
Zfish   932 KVTSFSRM----LNTPQS---------VDSLPR-------------------------------- 951

  Fly  1079 RLQGHSGRGSSSEDYDSGEMISNKLNITSGNLTYRIPSPSRPSIQANSF--QDPRAMAAASGGED 1141
                                             .|...||:|.|.:.::  .|.||::
Zfish   952 ---------------------------------LRRVLPSQPQISSFAYLGSDERALS------- 976

  Fly  1142 QPPEKGFYISFDDEQPKRPKPPLRAKRSPKKESPPGSRDSVDNQATLKRESLSHLHNNNNIGFGN 1206
                        .||..:.||           ..|.|:|:..:|       :|........|.|.
Zfish   977 ------------KEQSDKEKP-----------CKPESKDTAADQ-------MSEKQKEEKRGAGE 1011

  Fly  1207 DDVNSKPVTRHSIHGLNNSNSVKSPGNATYNKYTDEPPIQLRQLAVSGAMSPTSNERHHLDDVSN 1271
            .|..:|.:|          :.|.:.||.  |:...|....|.::.:| .:.|       ||....
Zfish  1012 SDKLTKALT----------SEVTASGNT--NEEESEESKDLIEVPLS-VLKP-------LDGHEL 1056

  Fly  1272 QSPQQTQQPMSPTRLQQSSNNAEAAKNKALVIGADSTNLDPESVDEMERRKEKIMLLSLQRRQQQ 1336
            :|.::|:..:.            :..::.:..|....: |.:..:::.::|..:|...|:|.::.
Zfish  1057 ESSRETETGLG------------SKPDQKMCCGFFYKD-DLQGEEDIAQKKAALMEKRLRREKEM 1108

  Fly  1337 EEAKARKEIEASQKREKEREKEEERARKKEEQMARRAAILEQHRLKKAIEEAEREGKTLDRPDLH 1401
            :..|.::|.|..||:|..|.|.||..:|||::.|||..|..:|..:|                 .
Zfish  1109 QIKKQQQEAEIEQKKEAARMKVEEERQKKEDEKARREYIKHEHMRRK-----------------Q 1156

  Fly  1402 VKLQSHSSTSTTPRLRQQRTTRPRPKTIHVDDASVDISE--------ASSISSRGKKGSSSNLTG 1458
            :||.....:...|.....:..:||||::|     .||.|        |:....||...||.:|..
Zfish  1157 LKLMEDMDSVIKPSPSGAKQKKPRPKSMH-----RDIMESPKPPARTATGSRPRGYSVSSISLAS 1216

  Fly  1459 YGQLSSNSMKRDYYRGSQDSLTVKDSGLGRATPPRRAPSPGMGMGASGRHMPSPSGPGSLPPGLI 1523
            .....:.|::.|........|:........::|..|...|   ..|.|...|.||..|:
Zfish  1217 LNLADNESIQSDKRTSRGSRLSPGSLCFFLSSPKGRKGRP---ESAEGFLSPCPSVSGN------ 1272

  Fly  1524 SKRRGFDDGSSDFSLTPNLNMEYSGPKLYKQPAAKSNRGIILNAVEYCVFPGVVNREAKQKVLEK 1588
            .:....:..||..|     |.||:||||||:|:||||:.||.||:.:|...|.||...|.|:||:
Zfish  1273 GENWELESTSSAAS-----NTEYTGPKLYKEPSAKSNKYIIQNALAHCCLAGRVNEGQKNKILEE 1332

  Fly  1589 IARSEAKHFLVLFRDAGCQFRALYSYQPETDQVTKLYGTGPSQVEEVMFDKFFKYNSGGKCFSQV 1653
            :.::||.:||:||||.|||||:||:|.||.:::.||.|.||..:...|.:..:||:|..|.||::
Zfish  1333 MEKTEANNFLILFRDTGCQFRSLYTYYPEAEEMNKLAGIGPKTITPKMIENLYKYSSDKKQFSKI 1397

  Fly  1654 HTKHLTVTIDAFTIHNSLWQGKRVQLPSKK 1683
            ..|.::.::||.||::.|||.|: |..:||
Zfish  1398 PAKTMSASVDAITIYSHLWQNKK-QNTAKK 1426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Patronin	NP_001261051.1	CAMSAP_CH	189..272	CDD:432229	26/84 (31%)
		CAMSAP_CC1	612..679	CDD:465344	24/100 (24%)
		PRK10263	<741..>898	CDD:236669	12/157 (8%)
		tolA_full	1271..>1391	CDD:274303	27/119 (23%)
		CAMSAP_CKK	1548..1676	CDD:198119	61/127 (48%)
camsap2b	XP_073785966.1	None