DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patronin and camsap1a

DIOPT Version :9

Sequence 1:	NP_001261051.1	Gene:	Patronin / 36978	FlyBaseID:	FBgn0263197	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	XP_005161026.1	Gene:	camsap1a / 402833	ZFINID:	ZDB-GENE-060518-4	Length:	1461	Species:	Danio rerio

Alignment Length:	1959	Identity:	414/1959 - (21%)
Similarity:	670/1959 - (34%)	Gaps:	803/1959 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VETQEIRQARQRASVKWLLSKAF-NNRVPDNLKEPFYRDHENQERLKPQIIVELGNATLYCQTLA 66
            :|..:..:|:..|:::||.:||: ...:|::|::|||.|....|.:||.::..|.::.|||:...
Zfish    28 LEMYDSARAKIEANLRWLFAKAYGEEHIPEDLRDPFYTDQYCVEHIKPPVLCLLLSSELYCRVCG 92

  Fly    67 NLYSDPNYQSM-NHWSIIQTLARKGVPVAESADMPITETVLIQTNPLRINAHMSVIESLMVLYAK 130
            .|.......:: :|.:::|||||:|:.|.|..|.|:|...|..| |::::||:.:|::||:.|..
Zfish    93 LLLKGDQASALSSHQAVLQTLARRGISVREPDDTPVTHDDLTST-PIKMSAHIPLIDALMMAYTV 156

  Fly   131 EISSGDRVMAAIRRISGNNYQAPTGQSYEQALLGWISHACAALKKRII--KEVDAGLPDDNGSRL 193
            |:...:||:|:::|.|............|.|.|.||:.  ..||.|.:  ||:....|..:....
Zfish   157 EMMPIERVVASVKRFSTFCASKELPFDMEDAALFWINK--VVLKTRDLSEKELKVKQPLMDSPCH 219

  Fly   194 QTPD---------IPPV---------RD----------------FQDLCDGICLALLISYYCPKV 224
            |.||         :.||         |:                .:|:|||..|..:|.:|||:.
Zfish   220 QKPDLMNALAHCMLEPVEFSRVVRYRREHMSGHPVPHLAVMEDLMKDICDGAALLAVIHFYCPEY 284

  Fly   225 VPWTSVRINYLPAVEDSIHNILLVCNFSQKHLPYTVMHMTPEDVTYMRGSMKLNLVVLLTDLF-- 287
            :....:.:..:|::.||::||.|:..||.::| ....::..||:.|....:|.|::|.:.:||
Zfish   285 MRLDDICLKEVPSLSDSVYNIHLLREFSNEYL-NRCFYLHTEDLLYGPPVLKNNVMVFIAELFWW 348

  Fly   288 ------------NLFEIHPAKCVCYPGMDGQ-VPHSNSFGGGLNRRS--TP-PNEYQTVQSNNFD 336
                        :|.|:...:....|..... :|.||:     .:||  || |:......:...|
Zfish   349 FEVVKPDFVKPRDLQEVKDVRASLQPKSSRPLLPISNA-----TKRSFLTPSPSADSLATAAAPD 408

  Fly   337 GNHAEAFVVH--KSRGITTLASMHS---------QQQQ--------------------------- 363
            |  ...:.:|  :|..:|..:..||         |:||
Zfish   409 G--CMRYYLHPEESLSVTNRSPTHSPFHPLLPLRQRQQKPTQGDEISELRNRSNSLSRMDGLGLG 471

  Fly   364 ---QLHQQQQHQQQYHQ---------------------------------------QPLQQHPSQ 386
               ||....:.|:...|                                       |||   |..
Zfish   472 LGSQLSWTDRKQRPISQMEMDWERVCGDNISLARSISKDSLASNVISITPRHRINGQPL---PQT 533

  Fly   387 SQLQIQQQ------------------------EPLVPARLRQAKEKTNVESKADERGDFVAAGRP 427
            .|...|::                        |||.||.||..|||..: ||.:|.|:    ||.
Zfish   534 RQCDNQEEDEEEELLAVINPEGAAASRDGFFLEPLQPAVLRPNKEKAGI-SKREESGE----GRG 593

  Fly   428 SNWEQSRRPSFAGRRSRRNSSSEDSQLTIENFG---GSQDQLNTLGRYERDRERKLSNTSVGSYP 489
            ...| .|..|..||...|..:...::.|.....   .|.||       |..||:     |.||:.
Zfish   594 QGHE-GRSHSSDGRSQGRKGAYTPTECTFNRTFTPISSTDQ-------ESSREQ-----SPGSFF 645

  Fly   490 V-EPAVAVRSS--------IADAR------------------------GTLQLGYDTDSGSEK-- 519
            : ..|...|.|        |:|:.                        |...:|:..:..|.|
Zfish   646 LHSDAECARDSPLGGWEDVISDSEFEEDDDIQDVPEQELSKALLMMHAGKKCMGFGEEEESVKLC 710

  Fly   520 -----QDRETEKYSMRRQVSVDNVPTVSSHNLSNAGSPLPVARHKQHS---SDKDYSSNSGM--T 574
                 ::|:.::.:..|.....:|.:.:|...:..|.....|..::|.   .|..||:.|..  |
Zfish   711 EDVCIRERDDKEGASGRASPCPSVMSQASSTSTGTGRMTSFAERRRHRVGFPDGCYSTGSSQTTT 775

  Fly   575 PDAYNDSRSTSGYDPESTPVRKSSTSSMPASPAAWQLDVGDDDMRSLENASKLSTIRMKLEEKRR 639
            ||.     |.|.:.|         ..:.|.:|:...:           .||:|..:||:||||||
Zfish   776 PDG-----SESLHFP---------ADASPGTPSGRPV-----------VASELVHLRMQLEEKRR 815

  Fly   640 RIEQDKRKIEMALLR-----------------------HQEKEDL----------ESCPDVMKWE 671
            .||..|:::|....|                       |..|.::          ::|.:::|..
Zfish   816 AIELQKKRMENLSARQRLQLGKAAFLHVVKKGRSDTLPHPLKTEITFKEKPIAKDDTCVEILKPR 880

  Fly   672 TMSNESKRTPD--------------MDPV----DLDKYQQSIAIMNMNLQDIQQDIHRLATQQSQ 718
            ...:|.|.||.              :|.|    ||.:..:||.::|..:..|||.:.:|:.||..
Zfish   881 RKDSECKETPSEEDKDNRVAAGGGALDEVGGEPDLSECSRSIELLNEAIGAIQQQMMQLSFQQDL 945

  Fly   719 MQAQHLQAQQ---LMQAQQIANMLNQQQTYGSQQHLADHHYQQQRPMQQSFGSSPHLPQAYNAPV 780
            :..|.:|..|   |.:...:..:                  .:|.|..:|     .|...:...:
Zfish   946 LMKQTVQPPQEPSLTKPNTVTPL------------------NEQHPETKS-----RLSVQFTETL 987

  Fly   781 SAYSSRPP----SRDPYQQQLHHQQQQPMPMPQPMQYVNEHGQYMSPPQPAHYMPQQAQQPQSIY 841
            |..:.|||    ||.|..
Zfish   988 STATKRPPRLSSSRTPRT----------------------------------------------- 1005

  Fly   842 SDNGAAYNHSNHSPYGGTPQYRSSVVYDDYGQPTNHFYLHESSPQPQAHQHPQRRTWAHSAAAAA 906
                                           :||:.....|::|:|
Zfish  1006 -------------------------------KPTDLKLSKEANPRP------------------- 1020

  Fly   907 YEQQQQIQPSLVDVNAWQTQQHQKQKQTWMNRPPSSAGAPSPGSFMLHQNGGGGGGGGGGGELQH 971
                                               :|.|.:||
Zfish  1021 -----------------------------------AAKASTPG---------------------- 1028

  Fly   972 LFQVQASPQHGQRQVSGSNGVQRQQSLTNLRDNRSPKAPQNMGMPMGMPMQQEDMMAPQSICFIG 1036
                                            .|:|:|..
Zfish  1029 --------------------------------GRTPRAET------------------------- 1036

  Fly  1037 DEEDVDELERNIIESMQSTHISDFVHQQQQQHQHQQQLQQQQRLQGHSGRGSSSEDYDSGEMISN 1101
            :||.|.:                                       ..|||
Zfish  1037 EEEGVAK---------------------------------------EGGRG-------------- 1048

  Fly  1102 KLNITSGNLTYRI-PSPSRPSIQANSFQDPRAMAAASGGEDQPPEKGFYISFDDEQPKRPKPPLR 1165
             |.....|.|:|: .|.:|   :|:|.:
Zfish  1049 -LKGIIRNTTFRLQESANR---RADSLE------------------------------------- 1072

  Fly  1166 AKRSPKKESPPGSRDSVDNQATLKRESLSHLHNNNNIGFGNDDVNSKPVTRHSIHGLNNSNSVKS 1230
               ||:.|.||.....||  ||.:|        :.:.|.|.::|   ||:       ::.|..|:
Zfish  1073 ---SPQTELPPVEATLVD--ATRER--------SESGGSGKENV---PVS-------SDENKTKA 1114

  Fly  1231 PGNATYNKYTDEPPIQLRQLAVSGAMSPTSNERHHLDDVSNQSPQQTQQPMSPTRLQQSSNNAEA 1295
                           ||.::.:|....|:..|                    |...|:|.
Zfish  1115 ---------------QLIEVDMSDLAEPSGTE--------------------PDGEQKSG----- 1139

  Fly  1296 AKNKALVIGADSTNLDPESVDEMERRKEKIMLLSLQRRQQQEEAKARK---EIEASQKREKEREK 1357
                   :|....: |.::.||:.:::...:   |:::::.|||:.||   |.|:..||::.|.|
Zfish  1140 -------LGFFFKD-DQKAEDELAKKRAAFL---LKQQRKAEEARIRKQQLEAESELKRDEARRK 1193

  Fly  1358 EEERARKKEEQMARRAAILEQHRLKKAIEEAEREGKTLDRPDLHVKLQSHSSTSTTPRLRQQRTT 1422
            .||...:|||:.|||..|.:::..:|..|..|.:|....||                     |..
Zfish  1194 AEEDRVRKEEEKARRELIKQEYLRRKQQELLEEQGAAKPRP---------------------RNR 1237

  Fly  1423 RPRPKTIHVDDAS----VDISEASSISSRGKKGSSSNLTGYGQLSSNSMKRDYYRGSQDSLTVKD 1483
            |||||::|..::|    |.:..|.|       |||.:|.                   .:.|..|
Zfish  1238 RPRPKSLHRAESSCSAPVSLCSAPS-------GSSLSLA-------------------SAATEGD 1276

  Fly  1484 SGLGRATPPRRAPS----PGMGMGASGRHMPSPSGPGSLPPGLISKRRGFDDGSSDFSLTPNLNM 1544
            |.........|..|    |.:...|| |:|                .|.:|:||:..|:|.  ..
Zfish  1277 SVASGGASSHRGESVESFPILSRNAS-RNM----------------ERDWDNGSTASSITS--VA 1322

  Fly  1545 EYSGPKLYKQPAAKSNRGIILNAVEYCVFPGVVNREAKQKVLEKIARSEAKHFLVLFRDAGCQFR 1609
            ||:||:|:|:|:||||:.||.||:.:|...|.||...|..:|::|.|.|:.|.::||||.|||||
Zfish  1323 EYNGPRLFKEPSAKSNKPIIQNAIAHCCLAGKVNEAQKNAILDEIERCESNHLIILFRDGGCQFR 1387

  Fly  1610 ALYSYQPETDQVTKLYGTGPSQVEEVMFDKFFKYNSGGKCFSQVHTKHLTVTIDAFTIHNSLWQG 1674
            |||.|.|||:::.||.||||..:...|.|:.:||:|..|.|:.:..|.::|::||.|||:.|||.
Zfish  1388 ALYIYSPETEEIIKLKGTGPRAISRKMIDRLYKYSSDRKQFTVIPAKSVSVSVDALTIHSHLWQA 1452

  Fly  1675 KRVQLPSKK 1683
            ||.....:|
Zfish  1453 KRPSTSKRK 1461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patronin	NP_001261051.1	CAMSAP_CH	189..272	CDD:288798	27/116 (23%)
		CAMSAP_CC1	612..679	CDD:293700	21/99 (21%)
		tolA_full	1271..>1391	CDD:274303	31/122 (25%)
		CAMSAP_CKK	1549..1667	CDD:285846	55/117 (47%)
camsap1a	XP_005161026.1	CAMSAP_CH	248..331	CDD:288798	21/83 (25%)
		CAMSAP_CC1	792..846	CDD:293700	17/64 (27%)
		DUF4200	1145..1226	CDD:290574	26/84 (31%)
		CAMSAP_CKK	1326..1454	CDD:198119	62/127 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585322
Domainoid	1	1.000	133	1.000	Domainoid score	I5007
eggNOG	1	0.900	-	-		E1_KOG3654
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1912
OMA	1	1.010	-	-		QHG47141
OrthoDB	1	1.010	-	-		D324856at33208
OrthoFinder	1	1.000	-	-		FOG0001093
OrthoInspector	1	1.000	-	-		otm25122
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21595
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X931
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.960