Protein Alignment Patronin and ptrn-1

DIOPT Version :10

• Sequence 1: NP_001261051.1
• Gene: Patronin / 36978
• FlyBaseID: FBgn0263197
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_001294846.1
• Gene: ptrn-1 / 181743
• WormBaseID: WBGene00004121
• Length: 1112
• Species: Caenorhabditis elegans
• Alignment Length: 1719
• Identity: 340/1719 - (19%)
• Similarity: 565/1719 - (32%)
• Gaps: 672/1719 - (39%)

  Fly     3 VETQEIRQARQRASVKWLLSKAFNNR--VPDNLKEPFYRDHENQERLKPQIIVELGNATLYCQTL 65
            :|..:..:.:..||::||:|:.:..:  :||.|::...||.....::...::..|.|.:||.|..
 Worm    11 IEDYDENEGKLAASIRWLISRVYEEKRDMPDKLRDGVQRDENGHFQIDEAVVGALCNGSLYAQAA 75

  Fly    66 ANLYSDPNYQSMNHWSIIQTLARKGVPVAESADMPITETVLIQTNPLRINAHMSVIESLMVLYAK 130
            |.::.:....:..|.:::..|...|:.|....:..:.|..|:.:.|..::||:::|::||:.:.:
 Worm    76 AKIFKESALVTKGHGAVLAVLTDYGIDVLHDGNELVEEAQLVASAPFNMSAHLAIIDALMMAHLR 140

  Fly   131 EISSGDRVMAAIRRISGNNYQAPTGQSYE--QALLGWISHACAALKKRIIKEVDAGLPDDNGSRL 193
            ::....||:.|:.|   :....|:.:..:  .|||.||:..|..::..:.:|      |.|
 Worm   141 DVIPVSRVVEAVSR---HTAVEPSEKPIDSVDALLFWINKICLLVRDDVERE------DSN---- 192

  Fly   194 QTPDIPPVRD-FQDLCDGICLALLISYYCPKVVPWTSVRINYLPAVEDSIHNILLVCNFSQKHLP 257
              .:||.:.| ::|:.||.||..|:.:|.|..:|...:..|......|..:|::|:..|.:.||.
 Worm   193 --TNIPEMEDLYEDISDGQCLCALLHWYRPHEMPVADISFNDSATTRDCQYNLMLLQLFCRHHLA 255

  Fly   258 YTVMHMTPEDVTYMRGSMKLNLVVLLTDLFNLFEIHPAKCVCYPGMDGQVPHSNSFGGGLNRRST 322
            ....|...||:.|:|.|:::|:...|.|||..||
 Worm   256 VDPFHFEIEDLLYLRDSLQMNVNAFLADLFVQFE------------------------------- 289

  Fly   323 PPNEYQTVQSNNFDGNHAEAFVVHKSRGITTLASMHSQQQQQLHQQQQHQQQYHQQPLQQH---P 384
            ||...:.|::... |.....||  .:..|..|.:.::..:..:|.:.: .:.|:..|...|   |
 Worm   290 PPVTPEPVETPRI-GPSPRRFV--PASAIPDLRAANAAARSSMHNRNR-PRMYNPPPAVSHSQGP 350

  Fly   385 SQSQLQIQQQEPLVPARLRQAKEKTNVESKADERGDFVAAGRPSNWEQSRRPSFAGRRSRRNSSS 449
            |:|..::.|                          |.:...||::....||
 Worm   351 SRSVSRMSQ--------------------------DSLFYSRPASIALQRR-------------- 375

  Fly   450 EDSQLTIENFGGSQDQLNTLGRYERDRERKLSNTSVGSYPVEPAVAVRSSIADARGTLQLGYDTD 514
                        |.||                                .|:.|.: |::.|::..
 Worm   376 ------------SMDQ--------------------------------DSVTDFQ-TIRQGFENQ 395

  Fly   515 SGSEKQDRETEKYSMRRQVSVDNVPTVSSHNLSNAGSPLPVARHKQHSSDKDYSSNSGMTPDAYN 579
            :|:.:.:|
 Worm   396 AGTAQLNR--------------------------------------------------------- 403

  Fly   580 DSRSTSGYDPESTPVRKSSTSSMPASPAAWQLDVGDDDMRSLENASKLSTIRMKLEEKRRRIEQD 644
                   ||                                   .|..:::|:.:|||||:  .|
 Worm   404 -------YD-----------------------------------GSVTASVRLAMEEKRRK--HD 424

  Fly   645 KRKIEMALLRHQEKEDLESCPDVMKWETMSNESKRTPDMDPVDLDKYQQSIAIMNMNLQDIQQDI 709
            ::..:|:.                   :.:||::|        |:|.:.:...:..|..|
 Worm   425 QQMAQMSF-------------------SSANETER--------LEKSKAAFFALRKNDND----- 457

  Fly   710 HRLATQQSQMQAQHLQAQQLMQAQQIANMLNQQQTYGSQQHLADHHYQQQRPMQQSFGSSPHLPQ 774
                                             ||...::...||...:.|.::...|    |.:
 Worm   458 ---------------------------------QTSKGKEEWYDHFEAKLRALELRVG----LEE 485

  Fly   775 AYNAPVSAYSSRPPSRDPYQQ--QLHHQQQQPMPMPQPMQYVNEHGQYMSPPQPAH--YMPQQAQ 835
            ..:...||..:|..|:....|  |.:......:||....|...   .|:..||..|  ||.||.|
 Worm   486 GEDGTQSARLNRASSQPSVVQAGQTYPANYMTLPMNAAAQMTQ---SYIQHPQTPHDYYMQQQMQ 547

  Fly   836 QPQSIYSDNGAAYNHSNHSPYGGTPQYRSSVVYDDYGQPTNHFYLHESSPQPQAHQHPQRRTWAH 900
            |.|     ...|...||   |....|.|:|:   ..|...:..|:.:|       .:|
 Worm   548 QQQ-----QQQAQAQSN---YASPSQLRNSL---SNGMINHAGYIVQS-------MYP------- 587

  Fly   901 SAAAAAYEQQQQIQPSLVDVNAWQTQQHQKQKQTWMNRPPSSAGAPSP-GSFMLH-------QNG 957
                ..|:||||           |.|..|.|      .|....||.:| |.|:.|       |.|
 Worm   588 ----GDYQQQQQ-----------QMQMQQGQ------MPVQPVGAYTPEGYFIPHHMQPIPVQQG 631

  Fly   958 ------GGGGGGGGGGELQHLFQVQASP-QHGQRQVSGSNGVQRQQSLTNLRDNRSPKAPQNMGM 1015
                  .|.|..|.....|..|.::.|| |.|..|.:                        |..:
 Worm   632 YQQMPQPGMGFNGMPATSQPGFNMEGSPAQMGYIQTA------------------------NKPL 672

  Fly  1016 PMGMPMQQEDMMAPQSICFIGDEEDVDELERNIIESMQSTHISDFVHQQQQQHQHQQQLQQQQRL 1080
            .|.|||||                                       |..||...|.....|...
 Worm   673 DMEMPMQQ---------------------------------------QPPQQPPQQMLPPNQNAF 698

  Fly  1081 QGHSGRGSSSEDYDSGEMISNKLNITSGNLTYRIPSPSRPSIQANSFQDPRAMAAASGGEDQPPE 1145
            ..||....:::......:..|: |:|:..:||:
 Worm   699 HLHSKSDDATQVQADPPLEINR-NLTNWGMTYK-------------------------------- 730

  Fly  1146 KGFYISFDDEQPKRPKPPLRAKRSPKKESPPGSRDSVDNQATLKRESLSHLHNNNNIGFGNDDVN 1210
                    .|.|.|..|               ||.:..|:..:|.| |..:::..::....|:..
 Worm   731 --------QEMPARSIP---------------SRRTWQNETFIKNE-LDLVNSKESVPHITDETT 771

  Fly  1211 SKP---VTRHSIHGLNNSNSVKSPGNATYNKYTDEPPIQLRQLAVSGAMSPTSNERHHLDDVSNQ 1272
            ::|   ..|.....|:|.:...:||.. :::..|...:.      :|..|         ||....
 Worm   772 TQPEEAARRFPDLMLDNHSENLAPGRG-FSRQNDRDDLS------TGRKS---------DDSPTD 820

  Fly  1273 SPQQT--QQPMSPTRLQQSSNNAEAAKNKALVIGADSTNLDPESVDEMERRKEKIMLLSLQRRQQ 1335
            :|.:|  ....|...:::.:|....||..||:.             :..:|||:|
 Worm   821 TPGRTFDDDEGSGENMEKIANERRIAKKAALIA-------------KTMKRKEEI---------- 862

  Fly  1336 QEEAKA-RKEIEASQKREKEREKEEERARKKEEQMARRAAILEQHRLKKAIEE--AEREGKTLDR 1397
              |.|. ..|...:::|:.|.||:|...|||.|:..:|..||::::.||..:|  ||...::..|
 Worm   863 --ETKVDLAEQRNAERRQVENEKKELALRKKVEKEQQRQKILDEYKRKKLEKELGAELSARSTGR 925

  Fly  1398 -----PDLHVKLQ----SHSSTSTTPRLRQQRTTRPRPKTIHVDDASVDISEASSISSRGKKGSS 1453
                 |.:..|.|    :.||...|||:|.|                      ||:..|
 Worm   926 GHSQPPFIRTKSQMSEVTESSRQNTPRMRGQ----------------------SSVEQR------ 962

  Fly  1454 SNLTGYGQLSSNSMKRDYYRGSQDSLTVKDSGLGRATPPRRAPSPGMGMGASGRHMPSPSGPGSL 1518
                                       |..|.|...|                 |
 Worm   963 ---------------------------VSVSSLAEPT-----------------H---------- 973

  Fly  1519 PPGLISKRRGFDDGSSDFSLTPNLNMEYSGPKLYKQPAAKSNRGIILNAVEYCVFPGVVNREAKQ 1583
                                           |||.:...|||||:|.||:::.||||.||...:|
 Worm   974 -------------------------------KLYAKTVTKSNRGLINNALQFSVFPGAVNNATRQ 1007

  Fly  1584 KVLEKIARSEAKHFLVLFRDAGCQFRALYSYQPETDQVTKLYGTGPSQVEEVMFDKFFKYNSGGK 1648
            ..:.::|.|.:||||:||||..||:|.||::...:|...|:.|.||.:..|.|.:..|||:||.|
 Worm  1008 ATITQMASSSSKHFLILFRDQKCQYRGLYTWDEISDTAVKISGQGPPKCTEAMMNSMFKYDSGAK 1072

  Fly  1649 CFSQVHTKHLTVTIDAFTIHNSLWQGKRV 1677
            .|:.:.||||:.|||.|.|.:..||..|:
 Worm  1073 NFTNIATKHLSATIDGFAILDQYWQKARI 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Patronin	NP_001261051.1	CAMSAP_CH	189..272	CDD:432229	24/83 (29%)
		CAMSAP_CC1	612..679	CDD:465344	11/66 (17%)
		PRK10263	<741..>898	CDD:236669	38/160 (24%)
		tolA_full	1271..>1391	CDD:274303	32/124 (26%)
		CAMSAP_CKK	1548..1676	CDD:198119	58/127 (46%)
ptrn-1	NP_001294846.1	CAMSAP_CH	186..270	CDD:432229	26/95 (27%)
		DR0291	<840..>918	CDD:441187	28/102 (27%)
		CAMSAP_CKK	972..1100	CDD:198119	60/185 (32%)