DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patronin and camsap2

DIOPT Version :9

Sequence 1:	NP_001261051.1	Gene:	Patronin / 36978	FlyBaseID:	FBgn0263197	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	XP_017949121.1	Gene:	camsap2 / 100488548	XenbaseID:	XB-GENE-6039325	Length:	1478	Species:	Xenopus tropicalis

Alignment Length:	1864	Identity:	413/1864 - (22%)
Similarity:	667/1864 - (35%)	Gaps:	606/1864 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EIRQARQRASVKWLLSKAFN-NRVPDNLKEPFYRDHENQERLKPQIIVELGNATLYCQT-LANLY 69
            :..:|:...::.||::||:. ..||..|:||||.|..:||.:||.::..|.:|.|||:. ...|.
Frog    27 DFNRAKAACNLSWLVAKAYGAENVPKELQEPFYTDQYDQEHVKPPVVNLLLSADLYCRAGSLILK 91

  Fly    70 SDPNYQSMNHWSIIQTLARKGVPVAESADMPITETVLIQTNPLRINAHMSVIESLMVLYAKEISS 134
            ||.....:.|.::||.||::|:.|.:...: :||..| :..|::::||:::|::||:.|..|:.|
Frog    92 SDTAKPLLGHDAVIQALAQRGLYVTDHEKL-VTERDL-RKKPIQMSAHLAMIDTLMMAYTIEMVS 154

  Fly   135 GDRVMAAIRRISGNNYQAPTGQSYEQALLGWISHACAALKKRIIKE--------VDAGLPDDNGS 191
            .::|:|.:.:.|.....|......|.|::.||:.....||..:.:|        :|......:.|
Frog   155 IEKVIACVHKYSPFFQTADLPYDIEDAVMYWINKVNGHLKSILEQEQRLKMQQNLDPNTTQKSSS 219

  Fly   192 R-----------------LQTPDIPPVRD-FQDLCDGICLALLISYYCPKVVPWTSVRINYLPAV 238
            :                 .|.|.||.:.: .:|..||..::.||.:|||:|:....:......::
Frog   220 KWFWKLVPARYRKEQNLFKQLPCIPLMENILKDGTDGCAISALIHFYCPEVIRLEDICFKESMSL 284

  Fly   239 EDSIHNILLVCNFSQKHLPYTVMHMTPEDVTYMRGSMKLNLVVLLTDLFNLFE------IHPAKC 297
            .||::|:.::..|.|::| ....|.|.||:.|...|:|.|.:|.:.:||..||      :.|.
Frog   285 ADSLYNLQMIQEFCQEYL-NGCCHFTLEDMLYASSSVKTNYLVFMAELFWWFEVVKPSFVQPR-- 346

  Fly   298 VCYPGMDGQVPHSNSFGGGLNRRST------PPNEYQTVQS------------NNFDGN------ 338
            |..|.:......:.|....||||:|      |.|:....:|            :..||.
Frog   347 VLNPNVAAHKVRTPSSAPHLNRRNTIGASSNPRNQQPISESVGPAVIRRSSSMSYVDGQVGTWPK 411

  Fly   339 ------HAEAF-----------VVHKSRGITTLAS----------------------------MH 358
                  |..:|           |...||.|:...|                            :.
Frog   412 EKRSSVHGVSFDISFDKEDGMQVTAPSRPISRSISNEGFSLNMARVPKHIRKNLSFQPINGQGID 476

  Fly   359 SQQQQQL-----------HQQQQHQQQY--HQQPLQQHPSQSQLQIQQQEPLVPARLR--QAKEK 408
            .:.:|.|           |......:||  |..|::......:|..|.:.|.:...|.  ...||
Frog   477 EEWRQMLPNHNVTSTTSDHWDSDDGEQYKRHNGPVENQIEVDELDSQVEAPTIEEALNIIHNPEK 541

  Fly   409 TNVESKADERGDFVAAGRPSNWEQSRRPSFAGRRSRRNSSSEDSQLTIENFGGSQDQLNTLGRYE 473
            |:|.......|.::                         .:.|..|.::.   ||..| |.|.::
Frog   542 TSVSGNQTNNGFYL-------------------------HNHDINLGLQL---SQPGL-TEGNFD 577

  Fly   474 RDRERKLSNTSVGSYPVEPAVAVRSSIADARGTLQLGYDTDSGSEKQDRETEKYSMRRQVSVDNV 538
            ...|.|.:.:     ||.....|.:.|......:.|..|.||       ..:.|::.....:::.
Frog   578 LFEETKGTQS-----PVTDNTEVDTGIHVPSEDIPLTMDEDS-------SLKDYTVSLDSDIEDP 630

  Fly   539 PTVSSHNLSNAGS--------PLPVARHKQHSSDKDYSSNSGMTPDA--------YNDSRSTSGY 587
            ..:.....|..||        |..|:...|..|....||...||..|        :.|.||:...
Frog   631 LKIHQEYGSQIGSVREPVSPCPSSVSGKSQAGSTASSSSGIKMTSFAEQKFRKLNHGDGRSSGSS 695

  Fly   588 DPESTPVRKSSTSSMPASPAAWQLDVGDDDMRSLEN-------ASKLSTIRMKLEEKRRRIEQDK 645
            ..::||  :.|..::|...|..|.   .||...|:.       ||::..:|||||||||.||..|
Frog   696 SQKTTP--EGSELNIPQIVAFGQT---PDDNTVLQGKDTTQLLASEMVQLRMKLEEKRRAIETQK 755

  Fly   646 RKIEMALLRHQEKEDLESCPDVMK----------WETMSNESKRTPDMDPVDLDKYQQSIAIMNM 700
            :|:|.|..|.::|....:...|:|          .|....||.:.|
Frog   756 KKVEAAFTRQRQKMGRTAFLTVVKKKGDIISPLREEPAGGESDKAP------------------- 801

  Fly   701 NLQDIQQDIHRLATQQSQMQAQHLQAQQLMQAQQIANMLNQQQTYGSQQHLADHHYQQQRPMQQS 765
                                                     .:..|....::||...
Frog   802 -----------------------------------------AECEGDSLRISDHFVD-------- 817

  Fly   766 FGSSPHLPQAYNAPVSAYSSRPPSRDPYQQQLHHQQQQPMPMPQPMQYVNEHGQYMSPPQPAHYM 830
                       ||.|..      ..||                      |:....|||..|.
Frog   818 -----------NANVKL------KVDP----------------------NQAKWLMSPTTPG--- 840

  Fly   831 PQQAQQPQSIYSDNGAAYNHSNHSPYGGTPQYRSSVVYDDYGQPTNHFYLHESSPQPQAHQHPQR 895
              ..::|.::.|.     :..|.|. |...:|..|:  :......|..           .|..||
Frog   841 --DPEKPWNLTSP-----SEENMSE-GDILEYTKSI--EKLNSSLNFL-----------QQEMQR 884

  Fly   896 RTWAHSAAAAAYEQQQQIQPSLVDVNAWQTQQHQKQKQTWMNRPPSSAGAPSPGSFMLHQNGGGG 960
                     .|.:|...:|              .::||.|:..||.    |||
Frog   885 ---------LALQQGMLMQ--------------MREKQAWVISPPQ----PSP------------ 910

  Fly   961 GGGGGGGELQHLFQVQASPQHGQRQVSGSNGVQRQQSLTNLRDNRSPKAPQNMGMPMGMPMQQED 1025
                         |.|..||:..:|.:       :.|:|     .||
Frog   911 -------------QKQLPPQNTTKQTT-------KPSVT-----WSP------------------ 932

  Fly  1026 MMAPQSICFIGDEEDVDELERNIIESMQSTHISDFVHQQQQQHQHQQQLQQQQRLQGHSGRGSSS 1090
              ||   ||             .|||.:|.|.|
Frog   933 --AP---CF-------------TIESPRSAHRS-------------------------------- 947

  Fly  1091 EDYDSGEMISNKLNITSGNLTYRIPSPSRPSIQANSFQDPRAMAAASGGEDQPPEKGF------- 1148
                  ...|.|..::....|.|||.|:...|...:    |.:......:..|..:.|
Frog   948 ------PQTSAKKTVSFPAKTQRIPRPNDLKIAPLN----RTLTPPQSVDSLPRLRRFSPSQTQT 1002

  Fly  1149 --YISFDDEQPKRPKPPLRAKRSPKKESPPGSRDSVDNQATLKRESLSHLHNNNNIGFGNDDVNS 1211
              ::.|.|::    ||...::.:  |||  |..|.|.:|...:.:.:|       :...:|.::.
Frog  1003 RSFVYFGDDR----KPTTDSQEA--KES--GVADEVSSQVKYRSDEVS-------VKEKSDVISD 1052

  Fly  1212 KPVTRHSIHGLNNSNSVK-SPGNATYNKYTDEPPIQLRQLAVSGAMSPTSNERHHLDDVSNQSPQ 1275
            ||.            .|| .|..:|.::...:|.|:      :..::|...:..|....::::..
Frog  1053 KPA------------EVKIRPIESTVSEVLSQPIIE------TVCVTPNDEQFSHRSLSASKTGS 1099

  Fly  1276 QTQQPMSPTRLQQSSNNAEA----------AKNKALVIGADSTNLDPESVDEMERRKEKIMLLSL 1330
            ..:.|:|  :||.|....|.          ::::.:..|....: |.:..::|..::..::...|
Frog  1100 LIEVPLS--KLQPSDEKPEENELEPDKEQNSEDQKVCCGFFFKD-DRQEENDMAAKRAALLEKRL 1161

  Fly  1331 QRRQQQEEAKARKEIEASQKREKEREKEEERARKKEEQMARRAAILEQHRLKKAIEEAEREGKTL 1395
            :|.::.::.|..:|:|...|:|:.|.|.||...|||::.||:..|.:::..:|
Frog  1162 RREREVQQRKQEQEVELEHKKEEARRKSEEERSKKEDEKARKEFIKQEYLRRK------------ 1214

  Fly  1396 DRPDLHVKLQSHSSTSTTPRLRQQRTTRPRPKTIHVDDASVDISEASSISSRGKKGSSSNLTGYG 1460
                 .:||.:...:...||....:..:||||:||.|..    .|:.....|....||.:|....
Frog  1215 -----QLKLMADMDSIIKPRANLGKPRKPRPKSIHRDHQ----LESPRTPVRAPPVSSLSLASLN 1270

  Fly  1461 QLSSNSMKRDYYRGSQDSLTVKDSGLGRATPPRRAPSPGMGMGASGRHMPSPSGPGSLPPGLISK 1525
            ...:.|:..|                      :|.|||          ..|.|..|.|.||....
Frog  1271 TGDNESVNSD----------------------KRTPSP----------FRSESVEGYLSPGRCGS 1303

  Fly  1526 RRGFDD------GSSDFSLTPNLNMEYS-----------GPKLYKQPAAKSNRGIILNAVEYCVF 1573
            |.|..|      .||..|.|     ||:           ||||||:|:||||:.||.||:.:|..
Frog  1304 RNGEKDWENASTTSSVASAT-----EYTDIGSRIGHYILGPKLYKEPSAKSNKYIIQNALSHCCL 1363

  Fly  1574 PGVVNREAKQKVLEKIARSEAKHFLVLFRDAGCQFRALYSYQPETDQVTKLYGTGPSQVEEVMFD 1638
            .|.||...|.|:||::.:|.|.:||:||||||||||::|:|..|.:::.||.|.||..:...|.|
Frog  1364 AGKVNEGQKNKILEEMEKSNANNFLILFRDAGCQFRSVYTYCQEMEEINKLTGIGPRSISRKMID 1428

  Fly  1639 KFFKYNSGGKCFSQVHTKHLTVTIDAFTIHNSLWQGKRVQLPSK 1682
            ..:||||..|.||.:..|.|:.::||.|||:.|||.||...|.|
Frog  1429 GLYKYNSDRKQFSHIPAKTLSASVDAVTIHSHLWQAKRPVTPKK 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patronin	NP_001261051.1	CAMSAP_CH	189..272	CDD:288798	25/100 (25%)
		CAMSAP_CC1	612..679	CDD:293700	27/83 (33%)
		tolA_full	1271..>1391	CDD:274303	27/129 (21%)
		CAMSAP_CKK	1549..1667	CDD:285846	57/117 (49%)
camsap2	XP_017949121.1	CAMSAP_CH	238..317	CDD:314792	24/79 (30%)
		CAMSAP_CC1	730..780	CDD:374981	20/49 (41%)
		PTZ00121	<1010..1223	CDD:173412	51/265 (19%)
		ARGLU	<1142..1241	CDD:373772	26/115 (23%)
		CAMSAP_CKK	1339..1457	CDD:370058	57/117 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5008
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2078
OMA	1	1.010	-	-		QHG47141
OrthoDB	1	1.010	-	-		D324856at33208
OrthoFinder	1	1.000	-	-		FOG0001093
OrthoInspector	1	1.000	-	-		otm48466
Panther	1	1.100	-	-	LDO	PTHR21595
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X931
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.170