DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4853 and Rasgef1c

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001334391.1	Gene:	Rasgef1c / 74563	MGIID:	1921813	Length:	469	Species:	Mus musculus

Alignment Length:	448	Identity:	169/448 - (37%)
Similarity:	255/448 - (56%)	Gaps:	54/448 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 PKKGNLDSVVNLLINN----NTKDLRFAFLTTSRLFSPPHQLLSKII----------------AK 331
            |...:||:::..|:..    ..|...|.||.:||||..|.:||:::.                |:
Mouse    41 PSSASLDTLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKAR 105

  Fly   332 IDNEEENVLRLLNEWLDTCPGDFSHELLLQELENKRNVKGLAAFLDGIPQALAQKDENGRSQLNN 396
            :......:|:||.||.:|.|.||..|..:..|.:             :...::..||...|:::.
Mouse   106 VRKFGAKLLQLLAEWTETFPRDFEEESTIGHLTD-------------VVGRISPCDETYGSRVHQ 157

  Fly   397 LL-TKQSSASSLGR--QSSIKSLKRFA------ANVYKTDNVLNNCSSAFELAHQLYAIEYAYLS 452
            || |.....:|||:  :|.:.:.|..:      |::::  .:|..||..:.||.||..:|...|.
Mouse   158 LLQTLHQKLASLGQGPESLVGADKPISYRTKPPASIHR--ELLGVCSDPYTLAQQLTHVELERLR 220

  Fly   453 QIRLEEFVE-ILEKDELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQ 516
            .|..||||: .:.||.|        |||..........:::||:|||:|.||.||||....||.|
Mouse   221 HIGPEEFVQAFVNKDPL--------AGTKPRFSDKTNNVEAYVKWFNRLCYLVATEICMPAKKKQ 277

  Fly   517 RAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQTTKFEGLEHQMDPSSNFL 581
            |||:|:|:::.|.||||.|||||||||::.:|::.::|||||||||:|.||..|||||||:.||.
Mouse   278 RAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFFILEHQMDPTGNFC 342

  Fly   582 NYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINESHETKLANGYINFEKCLHLGTQLR 646
            |||:.::.|..||....::. |:.:||||||.:||::.:||....:|.||::||||.|.|..|:.
Mouse   343 NYRTALRGAAHRSLTAHSSR-EKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVG 406

  Fly   647 NFGKWQRLDCPYEQLPSVVSYLLKAEVLSEDLLMKASYESEPPETGEEKDHYKTLKAA 704
            .|..|::::||:||.||:..||..|.:.|||.|..||||||.||:..||:.:|:|:::
Mouse   407 EFITWKQVECPFEQDPSITHYLYTAPIFSEDGLYLASYESESPESQTEKERWKSLRSS 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	26/96 (27%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	96/200 (48%)
Rasgef1c	NP_001334391.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9575
eggNOG	1	0.900	-	-		E1_KOG3541
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246323at33208
OrthoFinder	1	1.000	-	-		FOG0001827
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104212
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1189
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.780