DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4853 and rasgef1b

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	XP_031756070.1	Gene:	rasgef1b / 549667	XenbaseID:	XB-GENE-1015760	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	456	Identity:	169/456 - (37%)
Similarity:	263/456 - (57%)	Gaps:	69/456 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 GNLDSVVNLLINN----NTKDLRFAFLTTSRLFSPPHQLLSKII----------------AKIDN 334
            |:|::::..|:.|    ..:...|.||.:||||..|.:|::::.                :::..
Frog   156 GSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFIHPSELMARVCHVCMEQQRLNEPGLDKSQVRK 220

  Fly   335 EEENVLRLLNEWLDTCPGDFSHELLLQELEN------------KRNVKGLAAFLDGIPQALAQKD 387
            ....:|:||.||.:|.|.||..|.:::.|::            ::||:.:   :..:.:.||
Frog   221 IAPKILQLLTEWTETFPYDFRDERMMRNLKDTAHRITNGDEMYRKNVQQI---IQNLIRKLA--- 279

  Fly   388 ENGRSQLNNLLTKQSSASSLGRQSSIK----SLKRFAANVYKTDNVLNNCSSAFELAHQLYAIEY 448
              ..:|...|:|| .:|.|..|.:.:|    |::|         :::..||..:.:|.||..||.
Frog   280 --SLTQYEELITK-INAQSTDRMTVLKTKPQSIQR---------DIITVCSDPYTVAQQLTHIEL 332

  Fly   449 AYLSQIRLEEFVE-ILEKDEL----KTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEI 508
            ..||.|..||||: .::||.|    :.|.|..|         ....:::||:|||:||||.||||
Frog   333 ERLSYIGPEEFVQAFVQKDPLDNNEQNCYSDRK---------KPRNLEAYVEWFNRLSYLVATEI 388

  Fly   509 LKLGKKSQRAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQTTKFEGLEHQ 573
            ....||..||:||:|:::.|.||||.|||||||||::.:|::.::|||||||||:|.||:.||||
Frog   389 CMPVKKKHRARMIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQ 453

  Fly   574 MDPSSNFLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINESHETKLANGYINFEKC 638
            |||||||.|||:.::.|..||....:|. |:.:|||.||.:||::.:||...::|.||::||||.
Frog   454 MDPSSNFYNYRTALRGAAQRSLTAHSNR-EKIVIPFCSLLIKDIYFLNEGCTSRLPNGHVNFEKF 517

  Fly   639 LHLGTQLRNFGKWQRLDCPYEQLPSVVSYLLKAEVLSEDLLMKASYESEPPETGEEKDHYKTLKA 703
            ..|..|:..|..|::::||:|:...::.|:|.|.:.|||.|..||||||.||...|||.:|||::
Frog   518 WELAKQVSEFMTWKQVECPFEKDRKILHYVLTAPIFSEDALYLASYESEGPENHIEKDRWKTLRS 582

  Fly   704 A 704
            |
Frog   583 A 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	24/94 (26%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	99/204 (49%)
rasgef1b	XP_031756070.1	REM	157..281	CDD:100121	27/131 (21%)
rasgef1b	XP_031756070.1	RasGEF	323..518	CDD:395492	100/204 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9639
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246323at33208
OrthoFinder	1	1.000	-	-		FOG0001827
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1189
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.020