DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4853 and rasgef1bb

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001003479.1	Gene:	rasgef1bb / 445085	ZFINID:	ZDB-GENE-040801-220	Length:	475	Species:	Danio rerio

Alignment Length:	456	Identity:	169/456 - (37%)
Similarity:	250/456 - (54%)	Gaps:	68/456 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 GNLDSVVNLLINN----NTKDLRFAFLTTSRLFSPPHQLLSKII----------------AKIDN 334
            |:|::::.||:..    ..:...|.||.:||||..|.:|:|::.                .:|.:
Zfish    43 GSLEALIQLLVPTVDYYPDRSYIFTFLLSSRLFLNPFELMSRVCYLGVDHHRVGDPQMDKKRIRD 107

  Fly   335 EEENVLRLLNEWLDTCPGDFSHELLLQELENKRNVKGLAAFLDGIPQALAQKDENGRSQLNNL-- 397
            ....:::||.||.:|.|.||..|.:::.|:.             :...||..||..|..:..|
Zfish   108 IAPKIVQLLTEWTETFPYDFRDERMMRSLKE-------------MTHRLAFGDELSRRAMQRLIQ 159

  Fly   398 ---------------LTKQSSASSLGRQSSIKSLKRFAANVYKTDNVLNNCSSAFELAHQLYAIE 447
                           |...|:|:::.|..::||.::.   |.:.|.|||.|...|..|.||..||
Zfish   160 RLLRKLTTLGQYEESLATTSAAAAIDRPVALKSKQQL---VRRDDCVLNLCDDPFIFAQQLTHIE 221

  Fly   448 YAYLSQIRLEEFVEILEK----DELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEI 508
            ...||.|..||||....:    |..|:..|:.||..|          ::||:|||:|||||||||
Zfish   222 MERLSYIGPEEFVRAFAQKRPSDNHKSFFSKRKASNL----------EAYVEWFNRLSYLTATEI 276

  Fly   509 LKLGKKSQRAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQTTKFEGLEHQ 573
            ....||..||::::|:::.|.||||.|||||||||:|.:|:..::||||||.||.|.||:.|.||
Zfish   277 CMPVKKKHRARVLEFFIDVAQECFNIGNFNSLMAIITGMNMNPVSRLKKTWGKVNTDKFDILVHQ 341

  Fly   574 MDPSSNFLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINESHETKLANGYINFEKC 638
            |||||||.:||:.::.|..||.....:: |..:|||||||:||::.:||....:|:||:|||||.
Zfish   342 MDPSSNFYSYRTALRGATQRSSTAHTSQ-EMIVIPFFSLFIKDIYFLNEGCANRLSNGHINFEKF 405

  Fly   639 LHLGTQLRNFGKWQRLDCPYEQLPSVVSYLLKAEVLSEDLLMKASYESEPPETGEEKDHYKTLKA 703
            ..|..|:..|..|:::.||:|:....:.||:.|.|.|||.|..||||||.||...|:|..::|::
Zfish   406 WELAKQVSEFLSWRQVICPFERDRKTLQYLISAPVFSEDELQLASYESEGPENNLERDTRRSLRS 470

  Fly   704 A 704
            :
Zfish   471 S 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	25/94 (27%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	98/203 (48%)
rasgef1bb	NP_001003479.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		REM	44..168	CDD:100121	30/136 (22%)
		RasGEF	213..406	CDD:279011	99/203 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..475		8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593568
Domainoid	1	1.000	71	1.000	Domainoid score	I9376
eggNOG	1	0.900	-	-		E1_KOG3541
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246323at33208
OrthoFinder	1	1.000	-	-		FOG0001827
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104212
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1189
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.710