DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4853 and Rgl

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster

Alignment Length:	740	Identity:	147/740 - (19%)
Similarity:	253/740 - (34%)	Gaps:	228/740 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 RNGQILDERTVETKENFNHQS---HQKEIWHPV-------KQQSALARATPENALKYRTTSNSTF 159
            |..|...:...::|.:::|.:   .:|:...||       |.|.|..|.:...:.|.|  .||::
  Fly    74 RQQQQQQQDAKDSKRHYHHHTCPRQRKKSMTPVEPTHLCQKHQEAKQRRSRSASAKPR--RNSSY 136

  Fly   160 ASQATDSDERPVDPLGRQLNQTFSNASLMSSSSAITGSDQVIGSVSSTTIGDKSSNISSCDSGH- 223
            .|.    |:..|            :::::::...:..|.:.:.:.:..|:.:.|.......:.:
  Fly   137 HSY----DDLDV------------SSAVLNAERKVVASLKYLCACTGATLRNLSKKTKDLHAKNY 185

  Fly   224 ----------------DGLFHSVSMSAPWSHPRDTLTDSLYCDIPSSADESDAVSILNTHLKITE 272
                            :.:|........:..|..|          :|.|..|.:|    ||
  Fly   186 TYTKPTWRLWGEEHEKNAIFTVYLKKVRYHRPTPT----------ASNDSDDEIS----HL---- 232

  Fly   273 PFDCQTAPVYAKDIPKKGNLDSVVNLLINNNTK-DLRF--AFLTTSRLFSPPHQLLSKIIAKIDN 334
              :.:|..|   ...|...|..:|..|..::.: :..|  .||:|.|.||.|.|:||.:..:.|.
  Fly   233 --EWETVRV---RFVKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDA 292

  Fly   335 EEENVLRLL------NEWLDTCPGDFSHELLLQELENKRNVKGLAAFLDGIPQALAQKDENGRSQ 393
            ..|..|..|      .:.:|..   :.....:.|...|..|..|..:|||.|:   ...|:...|
  Fly   293 LHEKHLEELEQAQQNGQVMDPA---YDPHASIHEQHKKTLVSALHVWLDGFPE---DWHEDNLQQ 351

  Fly   394 LNNLLTKQSSASSLGRQSSIKSLKRFAANVYK-----------TDN------------------V 429
            :....||:...|.|    .||.|.|....:.:           ::|                  :
  Fly   352 ILAFATKRLKRSDL----HIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMI 412

  Fly   430 LNNCSSAFELAHQLYAIEYAYLS---------------------QIRLEEFVEILEKDELK---- 469
            ..:..|:::|..|...:   |||                     .:.:..|.|.|.:.:.:
  Fly   413 PTHYGSSYDLTDQFNGM---YLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKR 474

  Fly   470 ----TCISQT--KAGTLGSNCISQVTIDSYVQWFNQLSYLTATEIL--KLGKKSQRAQMIDFWVE 526
                .|:..|  :..:.||.     |:.:.:..||.:.:...:.||  :| |..:||..|..|::
  Fly   475 LIPHQCLGHTWARRDSGGSE-----TVVATINQFNAVLFRVVSSILIDRL-KPQERALNISRWID 533

  Fly   527 TALECFNTGNFNSLMAILTALNLTAIARLKKTWAKV-------------------------QTTK 566
            .|.|.....||:||.||::|||..:|.||.|.|..:                         :..|
  Fly   534 IAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLK 598

  Fly   567 FEGLEHQMDPSSNFLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDL---HAINESHETKL 628
            .||.....||.|:..: |...|..:     .:..:.....||:...||.||   |..|..:.|:
  Fly   599 REGTAKNPDPGSDHSD-RHLQKLIL-----NLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTE- 656

  Fly   629 ANGYINFEKCLHLGTQLRNFGKWQRLDCPYEQLPSVV-------SYLLKAE-----------VLS 675
             |..|||:|              :|.:  :|.|..:.       :|.|:|:           |..
  Fly   657 -NKLINFDK--------------KRKE--FEVLAQIKLLQGAANTYNLQADALFDHWFNSMPVFD 704

  Fly   676 EDLLMKASYESEPPETGEEKDHYKT 700
            |....:.|...|||.....|....|
  Fly   705 EREAFELSCRLEPPPPAPRKSVVST 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	21/85 (25%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	60/260 (23%)
Rgl	NP_001261814.1	REM	246..378	CDD:100121	37/141 (26%)
		RasGEF	454..719	CDD:214539	67/294 (23%)
		RalGDS_RA	858..946	CDD:176351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467911
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940