DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4853 and Epac

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001097202.2	Gene:	Epac / 35588	FlyBaseID:	FBgn0085421	Length:	1006	Species:	Drosophila melanogaster

Alignment Length:	661	Identity:	137/661 - (20%)
Similarity:	243/661 - (36%)	Gaps:	175/661 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 TVETKENFNHQSHQKEIWHPVKQQSALARATPENALK-YRTTSNSTFASQATDSDERPVDPLGRQ 177
            |:..|||..|                |.|...|:..: .|....:|...|....|...::.:.:|
  Fly   431 TIVLKENNCH----------------LLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQ 479

  Fly   178 LNQ-TFSNASLMSSSSAITGSDQVIGSVSSTTIGDKSSNISSCDSGHDG--LFHSVSMSAPWSHP 239
            ..| :....::||.:.|     :::..:..|.:|   .::...|...|.  |.|.|.|  |....
  Fly   480 RGQHSAFKYTVMSGTPA-----KMLEHLLETRLG---QSVGGMDPFLDDFLLTHIVFM--PVVQL 534

  Fly   240 RDTLTDSLYCDIPSSAD-ESDAVSILN----------------THLKITEPFDCQTAPVYAKDIP 287
            .|.|.:..:||....|. ..|...|:|                .|....||..|......|.::.
  Fly   535 VDELANYFHCDAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVE 599

  Fly   288 KKGNLDSVVNLLINNNTKDLRFAFLTTSR---------------LFSPPHQLLSKIIAKIDNEEE 337
            ...:|:...:::.|..|:..|:.......               ||| .:...||.:.:.|  ::
  Fly   600 ADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFS-GNATPSKTVIRPD--DD 661

  Fly   338 NVLRL----------------LNEWLDTCPGD------FSHELLLQELEN--KRNVKGLAAFLD- 377
            .:.|:                ..|.:..|..|      ...:|:|.|:::  :|:|     |.|
  Fly   662 IIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSV-----FKDN 721

  Fly   378 --GIPQALAQKDENGR---------SQLNNLLTKQSSASSLGRQSSIKSLKRFAANVYKTDNVLN 431
              .||..|:.   |||         ..|..|..::.....:.....|.|.|
  Fly   722 DVSIPTGLSL---NGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTK-------------- 769

  Fly   432 NCSSAFELAHQLYAIEYAYLSQIRLEEFVEILEKDELKTCISQTKAGTLGSNCISQVTIDSYVQW 496
                  |||:.:...|:        :.|..:.|.:.|.....:...|.:.:|      :|.:::.
  Fly   770 ------ELAYHITLFEW--------DLFWAVHEYELLYHTFGRHHFGKITAN------LDVFLRR 814

  Fly   497 FNQLSYLTATEILKLGKKSQRAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAK 561
            ||::.|...||::.....|:|..::..:::.|..|....|.|:..|::..|:..|::||::||.|
  Fly   815 FNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEK 879

  Fly   562 VQT---TKFEGLEHQMDPSSNFLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINES 623
            :.:   ..|:..|..:|||.|.            |:.|....:::..:|||..|.|||:...:|.
  Fly   880 IPSKFRKIFQEFEALIDPSRNH------------RAYRVFVGKLQPPLIPFMPLLLKDMTFAHEG 932

  Fly   624 HETKLANGYINFEKCLHLGTQL---------RNFGKWQRLDCPYEQLPSVV-SYLLKAEVLSEDL 678
            ::|.| :|.:|||| :|:..|.         |:.|    |:.|..:....| ||:....|:....
  Fly   933 NKTSL-DGLVNFEK-MHMMAQTMRTIRFCRSRSLG----LEPPSPKSEGEVRSYISSFRVIDNQR 991

  Fly   679 LMKA-SYESEP 688
            ::.| |.:.||
  Fly   992 VLTAMSQKVEP 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	17/113 (15%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	51/202 (25%)
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999	10/47 (21%)
		Crp	373..525	CDD:223736	22/117 (19%)
		RasGEF_N	489..594	CDD:279012	24/114 (21%)
		UBQ	665..>714	CDD:294102	7/48 (15%)
		RasGEF	766..1002	CDD:214539	66/287 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467903
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940