DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4853 and Sos

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	138/758 - (18%)
Similarity:	239/758 - (31%)	Gaps:	242/758 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LEGQMPSVEHLNQLLFRAGLAQQPIEVETSLTVKSSLTTTEEVLVSR--NGQILDERTVETKENF 121
            |......:|...|:   .||. .|:..:.. .|.:||:...:|.||.  ..|:..|||.|.:...
  Fly   407 LSSSQDDIESFEQV---QGLL-HPLHCDLE-KVMASLSKERQVPVSGRVRRQLAIERTRELQMKV 466

  Fly   122 NHQSHQ---------------------KEIWHP----------------VKQQSALARATPENAL 149
            .|...:                     |.||..                .|:|:..|.||   |.
  Fly   467 EHWEDKDVGQNCNEFIREDSLSKLGSGKRIWSERKVFLFDGLMVLCKANTKKQTPSAGAT---AY 528

  Fly   150 KYRTTSNSTFASQATDSDERPVDPLGRQLNQTFSNASLMSSSSAITGSDQVIGSVSSTTIGDKSS 214
            .||.  ...:..:..|.::||...   .|..:|..|..|.....:|..:.
  Fly   529 DYRL--KEKYFMRRVDINDRPDSD---DLKNSFELAPRMQPPIVLTAKNA--------------- 573

  Fly   215 NISSCDSGHDGLFHSVSMSAPWSHPRDTLTDSLYCDIPSSADESDAVSILNTHLKITEPFDCQTA 279
                                  .|..|.:.|.|.. |..|..:....|||. .::...|....:.
  Fly   574 ----------------------QHKHDWMADLLMV-ITKSMLDRHLDSILQ-DIERKHPLRMPSP 614

  Fly   280 PVYAKDIPKKGN-------------------LDSVVNLLINNNTKDLRF--AFLTTSRLFSPPHQ 323
            .:|...:|..|:                   |..::..|..:...|..|  .||||.|.|..|.|
  Fly   615 EIYKFAVPDSGDNIVLEERESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQ 679

  Fly   324 LLSKIIAKI-------------------------DNEEEN--------------------VLRLL 343
            ||..::.:.                         |.|.:|                    ||.:|
  Fly   680 LLQLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVL 744

  Fly   344 NEWLDTCPGDFSHE-LLLQELEN---KRNVKGLAAFLDGIPQALAQKDENGRSQLNNLLTKQSSA 404
            ..|:|....||..: :||::|.|   ..|.|.:..::|.:.:.:.:|:|..:|....:.......
  Fly   745 RHWVDHHFYDFEKDPMLLEKLLNFLEHVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDP 809

  Fly   405 SSLGRQSSIKSLKRFAANVYKTDNVLNNCSSAFELAHQLYAIEYAYLSQIRLEEFV--------- 460
            ..:....|:.:           |.:........|||.||..:|:.....::..|.|
  Fly   810 PPIEHHLSVPN-----------DEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDK 863

  Fly   461 EILEKDELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQRAQMIDFWV 525
            |:...:.||.....|                :..:|..:       .|.:.....:|..::...:
  Fly   864 EVKSPNLLKIMKHTT----------------NVTRWIEK-------SITEAENYEERLAIMQRAI 905

  Fly   526 ETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQTTKFEGLEHQMDPSSNFLNYRSTMKAA 590
            |..:......|||.:::|:.|:...::.||:.|        |:||..:         ||..::..
  Fly   906 EVMMVMLELNNFNGILSIVAAMGTASVYRLRWT--------FQGLPER---------YRKFLEEC 953

  Fly   591 VWRSE------REMANEIERAIIPFFSLFLKDLHAINESHETKLANGYINFEKCLHLGTQLRNFG 649
            ...|:      :|....|....:|||..:|.::..:.|.:...|||            |:|.||.
  Fly   954 RELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLAN------------TELINFS 1006

  Fly   650 KWQRLDCPYEQLPSVVSYLLKAEVLSEDLLMKASYESEPPETG 692
            |.:::   .|.:..:..|..:...|:|:..::..:|...|..|
  Fly  1007 KRRKV---AEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNG 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	28/143 (20%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	40/214 (19%)
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091	6/28 (21%)
		PH_SOS	476..586	CDD:269963	23/154 (15%)
		PH	482..587	CDD:278594	23/150 (15%)
		RasGEFN	637..791	CDD:214571	31/153 (20%)
		RasGEF	825..1062	CDD:238087	52/277 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467907
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940