DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4853 and rasgef1ba

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	XP_005165335.1	Gene:	rasgef1ba / 327572	ZFINID:	ZDB-GENE-030131-5783	Length:	531	Species:	Danio rerio

Alignment Length:	571	Identity:	193/571 - (33%)
Similarity:	293/571 - (51%)	Gaps:	120/571 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 TIGDK-SSNISSCDS-GHDGLFHSVSMSAPWSHPRDTLTDSLYCDIPSSADESDAVSILNTHLKI 270
            |:.:| :|.:..|.| .|.||.|....       |.|:..:| .:.|.....:|       .:..
Zfish    12 TLPEKGASPMFECRSQPHIGLRHVTKQ-------RPTIFGTL-IEKPLGDHNAD-------KMPQ 61

  Fly   271 TEPFDCQTAPV-------YAKDIPK-----------------KGNLDSVVNLLINN----NTKDL 307
            |.||     ||       |.|::.|                 .|:|::::..|:..    ..:..
Zfish    62 TPPF-----PVMYGSTNGYNKNLYKAKEEDYEGLYYHDNNLISGSLEALIEHLVPTVAYYPDRTY 121

  Fly   308 RFAFLTTSRLFSPPHQLLSKII----------------AKIDNEEENVLRLLNEWLDTCPGDFSH 356
            .|.||.:||||..|::|:||:.                |::......:|:||.||.:|.|.||..
Zfish   122 IFTFLLSSRLFLHPYELMSKVCHLCVDQQRLSDPQADKARVRKIAPKILQLLTEWTETFPYDFRD 186

  Fly   357 ELLLQELEN------------KRNVKGLA-------AFLDGIPQALAQKDENGRSQLNNLLTKQS 402
            |.:::.|:.            ::.|:.:.       ..|....:|||:.:.:...:|..|.||.
Zfish   187 ERMMKSLKELTHRLSTGEDLYRKAVQQMTQTLIRKLTTLSQYEEALAKINSSVTDRLTVLKTKP- 250

  Fly   403 SASSLGRQSSIKSLKRFAANVYKTDNVLNNCSSAFELAHQLYAIEYAYLSQIRLEEFVE-ILEKD 466
                       :|::|         ::|..|:..|.||.||..||...||.|..||||: .::||
Zfish   251 -----------QSIQR---------DILTICNDPFTLAQQLTHIELERLSYIGPEEFVQAFVQKD 295

  Fly   467 EL---KTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQRAQMIDFWVETA 528
            .|   |.|.|..|..:         .:::||:|||:||||.||||....||..||::|:|:::.|
Zfish   296 PLDNDKNCFSDHKKAS---------NLEAYVEWFNRLSYLVATEICMPVKKKHRARVIEFFIDVA 351

  Fly   529 LECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQTTKFEGLEHQMDPSSNFLNYRSTMKAAVWR 593
            .||||.|||||||||:|.:|::.::|||||||||:|.||:.|||||||||||.|||:.::.|..|
Zfish   352 RECFNIGNFNSLMAIITGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGATQR 416

  Fly   594 SEREMANEIERAIIPFFSLFLKDLHAINESHETKLANGYINFEKCLHLGTQLRNFGKWQRLDCPY 658
            |....::. |:.:||||||.:||::.:||....:|.||::||||...|..|:..|..|::::||:
Zfish   417 SITAHSSR-EKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVTEFMTWKKVECPF 480

  Fly   659 EQLPSVVSYLLKAEVLSEDLLMKASYESEPPETGEEKDHYKTLKAARKSNT 709
            ::...::.|||.|.|.|||.|..||||||.||...|||.:|:|:::..:.|
Zfish   481 DRDRKILQYLLTAPVFSEDALYLASYESEGPENNMEKDRWKSLRSSLLNRT 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	27/113 (24%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	101/203 (50%)
rasgef1ba	XP_005165335.1	REM	101..225	CDD:100121	26/123 (21%)
rasgef1ba	XP_005165335.1	RasGEF	267..461	CDD:279011	102/203 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593566
Domainoid	1	1.000	71	1.000	Domainoid score	I9376
eggNOG	1	0.900	-	-		E1_KOG3541
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246323at33208
OrthoFinder	1	1.000	-	-		FOG0001827
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104212
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1189
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.710