DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4853 and RASGEF1C

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_778232.2	Gene:	RASGEF1C / 255426	HGNCID:	27400	Length:	466	Species:	Homo sapiens

Alignment Length:	487	Identity:	179/487 - (36%)
Similarity:	266/487 - (54%)	Gaps:	59/487 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 IPSSADESDAVSILNTHLKITEPFDCQTAPVYAKD-IPKKGNLDSVVNLLINN----NTKDLRFA 310
            :|.:...||.|:..:.....|||.|.:.|.....| .|...:|::::..|:..    ..|...|.
Human     1 MPQTLSASDMVTPGSLSPPPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYYPEKAYIFT 65

  Fly   311 FLTTSRLFSPPHQLLSKII----------------AKIDNEEENVLRLLNEWLDTCPGDFSHELL 359
            ||.:||||..|.:||:::.                |::......:|:||.||.:|.|.||..|..
Human    66 FLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQLLAEWTETFPRDFQEEST 130

  Fly   360 LQELENKRNVKGLAAFLDGIPQALAQKDENGRSQLNNLL---------TKQSSASSLGRQSSIKS 415
            :..|   ::|.|          .:|..||..|.:::.||         .:|.....:|....|..
Human   131 IGHL---KDVVG----------RIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPISY 182

  Fly   416 LKRFAANVYKTDNVLNNCSSAFELAHQLYAIEYAYLSQIRLEEFVE-ILEKDELKTCISQTKAGT 479
            ..:..|::::  .:|..||..:.||.||..:|...|..|..||||: .:.||.|    :.||.
Human   183 RTKPPASIHR--ELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPL----ASTKP-- 239

  Fly   480 LGSNCISQVT--IDSYVQWFNQLSYLTATEILKLGKKSQRAQMIDFWVETALECFNTGNFNSLMA 542
                |.|..|  :::||:|||:|.||.||||....||.||||:|:|:::.|.||||.||||||||
Human   240 ----CFSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMA 300

  Fly   543 ILTALNLTAIARLKKTWAKVQTTKFEGLEHQMDPSSNFLNYRSTMKAAVWRSEREMANEIERAII 607
            |::.:|::.::|||||||||:|.||..|||||||:.||.|||:.::.|..||....::. |:.:|
Human   301 IISGMNMSPVSRLKKTWAKVRTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSR-EKIVI 364

  Fly   608 PFFSLFLKDLHAINESHETKLANGYINFEKCLHLGTQLRNFGKWQRLDCPYEQLPSVVSYLLKAE 672
            |||||.:||::.:||....:|.||::||||.|.|..|:..|..|::::||:||..|:..||..|.
Human   365 PFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTAP 429

  Fly   673 VLSEDLLMKASYESEPPETGEEKDHYKTLKAA 704
            :.|||.|..||||||.||...||:.:|.|:::
Human   430 IFSEDGLYLASYESESPENQTEKERWKALRSS 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	25/96 (26%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	98/202 (49%)
RASGEF1C	NP_778232.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		10/35 (29%)
		REM	42..160	CDD:100121	33/130 (25%)
		RasGEF	200..447	CDD:214539	122/257 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9711
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246323at33208
OrthoFinder	1	1.000	-	-		FOG0001827
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104212
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1189
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.880