Protein Alignment CG4853 and R05G6.10

DIOPT Version :9

• Sequence 1: NP_611222.2
• Gene: CG4853 / 36974
• FlyBaseID: FBgn0034230
• Length: 709
• Species: Drosophila melanogaster
• Sequence 2: NP_001294201.1
• Gene: R05G6.10 / 177527
• WormBaseID: WBGene00019902
• Length: 547
• Species: Caenorhabditis elegans
• Alignment Length: 652
• Identity: 186/652 - (28%)
• Similarity: 281/652 - (43%)
• Gaps: 179/652 - (27%)

  Fly   121 FNHQSHQKEIWHPVKQQSALARATPENALKYRTTS-----------------NSTFASQATDSDE 168
            |.||.     |.|::::.  ||::..|..|.:.|:                 |||.....:....
 Worm     8 FWHQP-----WSPMRRKR--ARSSNPNGCKTKPTTLEVDGATENNNGKLILPNSTSQPMLSTQSA 65

  Fly   169 RPVDPLGRQLNQTFSNASLMSSSSAITGSDQVIGSVSSTTIGDKSSNISSCDSGHDGLFHSVSMS 233
            |..:.|.|:       |::::||.:.||...:...||:..:.
 Worm    66 RGYNTLPRR-------AAILTSSQSQTGMISLTQQVSAVRLD----------------------- 100

  Fly   234 APWSHPRDTLTDSLYCDIPSSADESDAVSILNTHLKITEPFDCQTAPVYAKDIPKKGNLDSVVNL 298
               :|..||.            :::|.| :.||...::                  |:.|:::..
 Worm   101 ---THKSDTF------------EQNDLV-LDNTGAVLS------------------GSRDALIRR 131

  Fly   299 LINNNTKDL------RFAFLTTSRLFSPPHQLLSKII------AKIDNEE----------ENVLR 341
            |:  .|:|.      .|:.|...|.|..||:|:.||:      ...|:..          .::||
 Worm   132 LV--PTRDFCPDESYIFSLLVNIRTFISPHELMQKIVQYCMFAQNADSHNFAKEGRGRMFAHILR 194

  Fly   342 LLNEWLDTCPGDFSHELLLQELENKRNVKGLAAFLDGIPQALAQKDENGRSQLNNLL-------T 399
            |.:||....|.||                               |.|..|::||.||       |
 Worm   195 LCSEWATNIPYDF-------------------------------KTEYMRTRLNELLRLCAVDKT 228

  Fly   400 KQSSASSLGR--QSSIKSLKRF---AANVYKTDNVLNN--------------CSSAFELAHQLYA 445
            .|...:.|..  :||:..|.|:   .||:.|..:...|              |:.|..:|.||..
 Worm   229 YQQKTTELQSTLRSSLNKLDRYEKAVANLQKALSENTNLPEQSDSMTGLFVLCNDAKTVAQQLTH 293

  Fly   446 IEYAYLSQIRLEEFVEILEKDELKTC--ISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEI 508
            ||....|.:.::|.|:.|..|.|...  .|:.|.||:.|       |..|::|||:||...|.|:
 Worm   294 IEMERFSMVGVDEIVQSLASDPLSEIGRHSKNKEGTISS-------ISFYIEWFNRLSAFAAIEV 351

  Fly   509 LKLGKKSQRAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQTTKFEGLEHQ 573
            ||..||..|..:.:|.::.|.||...|||||:|||:..|:|.|::||||||.:|:..|.|.|:||
 Worm   352 LKQTKKRNRVAVFEFMIDIAKECCEIGNFNSMMAIVAGLSLPAVSRLKKTWCRVEKAKLEILQHQ 416

  Fly   574 MDPSSNFLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINESHETKLANGYINFEKC 638
            :|||.|||:||:|:|||.||::....|: ::.:||||.|.||||..|...|...|.|.::||...
 Worm   417 LDPSGNFLSYRATIKAAQWRADSARGNQ-QKIVIPFFVLLLKDLFLIYHGHPRILPNAHLNFMAF 480

  Fly   639 LHLGTQLRNFGKWQRLDCPYEQLPSVVSYLLKAEVLSEDLLMKASYESEPPETGEEKDHYKTLKA 703
            ..|..|||:..:|:...|.:|:.|.|:.|||...|..|...|..|:|.||||:..|:|.:|.||.
 Worm   481 NQLAEQLRDVIQWKSTVCTFEKNPQVLQYLLITSVSGEKDSMLMSFECEPPESSSERDQHKKLKG 545

  Fly   704 AR 705
            .:
 Worm   546 GK 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	23/98 (23%)
		RasGEF	438..638	CDD:279011	87/201 (43%)
R05G6.10	NP_001294201.1	RasGEFN	116..242	CDD:214571	35/176 (20%)
		RasGEF	279..532	CDD:214539	108/260 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165723
Domainoid	1	1.000	189	1.000	Domainoid score	I1946
eggNOG	1	0.900	-	-		E1_KOG3541
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I2165
Isobase	1	0.950	-	0	Normalized mean entropy	S3112
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246323at33208
OrthoFinder	1	1.000	-	-		FOG0001827
OrthoInspector	1	1.000	-	-		otm14078
orthoMCL	1	0.900	-	-		OOG6_104212
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1189
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.750