Protein Alignment CG4853 and RASGEF1B

DIOPT Version :9

• Sequence 1: NP_611222.2
• Gene: CG4853 / 36974
• FlyBaseID: FBgn0034230
• Length: 709
• Species: Drosophila melanogaster
• Sequence 2: NP_689758.1
• Gene: RASGEF1B / 153020
• HGNCID: 24881
• Length: 473
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 171/456 - (37%)
• Similarity: 268/456 - (58%)
• Gaps: 69/456 - (15%)

  Fly   290 GNLDSVVNLLINN----NTKDLRFAFLTTSRLFSPPHQLLSKI---------IAKIDNEEE---- 337
            |:|::::..|:.|    ..:...|.||.:||||..|::|::|:         ::..|:::.
Human    41 GSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRK 105

  Fly   338 ---NVLRLLNEWLDTCPGDFSHELLLQELEN-------------KRNVKGLAAFLDGIPQALAQK 386
               .:|:||.||.:|.|.||..|.:::.|::             ::||:.:...|.....||:|.
Human   106 IAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQY 170

  Fly   387 DENGRSQLNNLLTKQSSASSLGRQSSIK----SLKRFAANVYKTDNVLNNCSSAFELAHQLYAIE 447
            :|        :|.|.||.|: .|.:.:|    |::|         :::..|:..:.||.||..||
Human   171 EE--------VLAKISSTST-DRLTVLKTKPQSIQR---------DIITVCNDPYTLAQQLTHIE 217

  Fly   448 YAYLSQIRLEEFVE-ILEKDEL---KTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEI 508
            ...|:.|..||||: .::||.|   |:|.|:.|         ....:::||:|||:||||.||||
Human   218 LERLNYIGPEEFVQAFVQKDPLDNDKSCYSERK---------KTRNLEAYVEWFNRLSYLVATEI 273

  Fly   509 LKLGKKSQRAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQTTKFEGLEHQ 573
            ....||..||:||:::::.|.||||.|||||||||::.:|::.::|||||||||:|.||:.||||
Human   274 CMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQ 338

  Fly   574 MDPSSNFLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINESHETKLANGYINFEKC 638
            |||||||.|||:.::.|..||....::. |:.:||||||.:||::.:||....:|.||::||||.
Human   339 MDPSSNFYNYRTALRGAAQRSLTAHSSR-EKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKF 402

  Fly   639 LHLGTQLRNFGKWQRLDCPYEQLPSVVSYLLKAEVLSEDLLMKASYESEPPETGEEKDHYKTLKA 703
            ..|..|:..|..|::::||:|:...::.|||...|.|||.|..||||||.||...|||.:|:|::
Human   403 WELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRS 467

  Fly   704 A 704
            :
Human   468 S 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	26/94 (28%)
		RasGEF	438..638	CDD:279011	99/203 (49%)
RASGEF1B	NP_689758.1	REM	42..167	CDD:100121	28/124 (23%)
		RasGEF	209..403	CDD:395492	100/203 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157781
Domainoid	1	1.000	68	1.000	Domainoid score	I9711
eggNOG	1	0.900	-	-		E1_KOG3541
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3112
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246323at33208
OrthoFinder	1	1.000	-	-		FOG0001827
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104212
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1189
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.660