DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4853 and Rasgef1b

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	XP_017454916.1	Gene:	Rasgef1b / 100361238	RGDID:	1562220	Length:	543	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	195/577 - (33%)
Similarity:	309/577 - (53%)	Gaps:	101/577 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 ASLMSSSSAITGSDQVI-GSVSSTTIGDKSSNISSCDSGHDGLFHSVSM---------------S 233
            |:|:..:....||..:: |::.||..|:|||:....:.....:::|::.               |
  Rat     6 AALLGCTLRSKGSSPMLEGTIFSTLAGEKSSSDYKKEQQWKPVYYSLATMCLSNPLIEKPGGKES 70

  Fly   234 APWSHPRDTLTDSLYCDIPSSADESDAVSILNTHLKITEPFDCQTAPVYAKDIPKKGNLDSVVNL 298
            .|.:.|...:.||...:........|:...||.|                .:....|:|::::..
  Rat    71 MPQTPPFSAMFDSSGYNRNVYQPSEDSCGGLNYH----------------DNNLLSGSLEALIQH 119

  Fly   299 LINN----NTKDLRFAFLTTSRLFSPPHQLLSKI---------IAKIDNEEE-------NVLRLL 343
            |:.|    ..:...|.||.:||||..|::|::|:         :::.|.::.       .:|:||
  Rat   120 LVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCIEHQRLSEGDGDKNQTRKIAPKILQLL 184

  Fly   344 NEWLDTCPGDFSHELLLQELEN-------------KRNVKGLAAFLDGIPQALAQKDENGRSQLN 395
            .||.:|.|.||..|.:::.|::             ::||:.:...|.....||:|.:|
  Rat   185 TEWTETFPYDFRDERMMRNLKDLAHRMASGEEQTYRKNVQQMMQCLIRKLAALSQYEE------- 242

  Fly   396 NLLTKQSSASSLGRQSSIK----SLKRFAANVYKTDNVLNNCSSAFELAHQLYAIEYAYLSQIRL 456
             :|.|.||.:: .|.:.:|    |::|         :::..||..:.||.||..||...|:.|..
  Rat   243 -VLAKLSSTAT-DRLTVLKAKPQSIQR---------DIMTVCSDPYTLAQQLTHIELERLNYIGP 296

  Fly   457 EEFVE-ILEKDEL---KTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQR 517
            ||||: .::||.|   |.|.|:.|         ....:::||:|||:||||.||||....||..|
  Rat   297 EEFVQAFVQKDPLDNDKNCYSERK---------KTRNLEAYVEWFNRLSYLVATEICMPVKKKHR 352

  Fly   518 AQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQTTKFEGLEHQMDPSSNFLN 582
            |:||:::::.|.||||.|||||||||::.:|::.::|||||||||:|.||:.|||||||||||||
  Rat   353 ARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFLN 417

  Fly   583 YRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINESHETKLANGYINFEKCLHLGTQLRN 647
            ||:.::.|..||....::. |:.:||||||.:||::.:||....:|.||::||||...|..|:..
  Rat   418 YRTALRGAAQRSLTAHSSR-EKIVIPFFSLLIKDIYFLNEGCVNRLPNGHVNFEKFWELAKQVSE 481

  Fly   648 FGKWQRLDCPYEQLPSVVSYLLKAEVLSEDLLMKASYESEPPETGEEKDHYKTLKAA 704
            |..|::::||:|:...|:.|||...|.|||.|..||||||.||...|||.:|:|:|:
  Rat   482 FMTWKQVECPFERDRKVLQYLLSVPVFSEDALYLASYESEGPENNIEKDRWKSLRAS 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	26/96 (27%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	100/203 (49%)
Rasgef1b	XP_017454916.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351748
Domainoid	1	1.000	71	1.000	Domainoid score	I9203
eggNOG	1	0.900	-	-		E1_KOG3541
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246323at33208
OrthoFinder	1	1.000	-	-		FOG0001827
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104212
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1189
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.710