Protein Alignment CtsK2 and CTSF

DIOPT Version :10

• Sequence 1: NP_725686.1
• Gene: CtsK2 / 36973
• FlyBaseID: FBgn0034229
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_003784.2
• Gene: CTSF / 8722
• HGNCID: 2531
• Length: 484
• Species: Homo sapiens
• Alignment Length: 316
• Identity: 103/316 - (32%)
• Similarity: 155/316 - (49%)
• Gaps: 26/316 - (8%)

  Fly   112 FGDFLSQSGKTYLSAADRALHEGAFASTKNLVEAGN-AAFAQGVHTFKQAVNAFADLTHSEF--- 172
            |.:|:....:||.|..:.......|.:  |:|.|.. .|..:|  |.:..|..|:|||..||
Human   187 FKNFVITYNRTYESKEEARWRLSVFVN--NMVRAQKIQALDRG--TAQYGVTKFSDLTEEEFRTI 247

  Fly   173 -LSQLTGLKRSPEAKARAAASLKLVNLPAKPIPDAFDWREHGGVTPVKFQGTCGSCWAFATTGAI 236
             |:.|  |::.|..|.:.|.|:      ....|..:|||..|.||.||.||.|||||||:.||.:
Human   248 YLNTL--LRKEPGNKMKQAKSV------GDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSVTGNV 304

  Fly   237 EGHTFRKTGSLPNLSEQNLVDCGPVEDFGLNGCDGGFQEAAFCFIDEVQKGVSQEGAYPYIDNKG 301
            ||..|...|:|.:||||.|:||..::    ..|.||....|:..|..: .|:..|..|.|..:..
Human   305 EGQWFLNQGTLLSLSEQELLDCDKMD----KACMGGLPSNAYSAIKNL-GGLETEDDYSYQGHMQ 364

  Fly   302 TCKYDGSKSGATLQGFAAIPPKDEEQLKKVVATLGPVACSVNGLETLKNYAGGIYND--DECNKG 364
            :|.:...|:...:.....: .::|::|...:|..||::.::|.. .::.|..||...  ..|:..
Human   365 SCNFSAEKAKVYINDSVEL-SQNEQKLAAWLAKRGPISVAINAF-GMQFYRHGISRPLRPLCSPW 427

  Fly   365 EPNHSILVVGYGSEKGQDYWIVKNSWDDTWGEKGYFRLPRGKNYCFIAEECSYPVV 420
            ..:|::|:||||:.....:|.:||||...||||||:.|.||...|.:....|..||
Human   428 LIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAVV 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK2	NP_725686.1	Inhibitor_I29	112..172	CDD:462410	17/60 (28%)
		Peptidase_C1A	204..418	CDD:239068	75/215 (35%)
CTSF	NP_003784.2	Inhibitor_I29	187..243	CDD:214853	17/59 (29%)
		Peptidase_C1	271..482	CDD:425470	75/217 (35%)