Protein Alignment CtsK2 and TINAGL1

DIOPT Version :10

• Sequence 1: NP_725686.1
• Gene: CtsK2 / 36973
• FlyBaseID: FBgn0034229
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_071447.1
• Gene: TINAGL1 / 64129
• HGNCID: 19168
• Length: 467
• Species: Homo sapiens
• Alignment Length: 316
• Identity: 88/316 - (27%)
• Similarity: 126/316 - (39%)
• Gaps: 64/316 - (20%)

  Fly   143 VEAGNAAFAQGVHTFKQAVNAFADLTHSEFLSQLTGLKRSPEAKARAAASLKLVNLPAKPIPDAF 207
            :..||..:..|.|      :||..:|..|.:....|..| |.:.......:..|..|.:.:|.||
Human   150 INQGNYGWQAGNH------SAFWGMTLDEGIRYRLGTIR-PSSSVMNMHEIYTVLNPGEVLPTAF 207

  Fly   208 DWRE------HGGVTPVKFQGTCGSCWAFATTG-AIEGHTFRKTGSL-PNLSEQNLVDCGPVEDF 264
            :..|      |   .|:. ||.|...|||:|.. |.:..:....|.: |.||.|||:.|...:.
Human   208 EASEKWPNLIH---EPLD-QGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQ- 267

  Fly   265 GLNGCDGGFQEAAFCFIDEVQKGVSQEGAYPYI----DNKG---TCKYDGSKSG-ATLQGFAAIP 321
              .||.||..:.|:.|:.  ::||..:..||:.    |..|   .|.......| ...|..|..|
Human   268 --QGCRGGRLDGAWWFLR--RRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCP 328

  Fly   322 -------------------PKDEEQLKKVVATLGPVACSVNGLETLKNYAGGIYNDDECNKGEP- 366
                               ..|:|.:|:::.. |||...:...|....|.||||:....:.|.|
Human   329 NSYVNNNDIYQVTPVYRLGSNDKEIMKELMEN-GPVQALMEVHEDFFLYKGGIYSHTPVSLGRPE 392

  Fly   367 ------NHSILVVGYGSEKGQD-----YWIVKNSWDDTWGEKGYFRLPRGKNYCFI 411
                  .||:.:.|:|.|...|     ||...|||...|||:|:||:.||.|.|.|
Human   393 RYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDI 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK2	NP_725686.1	Inhibitor_I29	112..172	CDD:462410	7/28 (25%)
		Peptidase_C1A	204..418	CDD:239068	75/255 (29%)
TINAGL1	NP_071447.1	Somatomedin_B	54..94	CDD:470596
		VWC	105..>140	CDD:450195
		Peptidase_C1A_CathepsinB	204..455	CDD:239111	75/255 (29%)