Protein Alignment CtsK2 and Cts7

DIOPT Version :10

• Sequence 1: NP_725686.1
• Gene: CtsK2 / 36973
• FlyBaseID: FBgn0034229
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_062412.1
• Gene: Cts7 / 56092
• MGIID: 1860262
• Length: 331
• Species: Mus musculus
• Alignment Length: 335
• Identity: 117/335 - (34%)
• Similarity: 178/335 - (53%)
• Gaps: 27/335 - (8%)

  Fly    96 IAKAVPKVPLLSNVQDFGDFLSQSGKTYLSAAD---RALHEGAFASTK-NLVEAGNAAFAQGVHT 156
            :|.|.| .|..:...::.::...:.:||....:   ||:.||.....| :::|.|     ..::.
Mouse    14 VALAAP-APDYNLDAEWEEWKRSNDRTYSPEEEKQRRAVWEGNVKWIKQHIMENG-----LWMNN 72

  Fly   157 FKQAVNAFADLTHSEFLSQLTGLKRSPEAKARAAASLKLVNLPAKPIPDAFDWREHGGVTPVKFQ 221
            |...:|.|.|:|..|       :|...|:.:....:.|.:......||...|||:.|.||||:.|
Mouse    73 FTIEMNEFGDMTGEE-------MKMLTESSSYPLRNGKHIQKRNPKIPPTLDWRKEGYVTPVRRQ 130

  Fly   222 GTCGSCWAFATTGAIEGHTFRKTGSLPNLSEQNLVDCGPVEDFGLNGCDGGFQEAAFCFIDEVQK 286
            |:||:||||:.|..|||..|:|||.|..||.|||:||.  ..:|..|||||....||.::.. ..
Mouse   131 GSCGACWAFSVTACIEGQLFKKTGKLIPLSVQNLMDCS--VSYGTKGCDGGRPYDAFQYVKN-NG 192

  Fly   287 GVSQEGAYPYIDNKGTCKYDGSKSGATLQGFAAIPPKDEEQLKKVVATLGPVACSVNGLE-TLKN 350
            |:..|..|||......|:|...:|...:..|..: |::||.|.:.:.|.||:|.:::|.. :..:
Mouse   193 GLEAEATYPYEAKAKHCRYRPERSVVKVNRFFVV-PRNEEALLQALVTHGPIAVAIDGSHASFHS 256

  Fly   351 YAGGIYNDDECNKGEPNHSILVVGYGSE----KGQDYWIVKNSWDDTWGEKGYFRLPRGK-NYCF 410
            |.||||::.:|.|...:|.:|:||||.|    :.:.||::|||..:.|||.||.:||||: |||.
Mouse   257 YRGGIYHEPKCRKDTLDHGLLLVGYGYEGHESENRKYWLLKNSHGERWGENGYMKLPRGQNNYCG 321

  Fly   411 IAEECSYPVV 420
            ||....||.:
Mouse   322 IASYAMYPAL 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK2	NP_725686.1	Inhibitor_I29	112..172	CDD:462410	14/63 (22%)
		Peptidase_C1A	204..418	CDD:239068	92/219 (42%)
Cts7	NP_062412.1	Inhibitor_I29	29..87	CDD:214853	14/62 (23%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18776147	33..50		2/16 (13%)
		Peptidase_C1A	113..329	CDD:239068	92/219 (42%)