DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4847 and ctsz

DIOPT Version :9

Sequence 1:	NP_725686.1	Gene:	CG4847 / 36973	FlyBaseID:	FBgn0034229	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001006043.1	Gene:	ctsz / 450022	ZFINID:	ZDB-GENE-041010-139	Length:	301	Species:	Danio rerio

Alignment Length:	294	Identity:	84/294 - (28%)
Similarity:	124/294 - (42%)	Gaps:	82/294 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 LTGLKRSPEAKARAAASLKLVNLPAKPIPDAFDWREHGGVTPVK------FQGTCGSCWAFATTG 234
            |.|:|..|    |...|:.|     |.:|..:|||...||..|.      ....||||||..:|.
Zfish    36 LQGVKTGP----RPYESMNL-----KELPKEWDWRNIKGVNYVSTTRNQHIPQYCGSCWAHGSTS 91

  Fly   235 AIEGH-TFRKTGSLPN--LSEQNLVDCGPVEDFGLNGCDGGFQEAAFCFIDEVQKGVSQEGAYPY 296
            |:... ..::..:.|:  ||.||::|||   |.|  .|.||.....:.:..  .||:..|....|
Zfish    92 ALADRINIKRKAAWPSAYLSVQNVIDCG---DAG--SCSGGDHSGVWEYAH--NKGIPDETCNNY 149

  Fly   297 ---------IDNKGTC------------------KYDGSKSGATLQGFAAIPPKDEEQLKKVVAT 334
                     .:..|||                  .| ||.||.             :::|..:.:
Zfish   150 QAKDQDCKPFNQCGTCTTFGVCNIVKNFTLWKVGDY-GSASGL-------------DKMKAEIYS 200

  Fly   335 LGPVACSVNGLETLKNYAGGIYNDDECNKGEP--NHSILVVGYG-SEKGQDYWIVKNSWDDTWGE 396
            .||::|.:...:.|..|.||:|::   ...||  ||.:.|.|:| .|.|.::|:|:|||.:.|||
Zfish   201 GGPISCGIMATDKLDAYTGGLYSE---YVQEPYINHIVSVAGWGVDENGVEFWVVRNSWGEPWGE 262

  Fly   397 KGYFRL-------PRGKNY-CFIAEECSY--PVV 420
            ||:.|:       ..|..| ..|.|:|.|  |::
Zfish   263 KGWLRIVTSAYKGGSGSQYNLAIEEDCMYGDPIL 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4847	NP_725686.1	Inhibitor_I29	112..172	CDD:285458
CG4847	NP_725686.1	Peptidase_C1A	204..418	CDD:239068	75/262 (29%)
ctsz	NP_001006043.1	Peptidase_C1A_CathepsinX	54..295	CDD:239149	75/264 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820