Protein Alignment CtsK2 and Ctsc

DIOPT Version :10

• Sequence 1: NP_725686.1
• Gene: CtsK2 / 36973
• FlyBaseID: FBgn0034229
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_058793.1
• Gene: Ctsc / 25423
• RGDID: 2445
• Length: 462
• Species: Rattus norvegicus
• Alignment Length: 380
• Identity: 109/380 - (28%)
• Similarity: 160/380 - (42%)
• Gaps: 83/380 - (21%)

  Fly    74 GNNRVGGALQNVAGAVQNAVG-NIAKAVPKVPLLSNVQDFGDFLSQSGKTYLSAADRALHEGAFA 137
            |:..:....:.:.|.|.:.:| |.|..|.|           ...:.|.|.|::.|    |.|
  Rat   111 GSRAISYCHETMTGWVHDVLGRNWACFVGK-----------KMANHSEKVYVNVA----HLG--- 157

  Fly   138 STKNLVEAGNAAFAQGVHTFKQAVN----AFADLTHSEF--LSQLTGLKRSPEA----KARAAAS 192
               .|.|..:.......|.|.:|:|    ::...|:.|:  ||....::||..:    :.:.|..
  Rat   158 ---GLQEKYSERLYSHNHNFVKAINSVQKSWTATTYEEYEKLSIRDLIRRSGHSGRILRPKPAPI 219

  Fly   193 LKLVNLPAKPIPDAFDWREHGG---VTPVKFQGTCGSCWAFATTGAIEG--HTFRKTGSLPNLSE 252
            ...:......:|:::|||...|   |:||:.|.:||||::||:.|.:|.  .........|.||.
  Rat   220 TDEIQQQILSLPESWDWRNVRGINFVSPVRNQESCGSCYSFASLGMLEARIRILTNNSQTPILSP 284

  Fly   253 QNLVDCGPVEDFGLNGCDGGFQ-----EAAFCFIDEVQKGVSQEGAYPYIDNKGTCK-------- 304
            |.:|.|.|.    ..||||||.     :.|..|      ||.:|..:||......||
  Rat   285 QEVVSCSPY----AQGCDGGFPYLIAGKYAQDF------GVVEENCFPYTATDAPCKPKENCLRY 339

  Fly   305 ------YDGSKSGATLQGFAAIPPKDEEQLKKVVATLGPVACSVNGLETLKNYAGGIYN----DD 359
                  |.|...|..          :|..:|..:...||:|.:....:...:|..|||:    .|
  Rat   340 YSSEYYYVGGFYGGC----------NEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSD 394

  Fly   360 ECNKGE-PNHSILVVGYGSE--KGQDYWIVKNSWDDTWGEKGYFRLPRGKNYCFI 411
            ..|..| .||::|:||||.:  .|.|||||||||...|||.||||:.||.:.|.|
  Rat   395 PFNPFELTNHAVLLVGYGKDPVTGLDYWIVKNSWGSQWGESGYFRIRRGTDECAI 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK2	NP_725686.1	Inhibitor_I29	112..172	CDD:462410	13/63 (21%)
		Peptidase_C1A	204..418	CDD:239068	82/239 (34%)
Ctsc	NP_058793.1	CathepsinC_exc	25..138	CDD:462598	6/26 (23%)
		Pox_I6	168..>204	CDD:333259	8/35 (23%)
		Peptidase_C1A_CathepsinC	230..459	CDD:239112	82/240 (34%)