DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4847 and Ctsz

DIOPT Version :9

Sequence 1:	NP_725686.1	Gene:	CG4847 / 36973	FlyBaseID:	FBgn0034229	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_899159.1	Gene:	Ctsz / 252929	RGDID:	708479	Length:	306	Species:	Rattus norvegicus

Alignment Length:	254	Identity:	76/254 - (29%)
Similarity:	116/254 - (45%)	Gaps:	47/254 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 IPDAFDWREHGGVTPVKFQGT------CGSCWAFATTGAIEGH-TFRKTGSLPN--LSEQNLVDC 258
            :|..:|||...||........      ||||||..:|.|:... ..::.|:.|:  ||.||::||
  Rat    64 LPKNWDWRNVNGVNYASVTRNQHIPQYCGSCWAHGSTSALADRINIKRKGAWPSTLLSVQNVIDC 128

  Fly   259 GPVEDFGLNGCDGGFQEAAFCFIDEVQKGVSQEGAYPY---------IDNKGTCKYDGSKSGATL 314
            |     ....|:||.....:.:..  :.|:..|....|         .:..|||  ...|...|:
  Rat   129 G-----NAGSCEGGNDLPVWEYAH--KHGIPDETCNNYQAKDQECDKFNQCGTC--TEFKECHTI 184

  Fly   315 QGFAAIPPKD-------EEQLKKVVATLGPVACSVNGLETLKNYAGGIYNDDECNKGEPNHSILV 372
            |.:......|       |:.:.::.|. ||::|.:...|.:.||.||||.:.: |:...||.|.|
  Rat   185 QNYTLWRVGDYGSLSGREKMMAEIYAN-GPISCGIMATERMSNYTGGIYTEYQ-NQAIINHIISV 247

  Fly   373 VGYG-SEKGQDYWIVKNSWDDTWGEKGYFRL-------PRGKNYCFIAEE-CSY--PVV 420
            .|:| |..|.:||||:|||.:.|||:|:.|:       ..|.:|....|| |::  |:|
  Rat   248 AGWGVSNDGIEYWIVRNSWGEPWGERGWMRIVTSTYKGGTGSSYNLAIEEACTFGDPIV 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4847	NP_725686.1	Inhibitor_I29	112..172	CDD:285458
CG4847	NP_725686.1	Peptidase_C1A	204..418	CDD:239068	74/249 (30%)
Ctsz	NP_899159.1	Peptidase_C1A_CathepsinX	64..305	CDD:239149	74/251 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820