Protein Alignment CtsK2 and Y65B4A.2

DIOPT Version :10

• Sequence 1: NP_725686.1
• Gene: CtsK2 / 36973
• FlyBaseID: FBgn0034229
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_001293246.1
• Gene: Y65B4A.2 / 171655
• WormBaseID: WBGene00022026
• Length: 448
• Species: Caenorhabditis elegans
• Alignment Length: 339
• Identity: 75/339 - (22%)
• Similarity: 123/339 - (36%)
• Gaps: 107/339 - (31%)

  Fly   156 TFKQAVNAFADLTHS-------------EFLSQLTGLKRSPEAKARAAASLKLVNLPAKPIPDAF 207
            |:|...|.|.....|             |::.|   :::..|:.|......:|.|..:..:|..|
 Worm   108 TWKAKFNKFGVKNRSYGFKYTRNQTAVEEYVEQ---IRKFFESDAMKRHLDELENFNSSDVPKNF 169

  Fly   208 D----WREHGGVTPVKFQGTCGSCWAFATTG-AIEGHTFRKTGSLPN-LSEQNLVDCGPVEDFGL 266
            |    |.....::.|..||.||||:|.|..| |.:.......|:..: |||::::.|..|    .
 Worm   170 DARQKWPNCPSISNVPNQGGCGSCFAVAAAGVASDRACIHSNGTFKSLLSEEDIIGCCSV----C 230

  Fly   267 NGCDGGFQEAAFCFIDEVQKGV---SQEGAYPY-----------------IDNKGTC-------- 303
            ..|.||....|..:  .|.:|:   .::|..||                 .:.|.||
 Worm   231 GNCYGGDPLKALTY--WVNQGLVTGGRDGCRPYSFDLSCGVPCSPATFFEAEEKRTCMKRCQNIY 293

  Fly   304 ---KYDGSKSGATLQGFA--------AIPPKDEEQ--------------------------LKKV 331
               ||:..|..||   ||        .:.|..:|:                          :||.
 Worm   294 YQQKYEEDKHFAT---FAYSMYPRSMTVSPDGKERVKVPTIIGHFNDKKTEKLNVTEYRDIIKKE 355

  Fly   332 VATLGPVACSVNGLETLKNYAGGIYN-------DDECNKGEPNHSILVVGYG-SEKGQDYWIVKN 388
            :...||...:....|...:|:.|::.       ||.....   |.:.::|:| |:.|..||:..|
 Worm   356 ILLYGPTTMAFPVPEEFLHYSSGVFRPYPTDGFDDRIVYW---HVVRLIGWGESDDGTHYWLAVN 417

  Fly   389 SWDDTWGEKGYFRL 402
            |:.:.||:.|.|::
 Worm   418 SFGNHWGDNGLFKI 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK2	NP_725686.1	Inhibitor_I29	112..172	CDD:462410	5/28 (18%)
		Peptidase_C1A	204..418	CDD:239068	64/278 (23%)
Y65B4A.2	NP_001293246.1	Peptidase_C1A_CathepsinB	166..444	CDD:239111	64/278 (23%)