Protein Alignment CtsK2 and Ctsl

DIOPT Version :10

• Sequence 1: NP_725686.1
• Gene: CtsK2 / 36973
• FlyBaseID: FBgn0034229
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_034114.1
• Gene: Ctsl / 13039
• MGIID: 88564
• Length: 334
• Species: Mus musculus
• Alignment Length: 301
• Identity: 122/301 - (40%)
• Similarity: 172/301 - (57%)
• Gaps: 25/301 - (8%)

  Fly   129 RALHEGAFASTKN--LVEAGNAAFAQGVHTFKQAVNAFADLTHSEFLSQLTGLKRSPEAKARAAA 191
            ||:.|      ||  :::..|..::.|.|.|...:|||.|:|:.||...:.|.:.....|.|...
Mouse    49 RAIWE------KNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKKGRLFQ 107

  Fly   192 SLKLVNLPAKPIPDAFDWREHGGVTPVKFQGTCGSCWAFATTGAIEGHTFRKTGSLPNLSEQNLV 256
            ...::.     ||.:.||||.|.|||||.||.|||||||:.:|.:||..|.|||.|.:|||||||
Mouse   108 EPLMLK-----IPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLV 167

  Fly   257 DCGPVEDFGLNGCDGGFQEAAFCFIDEVQKGVSQEGAYPYIDNKGTCKYDGSKSGATLQGFAAIP 321
            ||...:  |..||:||..:.||.:|.| ..|:..|.:|||....|:|||....:.|...||..|
Mouse   168 DCSHAQ--GNQGCNGGLMDFAFQYIKE-NGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDI- 228

  Fly   322 PKDEEQLKKVVATLGPVACSVNGLE-TLKNYAGGIYNDDECNKGEPNHSILVVGYGSEKGQD--- 382
            |:.|:.|.|.|||:||::.:::... :|:.|:.|||.:..|:....:|.:|:||||.| |.|
Mouse   229 PQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYE-GTDSNK 292

  Fly   383 --YWIVKNSWDDTWGEKGYFRLPRGK-NYCFIAEECSYPVV 420
              ||:|||||...||.:||.::.:.: |:|.:|...|||||
Mouse   293 NKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK2	NP_725686.1	Inhibitor_I29	112..172	CDD:462410	14/44 (32%)
		Peptidase_C1A	204..418	CDD:239068	98/220 (45%)
Ctsl	NP_034114.1	Inhibitor_I29	29..87	CDD:214853	14/43 (33%)
		Peptidase_C1	114..332	CDD:425470	100/222 (45%)