Protein Alignment CtsK2 and Ctsc

DIOPT Version :10

• Sequence 1: NP_725686.1
• Gene: CtsK2 / 36973
• FlyBaseID: FBgn0034229
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_034112.3
• Gene: Ctsc / 13032
• MGIID: 109553
• Length: 462
• Species: Mus musculus
• Alignment Length: 381
• Identity: 101/381 - (26%)
• Similarity: 158/381 - (41%)
• Gaps: 85/381 - (22%)

  Fly    74 GNNRVGGALQNVAGAVQNAVGNIAKAVPKVPLLSNVQDFGDFLSQSGKTYLSAAD-RALHEGAFA 137
            |:..:....:.:.|.|.:.:|               :::..|:.:..::::...: .|.|.|...
Mouse   111 GHTAISYCHETMTGWVHDVLG---------------RNWACFVGKKVESHIEKVNMNAAHLGGLQ 160

  Fly   138 ST-KNLVEAGNAAFAQGVHTFKQAVNAFA----------DLTHSEFLSQLTGLKRSPEAKARAAA 191
            .. ...:...|..|.:.::|.:::..|.|          ||......||  .:.|...|......
Mouse   161 ERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQ--RIPRPKPAPMTDEI 223

  Fly   192 SLKLVNLPAKPIPDAFDWREHGG---VTPVKFQGTCGSCWAFATTGAIEG--HTFRKTGSLPNLS 251
            ..:::||     |:::|||...|   |:||:.|.:||||::||:.|.:|.  .........|.||
Mouse   224 QQQILNL-----PESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILS 283

  Fly   252 EQNLVDCGPVEDFGLNGCDGGFQ-----EAAFCFIDEVQKGVSQEGAYPYIDNKGTCK------- 304
            .|.:|.|.|.    ..||||||.     :.|..|      ||.:|..:||......||
Mouse   284 PQEVVSCSPY----AQGCDGGFPYLIAGKYAQDF------GVVEESCFPYTAKDSPCKPRENCLR 338

  Fly   305 -------YDGSKSGATLQGFAAIPPKDEEQLKKVVATLGPVACSVNGLETLKNYAGGIYN----D 358
                   |.|...|..          :|..:|..:...||:|.:....:...:|..|||:    .
Mouse   339 YYSSDYYYVGGFYGGC----------NEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLS 393

  Fly   359 DECNKGE-PNHSILVVGYGSE--KGQDYWIVKNSWDDTWGEKGYFRLPRGKNYCFI 411
            |..|..| .||::|:||||.:  .|.:|||:||||...|||.||||:.||.:.|.|
Mouse   394 DPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAI 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK2	NP_725686.1	Inhibitor_I29	112..172	CDD:462410	11/71 (15%)
		Peptidase_C1A	204..418	CDD:239068	80/239 (33%)
Ctsc	NP_034112.3	CathepsinC_exc	25..138	CDD:462598	4/41 (10%)
		Pox_I6	168..>204	CDD:333259	7/35 (20%)
		Peptidase_C1A_CathepsinC	230..459	CDD:239112	81/245 (33%)