DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4847 and CTSC

DIOPT Version :9

Sequence 1:	NP_725686.1	Gene:	CG4847 / 36973	FlyBaseID:	FBgn0034229	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001805.4	Gene:	CTSC / 1075	HGNCID:	2528	Length:	463	Species:	Homo sapiens

Alignment Length:	319	Identity:	96/319 - (30%)
Similarity:	138/319 - (43%)	Gaps:	66/319 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 ASTKNLVEAGNAAFAQGVHTFKQAVNA------------FADLTHSEFLSQLTG----LKRSPEA 185
            |..||..|..:....:..|.|.:|:||            :..||..:.:.:..|    :.|...|
Human   154 AHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPA 218

  Fly   186 KARAAASLKLVNLPAKPIPDAFDWRE-HG--GVTPVKFQGTCGSCWAFATTGAIEG--HTFRKTG 245
            ...|....|:::||.     ::|||. ||  .|:||:.|.:||||::||:.|.:|.  .......
Human   219 PLTAEIQQKILHLPT-----SWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNS 278

  Fly   246 SLPNLSEQNLVDCGPVEDFGLNGCDGGFQEAAFCFIDEVQK--GVSQEGAYPYIDNKGTCK---- 304
            ..|.||.|.:|.|...    ..||:|||   .:....:..:  |:.:|..:||......||
Human   279 QTPILSPQEVVSCSQY----AQGCEGGF---PYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKED 336

  Fly   305 ----------YDGSKSGATLQGFAAIPPKDEEQLKKVVATLGPVACSVNGLETLKNYAGGIYND- 358
                      |.|...|..          :|..:|..:...||:|.:....:...:|..|||:.
Human   337 CFRYYSSEYHYVGGFYGGC----------NEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHT 391

  Fly   359 ---DECNKGE-PNHSILVVGYG--SEKGQDYWIVKNSWDDTWGEKGYFRLPRGKNYCFI 411
               |..|..| .||::|:||||  |..|.|||||||||...|||.||||:.||.:.|.|
Human   392 GLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAI 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4847	NP_725686.1	Inhibitor_I29	112..172	CDD:285458	11/46 (24%)
CG4847	NP_725686.1	Peptidase_C1A	204..418	CDD:239068	78/236 (33%)
CTSC	NP_001805.4	CathepsinC_exc	26..138	CDD:312344
CTSC	NP_001805.4	Peptidase_C1A_CathepsinC	231..460	CDD:239112	80/242 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820