DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30103 and nt5e

DIOPT Version :9

Sequence 1:	NP_725682.2	Gene:	CG30103 / 36969	FlyBaseID:	FBgn0050103	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_957226.1	Gene:	nt5e / 393906	ZFINID:	ZDB-GENE-040426-1261	Length:	571	Species:	Danio rerio

Alignment Length:	562	Identity:	213/562 - (37%)
Similarity:	315/562 - (56%)	Gaps:	21/562 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SLILFF----LDWISGFKFTLLHTNDMHSRFDPISDTGGRCKTVDDAMGICFGGFGRVAEAVSAA 73
            :|:|.|    |.|.:.|:.|||||||:|:|.:..:...|:|....     ||.|..|.:..:...
Zfish     9 ALLLLFIHCQLCWSADFQLTLLHTNDVHARVEETNKDSGKCSKPP-----CFAGVSRRSTKIKEI 68

  Fly    74 RNTATDPVIYLNGGDSFQGTSWFSVYRGKMVARMLNFLAPDAMALGVHELDDGTDALAE-FLNTI 137
            |:...: |:.|:.||.||||.||:.|:|...|..:|.|..||||||.||.|:|.|.|.: ||..:
Zfish    69 RSKEKN-VLLLDAGDQFQGTVWFNYYKGAEAAYFMNQLKYDAMALGNHEFDNGVDGLLKPFLQEV 132

  Fly   138 TFPMVSSNINLINEPKLAENAN--LVTSLVITKGNRKIGIVGYIRPDTKERTQPS-NVIFKREVP 199
            ...::|:||..  :..||...:  .....:.|.|:.|:|:|||...:|...:.|. ::.|:.|:.
Zfish   133 NCTVLSANIKA--DETLAPRISGYYFPYKIFTLGSEKVGVVGYTSAETPALSLPGPHLKFEDEIT 195

  Fly   200 AINKETKKLKGQGIDIIIALGHSGYEKDMEIAKRCPDVDIVVGGQSHTFLYSGKAPSKEVSEGPY 264
            |:..:..||...|::.||||||||:..|..|||:...||:|:||.::||||:|..||.||..|||
Zfish   196 ALQPQVDKLLTLGVNKIIALGHSGFLMDQMIAKKVQGVDVVIGGHTNTFLYTGDPPSTEVPAGPY 260

  Fly   265 PTIVVKPDGRKVPVVQAYAYTKYLGNLSLEFDNGGNLLSFKGSPILLNNRFHPRKDVQDFLQLYR 329
            |.:|...|||:||||||||:.||||.|.:.||..||:|...|:|||||:...|..|:|..:..:|
Zfish   261 PLMVKSDDGRQVPVVQAYAFGKYLGFLKVTFDANGNVLESTGNPILLNSSVEPDPDIQAKVDSWR 325

  Fly   330 QVIDDMERHVVGTTSVYLNGDRKSCGYSECNFGNFIADSFVYARVVQTMADRSSWTDASIGLINA 394
            ..:.:.....||.|.|:|||..:.|.:.|||.||.|.|:.|:..:  ..||...|...|..::|.
Zfish   326 MNLANYSSQQVGQTLVFLNGTFEECRFRECNLGNLICDAMVHHNI--KYADELQWNHVSSCILNG 388

  Fly   395 GAIRASIDP-GETGAITEADVVTVLPFSQDLYYTRISGSQLMKALEHSAQMRSKHMTSAHLQVSG 458
            |.||..||. ...|:||..|::.||||.......:::||.|::|.|||.: |....|...|||||
Zfish   389 GGIRGPIDERNRNGSITMEDLIAVLPFGGTFDLVQLNGSTLLEAFEHSVR-RHGGNTGEFLQVSG 452

  Fly   459 LRLKFNHSLPKGERITEIRALCSDCQIPHYEAVDTNGYYGVVVTSFLLNGGEGYSFVDPKRPEVE 523
            .::.::.|...|.|:..::.||:.|::||||.:..|..|.||:.|:|::||:|::.:..|:.:.:
Zfish   453 FQVVYDLSKAPGSRVKSVKVLCTQCRVPHYEPLVPNKVYKVVLPSYLVDGGDGFTMIKEKKLKHD 517

  Fly   524 NMTILDRMAVIQYLQEHKVIYPEREDRQYVQHKHIANSGYMS 565
            :.. ||...|..|:.|.|.::|..|.|...........||.|
Zfish   518 SGD-LDISVVAGYISERKRVHPAVEGRFQFSSSCAGLRGYTS 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30103	NP_725682.2	UshA	25..555	CDD:223808	205/534 (38%)
		MPP_CD73_N	27..311	CDD:277354	120/287 (42%)
		5_nucleotid_C	339..511	CDD:280945	66/172 (38%)
nt5e	NP_957226.1	UshA	23..525	CDD:223808	198/513 (39%)
		MPP_CD73_N	27..307	CDD:277354	120/287 (42%)
		5_nucleotid_C	335..505	CDD:280945	66/172 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594713
Domainoid	1	1.000	159	1.000	Domainoid score	I4048
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1830
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	1	1.000	-	-		otm26617
orthoMCL	1	0.900	-	-		OOG6_101038
Panther	1	1.100	-	-	O	PTHR11575
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810