DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30103 and CG42249

DIOPT Version :9

Sequence 1:	NP_725682.2	Gene:	CG30103 / 36969	FlyBaseID:	FBgn0050103	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001259438.1	Gene:	CG42249 / 32043	FlyBaseID:	FBgn0259101	Length:	558	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	183/546 - (33%)
Similarity:	280/546 - (51%)	Gaps:	38/546 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GFKFTLLHTNDMHSRFDPISDTGGRCKTVDDAMGICFGGFGRVAEAVS--AARNTATDPVIYLNG 86
            ||...::|.||:|:||:....:||.|...::    |.||:.|....|.  .......:| ||:|.
  Fly    33 GFPVAIIHINDLHARFEATDTSGGTCDEGEE----CIGGYPRTVYTVKRLLQEQAELNP-IYINA 92

  Fly    87 GDSFQGTSWFSVYRGKMVARMLNFLAPDAMALGVHELDDGTDALAEFLNTITFPMVSSNINLINE 151
            |||||||.|:::.|..:..::||.|..|.|.||.||.|.|.:.:..||.|:...|:.:|::..:|
  Fly    93 GDSFQGTLWYNIGRWNVTQQLLNLLPADVMTLGNHEFDHGVEGVVPFLETVDTNMLVANMDCAHE 157

  Fly   152 PKLAENANLVTSLVITKGNRKIGIVGYIRPDTKERTQPSNVIFKREVPAINKETKKLKGQGIDII 216
            |.:....|  .|::|.:..||||::|.|...|.:......|||:.|...|.:|.:.||.||.:||
  Fly   158 PTMEGKYN--KSMIIERSGRKIGVIGVILETTYDLANTGKVIFRNESDTIREEAQLLKAQGANII 220

  Fly   217 IALGHSGYEKDMEIAKRCPD-VDIVVGGQSHTFLYSGKAPSKEVSEGPYPTIVVKPDGRKVPVVQ 280
            |.:.|.||:.|.:||....| :|::||..||||||:|..|......|.|||.|:...|.:|.:||
  Fly   221 IVVSHCGYDVDQQIAANAGDWIDVIVGSHSHTFLYTGDPPGPHTPSGDYPTEVIHSSGHRVLIVQ 285

  Fly   281 AYAYTKYLGNLSLEFDNGGNLLSFKGSPILLNNRFHPRKDVQDFLQL---YRQVIDDMERHVVGT 342
            |.||.:|:|||.:.||:.|::|.::|.|:.::... |..|:  .||.   ::..:..:....||.
  Fly   286 ASAYARYVGNLIVYFDDNGDVLDYEGDPLYMDQSV-PEDDI--VLQAMVPWQLEMKPIAERTVGQ 347

  Fly   343 TSVYLNGDRKSCGYSECNFGNFIADSFVYARVVQ-TMADRSSWTDASIGLINAGAIRASIDPGET 406
            :.|  |..:..|...|||.|||..|:.::|.|.. :.:...||::.:|.|.:.|..|..|..|.
  Fly   348 SRV--NLQQSQCSSGECNLGNFFTDAMLHAFVKDASSSSEESWSNVTIALTSTGTFRVPIPAGN- 409

  Fly   407 GAITEADVVTVLPFSQDLYYTRISGSQLMKALEH--------SAQMRSKHMTSAHLQVSGLRLKF 463
              ||...:..:.|:...|....:.|..:::.|||        ||..||    |..|||||||:::
  Fly   410 --ITYKQLFAMCPWQNRLVTLSLRGKHIVELLEHVVAPMNASSATPRS----SRFLQVSGLRIRY 468

  Fly   464 NHSLPKGERITEIRALCSDCQIPHYEAVDTNGYYGVVVTSFLLNGGEGYSFVDPKRPEVENMTIL 528
            :  |...:|:..:|..||.|.:|.|..:|....|.|||..:|.||..|:|.:.....:.| ....
  Fly   469 D--LNADQRVFSVRVRCSKCLVPRYIPLDLEHKYRVVVMEYLANGKNGFSVISENAEDPE-FGPF 530

  Fly   529 DRMAVIQYLQEHKVIYPEREDR-QYV 553
            |..|::.|:.....|....|.| |:|
  Fly   531 DLDALMDYMNSTGPITTAIEQRIQFV 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30103	NP_725682.2	UshA	25..555	CDD:223808	182/545 (33%)
		MPP_CD73_N	27..311	CDD:277354	108/286 (38%)
		5_nucleotid_C	339..511	CDD:280945	58/180 (32%)
CG42249	NP_001259438.1	UshA	26..547	CDD:223808	179/535 (33%)
		MPP_CD73_N	36..316	CDD:277354	108/286 (38%)
		5_nucleotid_C	345..514	CDD:280945	58/179 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468528
Domainoid	1	1.000	68	1.000	Domainoid score	I523
eggNOG	1	0.900	-	-		E1_COG0737
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I254
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	1	1.000	-	-		otm51348
orthoMCL	1	0.900	-	-		OOG6_101038
Panther	1	1.100	-	-	P	PTHR11575
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1114
	11	10.800