DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment veil and NT5E

DIOPT Version :9

Sequence 1:	NP_001286533.1	Gene:	veil / 36968	FlyBaseID:	FBgn0034225	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_002517.1	Gene:	NT5E / 4907	HGNCID:	8021	Length:	574	Species:	Homo sapiens

Alignment Length:	577	Identity:	230/577 - (39%)
Similarity:	327/577 - (56%)	Gaps:	42/577 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AAEFIILHNNDMHARFEQTSVTSGTCSKEEANTDQCYGGFARVAYEVRKYRKEAEEGGTPVFYLN 98
            |.|..|||.||:|:|.||||..|..|    .|..:|.||.||:..:|::.|: ||..   |..|:
Human    26 AWELTILHTNDVHSRLEQTSEDSSKC----VNASRCMGGVARLFTKVQQIRR-AEPN---VLLLD 82

  Fly    99 AGDTYTGTAWFTVYKDKIASAFLNKLSPDAISLGNHEFDQNVEGLV-PFLNAVEFPVLACNLNLT 162
            |||.|.||.||||||....:.|:|.|..||::|||||||..||||: |.|...:||:|:.|:.
Human    83 AGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIK-- 145

  Fly   163 DVPEMAAAKQLAN----STILERNGVKVGVIGYLTPDTKVLAF-RNKVEYEEEIVSINAEAAKLK 222
              .:...|.|::.    ..:|......||::||.:.:|..|:. ...:.:|:||.::..|..|||
Human   146 --AKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLK 208

  Fly   223 AQGINIIIALGHSGYQKDQEIAMNCPEVDIVIGGHSHTFLDANQPVADPTDSDPEAVRGPYPTTV 287
            ...:|.||||||||::.|:.||.....||:|:||||:|||....|   |:...|   .|.||..|
Human   209 TLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNP---PSKEVP---AGKYPFIV 267

  Fly   288 VQASGKKVPVVQAYAYTKYLGKIHVQFDAEGNLIEFDGAPILLNASVAQEQDLLDLLDEYRPKLD 352
            ....|:|||||||||:.||||.:.::||..||:|...|.|||||:|:.::..:...::::|.|||
Human   268 TSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLD 332

  Fly   353 ELENTVLGYTKVFLEGGN-ICRMRECNLGNLVTDAMIYSRVLENKGGEFWTDTAIAFMQGGGIRG 416
            ......||.|.|:|:|.: .||.||||:|||:.||||.:. |.:....||...::..:.|||||.
Human   333 NYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNN-LRHTDEMFWNHVSMCILNGGGIRS 396

  Fly   417 SVDKKDDGVINGATLLAVLPFENNLYVTRILGSTLLAALEHSASVRLQDSNGGFLQMSGLRVVYN 481
            .:|::::|.|....|.|||||.....:.::.||||..|.|||.. |...|.|.|||:.|:.|||:
Human   397 PIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVH-RYGQSTGEFLQVGGIHVVYD 460

  Fly   482 YNNEQGKRVVSAQALCASCAVPTYKSINETALYQVIVPQFLLEGGDGYTLIEESDPFTESMQRN- 545
            .:.:.|.|||....||..|.||:|..:....:|:||:|.||..||||:.:|::     |.::.:
Human   461 LSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKD-----ELLRHDS 520

  Fly   546 ---DLNATMEYLKQRHFVYPEIEERIVIHEKADTGSASGIVASISLLLLSSLLTRFI 599
               |:|....|:.:...:||.:|.||    |..|||...  .|.||:.||.....|:
Human   521 GDQDINVVSTYISKMKVIYPAVEGRI----KFSTGSHCH--GSFSLIFLSLWAVIFV 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
veil	NP_001286533.1	UshA	14..556	CDD:223808	215/532 (40%)
		MPP_CD73_N	37..330	CDD:277354	126/298 (42%)
		5_nucleotid_C	358..528	CDD:280945	72/170 (42%)
NT5E	NP_002517.1	UshA	11..532	CDD:223808	214/530 (40%)
		MPP_CD73_N	29..310	CDD:277354	126/298 (42%)
		5_nucleotid_C	339..507	CDD:280945	72/169 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158760
Domainoid	1	1.000	160	1.000	Domainoid score	I4045
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1895
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1945
Isobase	1	0.950	-	0	Normalized mean entropy	S6498
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	1	1.000	-	-		otm40520
orthoMCL	1	0.900	-	-		OOG6_101038
Panther	1	1.100	-	-	O	PTHR11575
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720