DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment veil and nt5e

DIOPT Version :9

Sequence 1:	NP_001286533.1	Gene:	veil / 36968	FlyBaseID:	FBgn0034225	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_957226.1	Gene:	nt5e / 393906	ZFINID:	ZDB-GENE-040426-1261	Length:	571	Species:	Danio rerio

Alignment Length:	592	Identity:	229/592 - (38%)
Similarity:	332/592 - (56%)	Gaps:	53/592 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLALLIHPVQPNPIAPRAEV--AAEF--IILHNNDMHARFEQTSVTSGTCSKEEANTDQCYGGFA 74
            ||.|.||          .::  :|:|  .:||.||:|||.|:|:..||.|||     ..|:.|.:
Zfish    10 LLLLFIH----------CQLCWSADFQLTLLHTNDVHARVEETNKDSGKCSK-----PPCFAGVS 59

  Fly    75 RVAYEVRKYRKEAEEGGTPVFYLNAGDTYTGTAWFTVYKDKIASAFLNKLSPDAISLGNHEFDQN 139
            |.:.::::.|.:.:.    |..|:|||.:.||.||..||...|:.|:|:|..||::|||||||..
Zfish    60 RRSTKIKEIRSKEKN----VLLLDAGDQFQGTVWFNYYKGAEAAYFMNQLKYDAMALGNHEFDNG 120

  Fly   140 VEGLV-PFLNAVEFPVLACNLNLTDVPEMAAAKQLANSTILERNGVKVGVIGYLTPDTKVLAFRN 203
            |:||: |||..|...||:.|:...:......:.......|......||||:||.:.:|..|:...
Zfish   121 VDGLLKPFLQEVNCTVLSANIKADETLAPRISGYYFPYKIFTLGSEKVGVVGYTSAETPALSLPG 185

  Fly   204 -KVEYEEEIVSINAEAAKLKAQGINIIIALGHSGYQKDQEIAMNCPEVDIVIGGHSHTFLDANQP 267
             .:::|:||.::..:..||...|:|.||||||||:..||.||.....||:|||||::|||....|
Zfish   186 PHLKFEDEITALQPQVDKLLTLGVNKIIALGHSGFLMDQMIAKKVQGVDVVIGGHTNTFLYTGDP 250

  Fly   268 VADPTDSDPEAVRGPYPTTVVQASGKKVPVVQAYAYTKYLGKIHVQFDAEGNLIEFDGAPILLNA 332
               |:...|   .||||..|....|::||||||||:.||||.:.|.|||.||::|..|.|||||:
Zfish   251 ---PSTEVP---AGPYPLMVKSDDGRQVPVVQAYAFGKYLGFLKVTFDANGNVLESTGNPILLNS 309

  Fly   333 SVAQEQDLLDLLDEYRPKLDELENTVLGYTKVFLEGG-NICRMRECNLGNLVTDAMI-----YSR 391
            ||..:.|:...:|.:|..|....:..:|.|.|||.|. ..||.||||||||:.|||:     |:.
Zfish   310 SVEPDPDIQAKVDSWRMNLANYSSQQVGQTLVFLNGTFEECRFRECNLGNLICDAMVHHNIKYAD 374

  Fly   392 VLENKGGEFWTDTAIAFMQGGGIRGSVDKKD-DGVINGATLLAVLPFENNLYVTRILGSTLLAAL 455
            .|:      |...:...:.||||||.:|::: :|.|....|:|||||.....:.::.|||||.|.
Zfish   375 ELQ------WNHVSSCILNGGGIRGPIDERNRNGSITMEDLIAVLPFGGTFDLVQLNGSTLLEAF 433

  Fly   456 EHSASVRLQDSN-GGFLQMSGLRVVYNYNNEQGKRVVSAQALCASCAVPTYKSINETALYQVIVP 519
            ||  |||....| |.|||:||.:|||:.:...|.||.|.:.||..|.||.|:.:....:|:|::|
Zfish   434 EH--SVRRHGGNTGEFLQVSGFQVVYDLSKAPGSRVKSVKVLCTQCRVPHYEPLVPNKVYKVVLP 496

  Fly   520 QFLLEGGDGYTLIEESDPFTESMQRNDLNATMEYLKQRHFVYPEIEERIVIHEKADTGSASGIVA 584
            .:|::||||:|:|:|.....:|... |::....|:.:|..|:|.:|.|...     :.|.:|:..
Zfish   497 SYLVDGGDGFTMIKEKKLKHDSGDL-DISVVAGYISERKRVHPAVEGRFQF-----SSSCAGLRG 555

  Fly   585 SISLLLL 591
            ..|.:||
Zfish   556 YTSTVLL 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
veil	NP_001286533.1	UshA	14..556	CDD:223808	219/555 (39%)
		MPP_CD73_N	37..330	CDD:277354	122/296 (41%)
		5_nucleotid_C	358..528	CDD:280945	74/177 (42%)
nt5e	NP_957226.1	UshA	23..525	CDD:223808	213/525 (41%)
		MPP_CD73_N	27..307	CDD:277354	121/294 (41%)
		5_nucleotid_C	335..505	CDD:280945	74/177 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594712
Domainoid	1	1.000	159	1.000	Domainoid score	I4048
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1895
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1830
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	1	1.000	-	-		otm26617
orthoMCL	1	0.900	-	-		OOG6_101038
Panther	1	1.100	-	-	O	PTHR11575
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5252
SonicParanoid	1	1.000	-	-		X1114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840