DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment veil and nt5e

DIOPT Version :9

Sequence 1:	NP_001286533.1	Gene:	veil / 36968	FlyBaseID:	FBgn0034225	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	XP_002933973.1	Gene:	nt5e / 100489347	XenbaseID:	XB-GENE-984211	Length:	578	Species:	Xenopus tropicalis

Alignment Length:	580	Identity:	219/580 - (37%)
Similarity:	334/580 - (57%)	Gaps:	49/580 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EFIILHNNDMHARFEQTSVTSGTCSKEEANTDQCYGGFARVAYEVRKYRKEAEEGGTPVFYLNAG 100
            :..|||.||:|||.|||:..||.|    .:...||||.||...::.:.|.....    |..|:||
Frog    24 QLTILHTNDVHARVEQTNRDSGKC----GDPQDCYGGVARRFAKIEEIRSTHRH----VLLLDAG 80

  Fly   101 DTYTGTAWFTVYKDKIASAFLNKLSPDAISLGNHEFDQNVEGLV-PFLNAVEFPVLACNLNLTDV 164
            |.|.||.||..||...|:.|:|.|..||::|||||||..|.||: |||..|:||:|:.|:.
Frog    81 DQYQGTIWFNYYKGHEAAYFMNYLKYDAMALGNHEFDNGVSGLLSPFLQEVKFPILSANIK---- 141

  Fly   165 PEMAAAKQLA-NST-------ILERNGVKVGVIGYLTPDTKVLAFRN-KVEYEEEIVSINAEAAK 220
                :.|||| |.|       |||....|:|||||.:.:|.||:... .:.:|:|::::..:..|
Frog   142 ----SDKQLAPNITGYYLPYKILEVGTEKIGVIGYSSRETPVLSNSGPHLVFEDEVLALQPQVDK 202

  Fly   221 LKAQGINIIIALGHSGYQKDQEIAMNCPEVDIVIGGHSHTFLDANQPVADPTDSDPEAVRGPYPT 285
            |...|:|.||||||||::.|:.||.....:|:|:|||::|||....|   |::..|.   |.||.
Frog   203 LLTLGVNKIIALGHSGFETDKLIAQKVKGIDVVVGGHTNTFLYTGPP---PSNDVPV---GEYPF 261

  Fly   286 TVVQASGKKVPVVQAYAYTKYLGKIHVQFDAEGNLIEFDGAPILLNASVAQEQDLLDLLDEYRPK 350
            :|:...|:.||||||||:.||||.:::.||.:|.::...|.||||:.|:.::..||..:::::..
Frog   262 SVMSDDGRSVPVVQAYAFGKYLGYLNITFDEQGTVVHSFGNPILLDRSIPEDATLLGEVNQWKEA 326

  Fly   351 LDELENTVLGYTKVFLEGGNI-CRMRECNLGNLVTDAMIYSRVLENKGGEFWTDTAIAFMQGGGI 414
            :....:..:|.|.|:|.|.:: ||.||||:|||:.||||.:.: .:.....|...::..:.||||
Frog   327 IRNYSSQPIGKTLVYLNGSSLECRNRECNMGNLICDAMIDNNI-RHPDEVRWNHVSLCILNGGGI 390

  Fly   415 RGSVDKK-DDGVINGATLLAVLPFENNLYVTRILGSTLLAALEHSASVRLQDSNGGFLQMSGLRV 478
            |.::|:: .:|.|....|::|||||....:..|.||||.:|.|||.. |.....|.|||:.|::|
Frog   391 RAAIDERISNGTITTEDLISVLPFEGTFDLIEIKGSTLKSAFEHSVH-RYGSGTGEFLQVGGIKV 454

  Fly   479 VYNYNNEQGKRVVSAQALCASCAVPTYKSINETALYQVIVPQFLLEGGDGYTLIEESDPFTESMQ 543
            |::.....|:|||..:.:|..|.||.|..:....:|:|::|.::..||||::::::     ||::
Frog   455 VFDTEKSPGQRVVKLEVICTECRVPKYVPVEMDKIYKVVLPSYIAAGGDGFSMLKD-----ESLK 514

  Fly   544 RN----DLNATMEYLKQRHFVYPEIEERIVI-HEKADTGSASGIVAS---ISLLLLSSLL 595
            .:    ||.....|:.||..|||.:|.||.. :|.:..|:....:.|   :|||.|.:||
Frog   515 HDSGDTDLTVVSNYIAQRQRVYPAVEGRITFTNEDSPNGATHTCLGSFPLVSLLTLFALL 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
veil	NP_001286533.1	UshA	14..556	CDD:223808	202/535 (38%)
		MPP_CD73_N	37..330	CDD:277354	126/302 (42%)
		5_nucleotid_C	358..528	CDD:280945	64/171 (37%)
nt5e	XP_002933973.1	MPP_CD73_N	25..306	CDD:277354	126/302 (42%)
nt5e	XP_002933973.1	5_nucleotid_C	334..510	CDD:376948	66/177 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3915
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1895
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1876
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	1	1.000	-	-		otm47705
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060