DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qkr54B and Khdrbs3

DIOPT Version :9

Sequence 1:	NP_001261050.1	Gene:	qkr54B / 36966	FlyBaseID:	FBgn0022987	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_071585.2	Gene:	Khdrbs3 / 64015	RGDID:	620921	Length:	346	Species:	Rattus norvegicus

Alignment Length:	310	Identity:	137/310 - (44%)
Similarity:	181/310 - (58%)	Gaps:	37/310 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EYIRDCMAERNRMDRKFPIAEKLLEGEIEKVQTTGRIPSREQKYADIYREKPLRISQRVLVPIRE 131
            :|:.:.|||::.:|..|..|.:|:..||||.| .|.... |:||.|:...|.:::.|:||:|:::
  Rat     4 KYLPELMAEKDSLDPSFTHALRLVNREIEKFQ-KGEAKD-EEKYIDVVINKNMKLGQKVLIPVKQ 66

  Fly   132 HPKFNFVGKLLGPKGNSLRRLQEETLCKMTVLGRNSMRDRVKEEELRSSKDPKYAHLNSDLHVEI 196
            .||||||||||||:||||:|||||||.||::||:.||||:.||||||.|.:.||.|||.||||.|
  Rat    67 FPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLI 131

  Fly   197 STIAPPAEAYARIAYAMAELRKYLIPDSNDIIRQEQLRELMDSTSLN-DNDNAKSGY---KKTSH 257
            ...|||||||||:.:|:.|::|:||||.||.|||.||:||   |.|| .::||....   |.|..
  Rat   132 EVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQEL---TYLNGGSENADVPVVRGKSTLR 193

  Fly   258 MQGGNNVL-----GGGSINPIG-GVKN---TPHHSYRSSQPSSFSKNVLAPKQKVM---SILEKA 310
            .:|.....     ||.:..|:. ||..   ||.....:..|.|..:.:|.|:.:.:   ......
  Rat   194 TRGVTTPAITRGRGGVTARPVAVGVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPP 258

  Fly   311 RTAMDETYGR-GYDDG--LGYDPHQSYDSY--SYGT----------HGHG 345
            .....||||. .||||  ..|| .||||||  ||.|          :|||
  Rat   259 PPPTQETYGEYDYDDGYSTAYD-DQSYDSYDNSYSTPAQSGADYYDYGHG 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr54B	NP_001261050.1	Qua1	68..117	CDD:292891	18/48 (38%)
qkr54B	NP_001261050.1	SF1_like-KH	122..237	CDD:239088	76/114 (67%)
Khdrbs3	NP_071585.2	Involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:O75525	1..160		87/157 (55%)
		Qua1	4..53	CDD:406639	18/50 (36%)
		KH-I_KHDRBS3	48..160	CDD:411898	69/111 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..268		12/55 (22%)
		Sam68-YY	266..320	CDD:406871	20/43 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348919
Domainoid	1	1.000	90	1.000	Domainoid score	I7586
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4780
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8931
orthoMCL	1	0.900	-	-		OOG6_110428
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1163
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.710