DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qkr54B and Khdrbs2

DIOPT Version :9

Sequence 1:	NP_001261050.1	Gene:	qkr54B / 36966	FlyBaseID:	FBgn0022987	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_579852.1	Gene:	Khdrbs2 / 170843	RGDID:	621738	Length:	349	Species:	Rattus norvegicus

Alignment Length:	370	Identity:	138/370 - (37%)
Similarity:	196/370 - (52%)	Gaps:	81/370 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EYIRDCMAERNRMDRKFPIAEKLLEGEIEKVQ-TTGRIPSREQKYADIYREKPLRISQRVLVPIR 130
            :|:.:.|||::.:|..|..|.:||..||||.| :.||....|:||.|:...|.:::|:|||:|::
  Rat     5 KYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGRKEDEEKKYLDVISNKNIKLSERVLIPVK 69

  Fly   131 EHPKFNFVGKLLGPKGNSLRRLQEETLCKMTVLGRNSMRDRVKEEELRSSKDPKYAHLNSDLHVE 195
            ::||||||||||||:||||:||||||..||::||:.||||:.||||||.|.:.|||||:.:|||.
  Rat    70 QYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVL 134

  Fly   196 ISTIAPPAEAYARIAYAMAELRKYLIPDSNDIIRQEQLRELMDSTSLNDNDNAKSG--------- 251
            |...|||.|||:|:::|:.|::|:|:||.||.|||||||||   :.||.::.:..|
  Rat   135 IEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLREL---SYLNGSEESGRGRGIRGRGIR 196

  Fly   252 YKKTSHMQGGNNVL------GGGSINPIGGVKNTPHHSYRSSQP-SSFSKNVLAPKQKVMSILEK 309
            ...|:..:|....:      |.|.:.|.|....      |.:.| ...::.|..|:.:..:.:..
  Rat   197 ITPTAPSRGRGGAVPPPPPPGRGVLTPRGTTVT------RGALPVPPVARGVPTPRARGTAAVPG 255

  Fly   310 ART---AMDETYGR-GYDDGLG--YDPHQSYDSY--SYGT----------HGHGPH--------- 347
            .|.   ...|.|.. |||||.|  || .|:|::|  ||.|          :|||.:
  Rat   256 YRAPPPPAPEAYEEYGYDDGYGGEYD-DQTYEAYDNSYVTPTQSVPEYYDYGHGVNEDAYDSYAP 319

  Fly   348 -----------GPPANILGGVGGISGGGGRGGHYESSDYEPDYGR 381
                       .||..           ..|||:.|.     .|||
  Rat   320 EEWTTTRSSLKAPPPR-----------SARGGYREH-----PYGR 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr54B	NP_001261050.1	Qua1	68..117	CDD:292891	20/49 (41%)
qkr54B	NP_001261050.1	SF1_like-KH	122..237	CDD:239088	74/114 (65%)
Khdrbs2	NP_579852.1	Qua1	6..57	CDD:292891	20/50 (40%)
		SF1_like-KH	61..180	CDD:239088	76/121 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..263		12/87 (14%)
		Sam68-YY	271..321	CDD:293176	17/50 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..349		9/45 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348927
Domainoid	1	1.000	90	1.000	Domainoid score	I7586
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8931
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11208
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1163
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.810