DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qkr54B and Khdrbs3

DIOPT Version :9

Sequence 1:	NP_001261050.1	Gene:	qkr54B / 36966	FlyBaseID:	FBgn0022987	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_034288.2	Gene:	Khdrbs3 / 13992	MGIID:	1313312	Length:	346	Species:	Mus musculus

Alignment Length:	340	Identity:	144/340 - (42%)
Similarity:	190/340 - (55%)	Gaps:	44/340 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EYIRDCMAERNRMDRKFPIAEKLLEGEIEKVQT-TGRIPSREQKYADIYREKPLRISQRVLVPIR 130
            :|:.:.|||::.:|..|..|.:|:..||||.|. .|:   .|:||.|:...|.:::.|:||:|::
Mouse     4 KYLPELMAEKDSLDPSFTHALRLVNREIEKFQKGEGK---EEEKYIDVVINKNMKLGQKVLIPVK 65

  Fly   131 EHPKFNFVGKLLGPKGNSLRRLQEETLCKMTVLGRNSMRDRVKEEELRSSKDPKYAHLNSDLHVE 195
            :.||||||||||||:||||:|||||||.||::||:.||||:.||||||.|.:.||.|||.||||.
Mouse    66 QFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVL 130

  Fly   196 ISTIAPPAEAYARIAYAMAELRKYLIPDSNDIIRQEQLRELMDSTSLN-DNDNAKSGY---KKTS 256
            |...|||||||||:.:|:.|::|:||||.||.|||.||:||   |.|| .::||....   |.|.
Mouse   131 IEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQEL---TYLNGGSENADVPVVRGKSTL 192

  Fly   257 HMQGGNNVL-----GGGSINPIG-GVKN---TPHHSYRSSQPSSFSKNVLAPKQKVM---SILEK 309
            ..:|.....     ||.:..|:. ||..   ||.....:..|.|..:.:|.|:.:.:   .....
Mouse   193 RTRGVTTPAITRGRGGVTARPVAVGVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPP 257

  Fly   310 ARTAMDETYGR-GYDDGLG--YDPHQSYDSY--SYGTHGHGPHGPPANILGGVGGISGGGGRGGH 369
            ......||||. .||||.|  || .||||||  ||.|        ||.........       ||
Mouse   258 PPPPTQETYGEYDYDDGYGTAYD-EQSYDSYDNSYST--------PAQSAADYYDY-------GH 306

  Fly   370 YESSDYEPDYGRREY 384
            ..|.|....||:.|:
Mouse   307 GLSEDAYDSYGQEEW 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr54B	NP_001261050.1	Qua1	68..117	CDD:292891	18/49 (37%)
qkr54B	NP_001261050.1	SF1_like-KH	122..237	CDD:239088	76/114 (67%)
Khdrbs3	NP_034288.2	Involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:O75525	1..160		87/158 (55%)
		Qua1	5..53	CDD:292891	18/50 (36%)
		SF1_like-KH	58..177	CDD:239088	80/121 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..266		10/53 (19%)
		Sam68-YY	266..320	CDD:293176	26/69 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..346		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845508
Domainoid	1	1.000	90	1.000	Domainoid score	I7744
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4780
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3911
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8696
orthoMCL	1	0.900	-	-		OOG6_110428
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760