DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qkr54B and Khdrbs1

DIOPT Version :9

Sequence 1:	NP_001261050.1	Gene:	qkr54B / 36966	FlyBaseID:	FBgn0022987	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_569089.1	Gene:	Khdrbs1 / 117268	RGDID:	621459	Length:	443	Species:	Rattus norvegicus

Alignment Length:	421	Identity:	143/421 - (33%)
Similarity:	197/421 - (46%)	Gaps:	102/421 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RKPGGSIGAPGGAHNGDASAHDHGHHGGDPGGNVQI------------------NEKANEYIRDC 72
            |..||..|..|||....|:.........:||.:..:                  .|..|:|:.:.
  Rat    43 RSRGGGGGPRGGARASPATQPPPLLPPSNPGPDATVVGSAPTPLLPPSATAAAKMEPENKYLPEL 107

  Fly    73 MAERNRMDRKFPIAEKLLEGEIEKVQTTGRIPSREQKYADIYREKPLRISQRVLVPIREHPKFNF 137
            |||::.:|..|..|.:||..||||:|........|:.|.|::..|.:::.:|||:|::::|||||
  Rat   108 MAEKDSLDPSFTHAMQLLSVEIEKIQKGESKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNF 172

  Fly   138 VGKLLGPKGNSLRRLQEETLCKMTVLGRNSMRDRVKEEELRSSKDPKYAHLNSDLHVEISTIAPP 202
            |||:|||:||:::||||||..|::|||:.||||:.||||||...||||||||.||||.|....||
  Rat   173 VGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPP 237

  Fly   203 AEAYARIAYAMAELRKYLIPDSNDIIRQEQLRELMDSTSLNDNDNAKSGYKKTSHMQGGNNVLGG 267
            .||||.:|:||.|::|:|:||..|.|.|||..||   :.||.......|        .|.:|.|.
  Rat   238 CEAYALMAHAMEEVKKFLVPDMMDDICQEQFLEL---SYLNGVPEPSRG--------RGVSVRGR 291

  Fly   268 GS------------INPIGG--VKNTPHHSYRSS--QPSSFSKNVLAPKQKVMSILEKARTA--- 313
            |:            :.|..|  |:.||   .|.|  :.::.::.|..|.....:...:||||
  Rat   292 GAAPPPPPVPRGRGVGPPRGALVRGTP---VRGSITRGATVTRGVPPPPTVRGAPTPRARTAGIQ 353

  Fly   314 --------MDETY-GRGYDDGLGYDPHQSYDSYSYGTHGHGPHGPPANILGGVGGISGGGGRGGH 369
                    ..||| ..||||...   .|||:.|.                             |:
  Rat   354 RIPLPPTPAPETYEDYGYDDSYA---EQSYEGYE-----------------------------GY 386

  Fly   370 YESSDYEPDYGRREYYQHSPG-----YSAGG 395
            |..|.     |..|||.:..|     |.|.|
  Rat   387 YSQSQ-----GESEYYDYGHGELQDSYEAYG 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr54B	NP_001261050.1	Qua1	68..117	CDD:292891	17/48 (35%)
qkr54B	NP_001261050.1	SF1_like-KH	122..237	CDD:239088	70/114 (61%)
Khdrbs1	NP_569089.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95		10/51 (20%)
		Involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:Q07666	100..260		83/159 (52%)
		Qua1	102..153	CDD:406639	17/50 (34%)
		KH-I	152..257	CDD:412160	63/104 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..317		8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..345		2/18 (11%)
		Interaction with HNRNPA1. /evidence=ECO:0000250\|UniProtKB:Q07666	351..443		22/99 (22%)
		Sam68-YY	366..415	CDD:406871	20/84 (24%)
		Interaction with ZBTB7A. /evidence=ECO:0000250\|UniProtKB:Q07666	400..420		4/13 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..443		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348935
Domainoid	1	1.000	90	1.000	Domainoid score	I7586
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8931
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1163
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.850