DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qkr54B and KHDRBS1

DIOPT Version :9

Sequence 1:	NP_001261050.1	Gene:	qkr54B / 36966	FlyBaseID:	FBgn0022987	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_006550.1	Gene:	KHDRBS1 / 10657	HGNCID:	18116	Length:	443	Species:	Homo sapiens

Alignment Length:	377	Identity:	135/377 - (35%)
Similarity:	190/377 - (50%)	Gaps:	74/377 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RKPGGSIGAPGGAH----------------NGDASAHDHGHHGG-------DPGGNVQIN-EKAN 66
            |..||..|:.|||.                ..||:.      ||       .|.....:. |..|
Human    43 RSRGGGGGSRGGARASPATQPPPLLPPSATGPDATV------GGPAPTPLLPPSATASVKMEPEN 101

  Fly    67 EYIRDCMAERNRMDRKFPIAEKLLEGEIEKVQTTGRIPSREQKYADIYREKPLRISQRVLVPIRE 131
            :|:.:.|||::.:|..|..|.:||..||||:|........|:.|.|::..|.:::.:|||:|:::
Human   102 KYLPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQ 166

  Fly   132 HPKFNFVGKLLGPKGNSLRRLQEETLCKMTVLGRNSMRDRVKEEELRSSKDPKYAHLNSDLHVEI 196
            :||||||||:|||:||:::||||||..|::|||:.||||:.||||||...||||||||.||||.|
Human   167 YPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFI 231

  Fly   197 STIAPPAEAYARIAYAMAELRKYLIPDSNDIIRQEQLRELMDSTSLNDNDNAKSGYKKTSHMQG- 260
            ....||.||||.:|:||.|::|:|:||..|.|.|||..||   :.||       |..:.|..:|
Human   232 EVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLEL---SYLN-------GVPEPSRGRGV 286

  Fly   261 ---GNN-------VLGGGSINPIGG--VKNTPHHSYRSSQPSSFSKNVLAPKQKVMSILEKARTA 313
               |..       |..|..:.|..|  |:.||... ..::.::.::.|..|.....:...:||||
Human   287 PVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRG-AITRGATVTRGVPPPPTVRGAPAPRARTA 350

  Fly   314 -----------MDETYGR-GYDDGLGYDPHQSYDSY--------SYGTHGHG 345
                       ..|||.. ||||......::.|:.|        .|..:|||
Human   351 GIQRIPLPPPPAPETYEEYGYDDTYAEQSYEGYEGYYSQSQGDSEYYDYGHG 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr54B	NP_001261050.1	Qua1	68..117	CDD:292891	17/48 (35%)
qkr54B	NP_001261050.1	SF1_like-KH	122..237	CDD:239088	70/114 (61%)
KHDRBS1	NP_006550.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		12/58 (21%)
		Involved in homodimerization. /evidence=ECO:0000305\|PubMed:26758068	100..260		83/159 (52%)
		Qua1	102..153	CDD:406639	17/50 (34%)
		KH-I_KHDRBS1	152..257	CDD:411896	63/104 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..316		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..346		2/18 (11%)
		Interaction with HNRNPA1. /evidence=ECO:0000269\|PubMed:17371836	351..443		13/52 (25%)
		Sam68-YY	366..415	CDD:406871	11/37 (30%)
		Interaction with ZBTB7A. /evidence=ECO:0000269\|PubMed:24514149	400..420		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155061
Domainoid	1	1.000	90	1.000	Domainoid score	I7770
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S2169
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8456
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.760