DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qkr54B and KHDRBS3

DIOPT Version :9

Sequence 1:	NP_001261050.1	Gene:	qkr54B / 36966	FlyBaseID:	FBgn0022987	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_006549.1	Gene:	KHDRBS3 / 10656	HGNCID:	18117	Length:	346	Species:	Homo sapiens

Alignment Length:	314	Identity:	139/314 - (44%)
Similarity:	184/314 - (58%)	Gaps:	45/314 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EYIRDCMAERNRMDRKFPIAEKLLEGEIEKVQT-TGRIPSREQKYADIYREKPLRISQRVLVPIR 130
            :|:.:.|||::.:|..|..|.:|:..||||.|. .|:   .|:||.|:...|.:::.|:||:|::
Human     4 KYLPELMAEKDSLDPSFTHALRLVNQEIEKFQKGEGK---DEEKYIDVVINKNMKLGQKVLIPVK 65

  Fly   131 EHPKFNFVGKLLGPKGNSLRRLQEETLCKMTVLGRNSMRDRVKEEELRSSKDPKYAHLNSDLHVE 195
            :.||||||||||||:||||:|||||||.||::||:.||||:.||||||.|.:.||.|||.||||.
Human    66 QFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVL 130

  Fly   196 ISTIAPPAEAYARIAYAMAELRKYLIPDSNDIIRQEQLRELMDSTSLN-DNDNAKSGY---KKTS 256
            |...|||||||||:.:|:.|::|:||||.||.|||.||:||   |.|| .::||....   |.|.
Human   131 IEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQEL---TYLNGGSENADVPVVRGKPTL 192

  Fly   257 HMQG--------GNNVLGGGSINPIGGV----KNTPHHSYRSSQPSSFSKNVLAPKQKVM---SI 306
            ..:|        |.   ||.:..|:|.|    ..||.....:..|.|..:.:|.|:.:.:   ..
Human   193 RTRGVPAPAITRGR---GGVTARPVGVVVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGY 254

  Fly   307 LEKARTAMDETYGR-GYDDGLG--YDPHQSYDSY--SYGT----------HGHG 345
            .........||||. .||||.|  || .||||||  ||.|          :|||
Human   255 RPPPPPPTQETYGEYDYDDGYGTAYD-EQSYDSYDNSYSTPAQSGADYYDYGHG 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr54B	NP_001261050.1	Qua1	68..117	CDD:292891	18/49 (37%)
qkr54B	NP_001261050.1	SF1_like-KH	122..237	CDD:239088	76/114 (67%)
KHDRBS3	NP_006549.1	Involved in homodimerization. /evidence=ECO:0000269\|PubMed:26758068	1..160		87/158 (55%)
		Qua1	4..53	CDD:406639	18/51 (35%)
		KH-I_KHDRBS3	48..160	CDD:411898	69/111 (62%)
		Interaction with SIAH1. /evidence=ECO:0000269\|PubMed:15163637	212..251		9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..267		11/53 (21%)
		Sam68-YY	266..320	CDD:406871	21/43 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155045
Domainoid	1	1.000	90	1.000	Domainoid score	I7770
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4780
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8456
orthoMCL	1	0.900	-	-		OOG6_110428
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.710