DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and LPXN

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001137467.1	Gene:	LPXN / 9404	HGNCID:	14061	Length:	391	Species:	Homo sapiens

Alignment Length:	345	Identity:	83/345 - (24%)
Similarity:	124/345 - (35%)	Gaps:	93/345 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 DQLLDEIDKVFADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASI 587
            |.||:|:::   .......:.|.|.|    ||..|      ||:..|....:.::.:.|...:.:
Human    10 DALLEELER---STLQDSDEYSNPAP----LPLDQ------HSRKETNLDETSEILSIQDNTSPL 61

  Fly   588 P-------GIEDMNMY-----------PSCAGMPEQFQQLRLHGDEASGKNSTR----------- 623
            |       .|:::|:|           ||......|..:|..|..|...|.:.|
Human    62 PAQLVYTTNIQELNVYSEAQEPKESPPPSKTSAAAQLDELMAHLTEMQAKVAVRADAGKKHLPDK 126

  Fly   624 --------TIL-------------------CADCNQPIAMGEVAVKADRAGKEI-----AWHPGC 656
                    ::|                   ||.|.:||           |||.|     :|||..
Human   127 QDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPI-----------AGKVIHALGQSWHPEH 180

  Fly   657 FKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCCY 721
            |.|..|:|.:....:|...|..:|..|.. :|..|||..|...|..|..||..: |:|.:||.|.
Human   181 FVCTHCKEEIGSSPFFERSGLAYCPNDYH-QLFSPRCAYCAAPILDKVLTAMNQ-TWHPEHFFCS 243

  Fly   722 QCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQGVAWGDVHWHASCFVCAGV 786
            .|.|....:.:  .||...|.|...:..:|:.:|..|...:  .:..::..|..||..||||.
Human   244 HCGEVFGAEGF--HEKDKKPYCRKDFLAMFSPKCGGCNRPV--LENYLSAMDTVWHPECFVCG-- 302

  Fly   787 QCSKPLIGGRFCVKENMPFC 806
            .|......|.|...:..|||
Human   303 DCFTSFSTGSFFELDGRPFC 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726	19/61 (31%)
		LIM2_Testin_like	691..748	CDD:188727	19/56 (34%)
		LIM	755..810	CDD:295319	15/52 (29%)
LPXN	NP_001137467.1	LIM1_Leupaxin	155..209	CDD:188790	20/64 (31%)
		LIM2_Leupaxin	216..267	CDD:188792	17/53 (32%)
		LIM3_Leupaxin	275..327	CDD:188794	15/52 (29%)
		LIM4_Paxillin_like	334..385	CDD:188725
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910