DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and LIMD1

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_055055.1	Gene:	LIMD1 / 8994	HGNCID:	6612	Length:	676	Species:	Homo sapiens

Alignment Length:	814	Identity:	165/814 - (20%)
Similarity:	247/814 - (30%)	Gaps:	260/814 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 DDDATGWAQFEILGQIRA-KPAYIKIKALASQPVQLEWVP--------------PNAAPDVVTDY 127
            |..|....:||...::.| |.|.|.::....|.:|.|.:|              |.|..:||...
Human    32 DKGAGNNPEFEETRRVFATKMAKIHLQQQQQQLLQEETLPRGSRGPVNGGGRLGPQARWEVVGSK 96

  Fly   128 MEKLGTAQIPVAGSDAALKRKMQLELQVPPH-----------------DLDAALCDGLTETEAIQ 175
            :...|.|:.|:|.|..|......|....||:                 ..|....:.|..:|...
Human    97 LTVDGAAKPPLAASTGAPGAVTTLAAGQPPYPPQEQRSRPYLHGTRHGSQDCGSRESLATSEMSA 161

  Fly   176 LQQYVQKLREQCVGQG--------VVVRLGDRLNHAQVEHVAPALMPTQEAQQTWQSLGL----- 227
            ..|........|:..|        ...:.||:          |.:.|         |:||
Human   162 FHQPGPCEDPSCLTHGDYYDNLSLASPKWGDK----------PGVSP---------SIGLSVGSG 207

  Fly   228 ---MPVADDTLNELLANPKVAQALASPASAHP--KLLVAFSEPLCESTAQFEENGALRAQTREKL 287
               .|.:|..|      ||       |...||  ...::.|.......:...:|..:..::.||.
Human   208 WPSSPGSDPPL------PK-------PCGDHPLNHRQLSLSSSRSSEGSLGGQNSGIGGRSSEKP 259

  Fly   288 LGISKPALLSLVTHGIVYDKVLGILQEKKLNISRD-PKLGPIAEFRKEYVNNPQFRAEINTICPQ 351
            .|:...|....|:.|:           ...|:... |.:||:
Human   260 TGLWSTASSQRVSPGL-----------PSPNLENGAPAVGPV----------------------- 290

  Fly   352 PPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDCGLPANTDYDRDP 416
            .|.||..|       :||.|..|   |.|...|.::.:.    |.||      |:.:..:.|..|
Human   291 QPRTPSVS-------APLALSCP---RQGGLPRSNSGLG----GEVS------GVMSKPNVDPQP 335

  Fly   417 VFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRGLNPATRAQLQSVGLDKNMLQS 481
            .|..                  .|.|.:.|:.|:.          :||        |||.:. |.
Human   336 WFQD------------------GPKSYLSSSAPSS----------SPA--------GLDGSQ-QG 363

  Fly   482 AVSN---APYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLLDEIDKVFADMANGCKDI 543
            ||..   .|       ...|.|....    |.|...||..:                       .
Human   364 AVPGLGPKP-------GCTDLGTGPK----LSPTSLVHPVM-----------------------S 394

  Fly   544 SYPKPSLGELPTSQSSDSGFHS----KPPTPGYGSEDLTAGQGRFASIPGIEDMNMYPSCAGMPE 604
            :.|:.|..|.|...|||....|    .|.:|          :.|....|.:....:.||.|.:..
Human   395 TLPELSCKEGPLGWSSDGSLGSVLLDSPSSP----------RVRLPCQPLVPGPELRPSAAELKL 449

  Fly   605 QFQQLRLHGDEASGKNSTRTILCADCNQPI--------AMGEVAVKADRAGKEIAWHPGCFKCIT 661
            :....||..:..:...:.....|..|::.:        |||.:            :|..||.|..
Human   450 EALTQRLEREMDAHPKADYFGACVKCSKGVFGAGQACQAMGNL------------YHDTCFTCAA 502

  Fly   662 CRELLADLVYFFHQGQVFCGRDL---AIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCCYQC 723
            |...|....::|..|:|||..|.   ..:....||..|..||......|..: ::|...|.|..|
Human   503 CSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGK-SYHPGCFRCVIC 566

  Fly   724 DEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQG-----VAWGDVHWHASCFVC 783
            :|.|.|..:..|.: |...|:..|.::.|.:|..|.:.|.|.:..     |...|..:|..|:.|
Human   567 NECLDGVPFTVDSE-NKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHC 630

  Fly   784 AGVQCSKPL---IGGRFCVKENMPFCSPTCVRSL 814
            .  .|...|   .|.|....|:..||....|:.|
Human   631 E--DCGLELNDEDGHRCYPLEDHLFCHSCHVKRL 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	22/125 (18%)
		LIM1_Testin_like	627..684	CDD:188726	16/64 (25%)
		LIM2_Testin_like	691..748	CDD:188727	16/56 (29%)
		LIM	755..810	CDD:295319	16/62 (26%)
LIMD1	NP_055055.1	Mediates nuclear export	54..134		18/79 (23%)
		Atrophin-1	<69..443	CDD:331285	96/540 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..163		10/58 (17%)
		Interaction with EGLN1/PHD2	186..260		19/105 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..389		62/333 (19%)
		Interaction with RB1. /evidence=ECO:0000269\|PubMed:15542589	404..442		9/47 (19%)
		Necessary for nuclear localization	472..676		53/207 (26%)
		LIM1_Ajuba_like	472..525	CDD:188738	16/64 (25%)
		LIM2_Ajuba_like	537..589	CDD:188741	15/53 (28%)
		LIM3_Ajuba_like	597..658	CDD:188822	16/62 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810