DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and SCEL

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_659001.2	Gene:	SCEL / 8796	HGNCID:	10573	Length:	688	Species:	Homo sapiens

Alignment Length:	709	Identity:	119/709 - (16%)
Similarity:	209/709 - (29%)	Gaps:	256/709 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 GQIRAKPAYIKIKALASQPVQLE---WVPP-----NAAPDVVTDYMEKLGTAQI------PVAGS 141
            |.:.|..:.......|:.||:.:   |.||     ||:....|...|......|      ||:..
Human   137 GSLNANTSNTIASTSATTPVKKKRQSWFPPPPPGYNASSSTGTRRREPGVHPPIPPKPSSPVSSP 201

  Fly   142 DAALKRKMQL---------------ELQVPPHDLDAALCDGLTETEAIQLQQYVQKLREQCVGQG 191
            :...:...|:               |..:...|||             .:.:....|:....|:.
Human   202 NQLRQDNRQIHPPKPGVYTETNRSAERNIRSQDLD-------------NIVKVATSLQRSDKGEE 253

  Fly   192 V--VVRLGDRLNHAQ----VEHVAPALMPTQEAQQTWQSLGLMPVADD-------------TLNE 237
            :  ::::...||..|    :....|.:...::..::.:||..|....|             .:|:
Human   254 LDNLIKMNKSLNRNQGLDSLFRANPKVEEREKRAKSLESLIYMSTRTDKDGKGIQSLGSPIKVNQ 318

  Fly   238 LL-ANPKVAQALASPASAHPKL--LVAFSEPLCESTAQFEENGALRAQTREKLLGISKPALLSLV 299
            .. .|.|..|.|.|.|..:.::  ....||.| ::..:....|......::.|.|:.|
Human   319 RTDKNEKGRQNLESVAKVNARMNKTSRRSEDL-DNATEVNPKGHENTTGKKDLDGLIK------- 375

  Fly   300 THGIVYDKVLGILQEKKLNISRDPKLGPIAEFRKEYVNNPQFRAEINTICPQPPMTPIKSPPGTP 364
                       :..|...||:|...|..:.:...|...:.|...::|......|.|...:..|..
Human   376 -----------VDPETNKNITRGQSLDNLIKVTPEVKRSNQGSKDLNNFIKVYPGTEKSTEGGQS 429

  Fly   365 FNSPL--------------PLKNPVQI--------RMGAQMRQDTPMRRVKFGGVSTIVYDCGLP 407
            .:|.:              .|:|.:::        ..|.....:...:.||
Human   430 LDSLIKVTPERNRTNQGNQDLENLIKVIPSANKSSEQGLDEHINVSPKAVK-------------- 480

  Fly   408 ANTDYDRDPVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRGLNPATRAQLQSV 472
             |||..:|  ..::::..|  ..|...:..:               .||.|..:|||.....||.
Human   481 -NTDGKQD--LDKLIKVNP--EIFTNNQRNQ---------------DLANLIKVNPAVIRNNQSQ 525

  Fly   473 GLDKNMLQ---SAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLLD---EIDK 531
            .|| |:::   ||:.|.                                  :.||.|:   |::.
Human   526 DLD-NLIKVKPSALRNT----------------------------------NRDQNLENLIEVNS 555

  Fly   532 VFADMANGCKDISYPKPSLGELPTSQSSDSGF-----------------HSKPPTPGYGSEDLTA 579
            ..::..||                  ||::|.                 :||.|..||..
Human   556 HVSENKNG------------------SSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQE----- 597

  Fly   580 GQGRFASIPGIEDMNMYPSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKAD 644
                  :|.|.....:|                  ..|.::.....:|..|.:|:.: |..:..|
Human   598 ------NISGKYIQTVY------------------STSDRSVIERDMCTYCRKPLGV-ETKMILD 637

  Fly   645 RAGKEIAWHPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTK 703
            ..  :|..|..||||..|::.|.:|.         .|..:.|..:...|..|...|..|
Human   638 EL--QICCHSTCFKCEICKQPLENLQ---------AGDSIWIYRQTIHCEPCYSKIMAK 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	18/117 (15%)
		LIM1_Testin_like	627..684	CDD:188726	15/56 (27%)
		LIM2_Testin_like	691..748	CDD:188727	4/13 (31%)
		LIM	755..810	CDD:295319
SCEL	NP_659001.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..231		17/93 (18%)
		16 X approximate tandem repeats	251..563		64/399 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..373		5/33 (15%)
		LIM	620..678	CDD:214528	17/69 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900