DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and ZYX

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001010972.1	Gene:	ZYX / 7791	HGNCID:	13200	Length:	572	Species:	Homo sapiens

Alignment Length:	492	Identity:	117/492 - (23%)
Similarity:	181/492 - (36%)	Gaps:	107/492 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 ICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDCGLPANTDY 412
            |.|.||..|  ...|.| .:|:|        ...|.|:......::...:|:::.|  :..|
Human   113 IFPSPPPPP--EEEGGP-EAPIP--------PPPQPREKVSSIDLEIDSLSSLLDD--MTKN--- 161

  Fly   413 DRDPVFAQILQ-------AEPL--KHAFQEARAGRAP--------SSVVISNIPAPVASLAELRG 460
              ||..|::..       |.|.  |.:.:.|..|.||        ||..:..:|||..|..:..
Human   162 --DPFKARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFH- 223

  Fly   461 LNPA----------TRAQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQV 515
            :.|.          .::|.|.|.|.....:...:::|.....|..:..|
Human   224 VQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVTPK---------------- 272

  Fly   516 HDWLLDDDQLLDEIDKVFADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGS--EDLT 578
                      ...:...|:..|.|... |.|...||. |.:.|:.:| ..:||:..|..  |...
Human   273 ----------FTPVASKFSPGAPGGSG-SQPNQKLGH-PEALSAGTG-SPQPPSFTYAQQREKPR 324

  Fly   579 AGQGRFASIPGIEDMNMYPSCAGMP-----------EQF-QQLRLHGDEASGKNSTRTILCADCN 631
            ..:.:....|..::.|...| .|.|           ||. |||....:....:|.....||..|:
Human   325 VQEKQHPVPPPAQNQNQVRS-PGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCH 388

  Fly   632 QPIAMGEVAVKADRAGKEIAWHPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRAC 696
            ||:|..:.||:|  .|:  .:|..||.|..|.:.|....::..:|..:|.......|:  :|..|
Human   389 QPLARAQPAVRA--LGQ--LFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE--KCNTC 447

  Fly   697 DELIFTKEYTAAEEATFHIKHFCCYQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVA 761
            .|.|..:...|..:| :|...|.|..|..||.|..:|.|: :|.|.|:..|.:.:|.||..|...
Human   448 GEPITDRMLRATGKA-YHPHCFTCVVCARPLEGTSFIVDQ-ANRPHCVPDYHKQYAPRCSVCSEP 510

  Fly   762 IGPADQG------VAWGDVHWHASCFVCAGVQCSKPL 792
            |.| :.|      |...|.::|..|:.|.  .|.|||
Human   511 IMP-EPGRDETVRVVALDKNFHMKCYKCE--DCGKPL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726	17/56 (30%)
		LIM2_Testin_like	691..748	CDD:188727	18/56 (32%)
		LIM	755..810	CDD:295319	14/44 (32%)
ZYX	NP_001010972.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..351		57/286 (20%)
		PAT1	<201..>365	CDD:330585	35/194 (18%)
		LIM1_Zyxin	351..437	CDD:188735	24/89 (27%)
		LIM	444..503	CDD:295319	20/60 (33%)
		LIM3_Zyxin	504..570	CDD:188819	14/44 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810